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Inflammatory Mediators

  • P. J. Barnes
  • K. F. Chung
  • C. P. Page
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 98)

Abstract

The pathological changes in asthma are likely to be produced by the release of several mediators from inflammatory cells in the airways and the purpose of this chapter is to review some of the inflammatory mediators which have been implicated. There is a vast and rapidly increasing literature dealing with these mediators and knowledge is advancing very rapidly, made possible by improved assays for mediators, by synthetic chemistry which provides pure forms of the mediators and, perhaps most importantly, by the development of potent and specific antagonists, so that the contribution of each mediator to asthma can be evaluated (Barnes et al. 1988a). We have emphasised, where possible, studies in human airways, since it is now increasingly apparent that inflammatory cells, the generation of mediators, and airway responses are markedly different between species, and it is difficult to extrapolate from animal experiments to human airway disease. Although various animal models share some of the features of asthma, there is no entirely satisfactory model. It is, therefore, important that more research should concentrate on human asthma, despite the difficulties involved in such studies.

Keywords

Airway Smooth Muscle Allergy Clin Immunol Human Airway Asthmatic Subject Bronchial Hyperresponsiveness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • P. J. Barnes
  • K. F. Chung
  • C. P. Page

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