Advertisement

Pathophysiology and Pharmacology of Aspirin-Induced Asthma

  • A. Szczeklik
  • C. Virchow
  • M. Schmitz-Schumann
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 98)

Abstract

Soon after its introduction into therapy in 1899, aspirin became an extremely successful analgesic and anti-inflammatory agent. Recently, its clinical applications have increased dramatically and include coronary artery disease and several related cardiovascular disorders. In patients with unstable angina or transient ischemic attacks aspirin favourably affects the course of disease, probably through its anti-platelet action (Reilly and Fitzgerald 1988). In acute myocardial infarction it significantly lowers mortality (isis-2 Collaborative Group 1988). Indeed, aspirin is now recognized as the most popular drug in the world.

Keywords

Allergy Clin Immunol Sodium Cromoglycate Sodium Salicylate Tiaprofenic Acid Aspirin Intolerance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ameisen JC, Capron A, Joseph M, Tonnel AB (1986) Platelets and aspirin induced asthma. In: Kay AB (ed) Clinical pharmacology and therapeutic progress in asthma. Blackwell, London, pp 226–236Google Scholar
  2. Anonymous (1989) Herpes simplex virus latency. Lancet 1: 194–195Google Scholar
  3. Arm JP, O’Hickey SP, Spur BW, Lee TW (1989) Airways responsivness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. Am Rev Respir Dis 140: 148–153PubMedGoogle Scholar
  4. Baldocchi G, Vervloet D, Charpin J (1983) Acetyl-salicylic acid therapy in aspirin-sensitive asthmatics. J Allergy Clin Immunol 71: 148–153Google Scholar
  5. Barles PG, Garcia FD, Olmo JRP, Aznar JP, Alarma JLE (1988) Adverse reaction to acetaminophen as an alternative analgesic in A AS triad. Allergol Immunopathol (Madr) 16: 321–325Google Scholar
  6. Basomba A, Romar A, Pelaez A, Villamanzo IG, Campos A (1976) The effect of sodium cromoglycate in preventing aspirin-induced bronchospasm. Clin Allergy 6: 269–275PubMedGoogle Scholar
  7. Bianco S (1986) Asthme et medicaments anti-inflammatories non-steroidiens. In: Charpin J (ed) Allergologie. Flammarion, Paris, p 683Google Scholar
  8. Bianco S, Robuschi M, Petrigni G (1977a) Aspirin-induced tolerance in aspirin- asthma detected by a new challenge technique. IRCS J Med Sci 5: 129–130Google Scholar
  9. Bianco S, Robuschi M, Petrigni G, Allegra L (1977b) Respiratory effects due to aspirin (ASA): ASA-induced tolerance in ASA-asthmatic patients. Bull Eur Physioplathol Respir 13: 123–124Google Scholar
  10. Bianco S, Petrigni C, Felisi R, Robuschi M (1979) Tolerance of guaiacolic ester of acetlsalicylic acid by patients with aspirin-induced asthma. Scand J Respir Dis 60: 350–354PubMedGoogle Scholar
  11. Bianco S, Robuschi M, Petrigni G (1982) Treatment of aspirin idiosyncrasy. J Allergy Clin Immunol 70: 222.Google Scholar
  12. Bisgaard H, Robinson C, Roemling F, Mygind N, Church M, Holgate S (1988) Leukotriene C4 and histamine in early allergic reactions in the nose. Allergy 43: 219–227PubMedGoogle Scholar
  13. Borgeat P, Fruteau de Laclos B, Maclouf J (1983) New concepts in the modulation of leukotriene synthesis. Biochem Pharmacol 32: 381–387PubMedGoogle Scholar
  14. Capron A, Ameisen JC, Joseph M, Auriault C, Tonnel AB, Caen J (1985) New function for platelets and their pathological implications. Int Arch Allergy Appl Immunol 77: 107–114PubMedGoogle Scholar
  15. Chiu JT (1983) Improvement in aspirin-sensitive asthmatic subjects after rapid aspirin desensitization and aspirin maintenance (ADAM) treatment. J Allergy Clin Immunol 71: 560–564PubMedGoogle Scholar
  16. Czerniawska-Mysik G, Szczeklik A (1981) Idiosyncrasy to pyrazolone drugs. Allergy 36: 381–384PubMedGoogle Scholar
  17. Dahl R (1981) Oral and inhaled sodium cromoglycate in challenge test with food allergens or acetylsalicylic acid. Allergy 36: 161–165PubMedGoogle Scholar
  18. Dajani BM, Sliman NA, Shubair KS, Hamzeh YS (1981) Bronchospasm caused by intravenous hydrocortisone sodium succinate ( Solu-Cortef) in aspirin-sensitive asthmatics. J All Clin Immunol 68: 201–205Google Scholar
  19. Delaney JC (1983) The effect of ketotifen on aspirin-induced asthmatic reactions. Clin Allergy 13: 247–251PubMedGoogle Scholar
  20. Di Rosa M, Flower RJ, Hirata F, Parente L, Russo-Marie F (1984) Anti-phospholipase proteins. Prostaglandins 28: 441–442PubMedGoogle Scholar
  21. Dor PJ, Vervloet D, Baldocchi G, Charpin J (1985) Aspirin intolerance and asthma induction of tolerance and long-term monitoring. Clin Allergy 15: 37–42PubMedGoogle Scholar
  22. Ellis M, Haydik I, Gillman S, Cummins L, Cairo M (1988) Immediate adverse reactions to acetaminophen. J Allergy Clin Immunol 81: 180 (abstract 348)Google Scholar
  23. Fabro L, Wuetrich B, Walti M (1987) Acetylsalicylic acid allergy and pyrazole allergy or pseudoallergy? Results of the skin tests and antibody determinations in a multicenter study. Z Hautkr 62: 470–478PubMedGoogle Scholar
  24. Farr RS (1970) The need to re-evaluate acetylsalicylic acid (aspirin). J Allergy 45: 321–326PubMedGoogle Scholar
  25. Ferreri NR, Howland WC, Stevenson DD, Spielberg HL, (1988) Release of leukotrienes, prostaglandins and histamine into nasal secretions of aspirin- sensitive asthmatics during reaction to aspirihn. Am Rev Respir Dis 137: 847–854PubMedGoogle Scholar
  26. Frick WE, Busse WW (1988) Respiratory infections: their role in airway responsiveness and pathogenesis of asthma. Clin Chest Med 9: 539–549PubMedGoogle Scholar
  27. Gerber JQ, Payne NA, Oelz O, Nies AS, Oates JA (1979) Tartrazine and the prostaglandin system. J Allergy Clin Immunol 63: 289–294PubMedGoogle Scholar
  28. Godard P, Chaintreuil J, Damon F, Coupe M, Flandre O, Crestes de Paulet A, Michel FB (1982) Functional assessment of alveolar macrophages: comparison of cells from asthmatic and normal subjects. J Allergy Clin Immunol 70: 88–93Google Scholar
  29. Goetzl EJ, Valacer DJ, Payan DG, Wong MYS (1986) Abnormal responses to aspirin of leukocyte oxygenation of arachidonic acid in adults with aspirin intolerance. J Allergy Clin Immunol 77: 693–698PubMedGoogle Scholar
  30. Goodwin JS (1985) Immunologic effects of nonsteroidal anti-inflammatory agents. Med Clin North Am 69: 793–804PubMedGoogle Scholar
  31. Gryglewski RJ (1989) Eicosanoids in aspirin-induced asthma. In: Schmitz-Schumann M, Menz G, Costabel U, Page CP (Eds) Intrinsic Asthma. Agents & Actions Suppl., Vol 28, pp 113–122Google Scholar
  32. Gryglewski RJ, Dembinska-Kiec A, Grodzinska L, Panczenko B (1976) Differential generation of substances with prostaglandin-like and thromboxane-like activities by guinea-pig trachea and lung strips. In: Bouhuyus A (ed) Lung cells in disease. Amsterdam, pp 209–307Google Scholar
  33. Gryglewski RJ, Szczeklik A, Nizankowska E (1977) Aspirin-sensitive asthma: its relationship to inhbition of prosaglandin biosynthesis. In: Berti F, Samuelson B, Velo GP (eds) Prostaglandins and thromboxanes. Plenum, New York, pp 191–203 ( NATO Advance Study Institute series A: Life science )Google Scholar
  34. Gryglewski RJ, Panczenko B, Korbut R, Grodzinska L, Ocetkiewicz A (1985) Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitised guinea-pig. Prostaglandins 10: 343–350Google Scholar
  35. Herberman RB (1986) Natural killer cells in lungs and other tissues and regulation of their activity by suppressor cells. J Allergy Clin Immunol 78: 566–570PubMedGoogle Scholar
  36. Higgs GA, Salmon JA, Henderson B, Vane JR (1987) Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proc Natl Acad Sci USA 84: 1417–1420PubMedGoogle Scholar
  37. Hollingsworth HM, Downin ET, Braman SS, Glassroth J, Binder R, Center DM (1984) Identiflcantin and characterization of neutrophil chemotactic acitivty in aspirin-induced asthma. Am Rev Respir Dis 130: 377–379Google Scholar
  38. ISIS-2 Collaborative Group (1988) Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 2: 154–176Google Scholar
  39. Jones DH, May AG, Condemi JJ (1984) HLA DR typing of aspirin-sensitive asthmathics. Ann Allergy 52: 87–89PubMedGoogle Scholar
  40. Joseph M, Capron A, Ameisen JC, Martinot JB, Tonnel AB (1987) Plaquettes sanguines et asthma a Faspirine. Allerg Immunol [Suppl] 19: 7–10Google Scholar
  41. King RA (1960) A severe anaphylactoid reaction to hydrocortisone. Lancet 2: 1093–1095Google Scholar
  42. Kounis NG (1976) Untoward reactions to corticosteroids: intolerance to hydorocortisone. Ann Allergy 36: 203–207PubMedGoogle Scholar
  43. Kowalski ML, Grzelewska-Rzymowska J, Rozniecki J, Szmidt M (1984) Aspirin tolerance induced in aspirin-sensitive asthmatics. Allergy 39: 171–178PubMedGoogle Scholar
  44. Kuehl FA, Dougherty HW, Ham EA (1984) Interactions between prostaglandins and leukotrienes. Biochem Pharmacol 33: 1–5PubMedGoogle Scholar
  45. Lands WEM (1981) Actions of anti-inflammatory drugs. Trends Pharmacol Sci, March: 78–80Google Scholar
  46. Lee TH, Drazen JM, Leitch AG, Ravalese J, Corey EJ, Robinson DR, Lewis RA, Austen KF (1986) Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis of guinea-pig pretreated by indomethacin or a fish-oil enriched diet. J Immunol 136: 2575–2582PubMedGoogle Scholar
  47. Lumry WR, Curd JG, Zeiger RS, Pleskow WW, Stevenson DD (1983) Aspirin- sensitive rhinosinusitis: the clinical syndrome and effects of aspirin administra¬tion. J Allergy Clin Immunol 71: 580–587PubMedGoogle Scholar
  48. Maclouf J, Fruteau de Laclos B, Borgeat P (1982) Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydro- peroxyeicosatetraenoic acid. Proc Natl Acad Sci USA 79: 6042–6046PubMedGoogle Scholar
  49. Martelli NA, Usandivaras G (1977) Inhibition of aspirin-induced bronchoconstriction by sodium cromoglycate inhalation. Thorax 32: 684–690PubMedGoogle Scholar
  50. Mendelson LM, Melzer EO, Hamburger RN (1974) Anaphylaxis-like reactions to corticosteroid therapy. J Allergy Clin Immunol 54: 125–129PubMedGoogle Scholar
  51. Morales MC, Basomba A, Pelaez A, Villalmanzo IG, Campos A (1985) Challenge tests with tartrazine in patients with asthma associated with intolerant to analgesics ( ASA-triad ). Clin Allergy 15: 55–59Google Scholar
  52. Morley J (1974) Prostaglandins and lymphokines in arthritis. Prostaglandins 8: 315–326PubMedGoogle Scholar
  53. Morley J, Sanjar C, Page CP (1984) Platelets in asthma. Lancet 2: 726–727Google Scholar
  54. Mullarkey MF, Thomas PS, Hansen JA, Webb DR, Nisperos B (1986) Association of aspirin-sensitive asthma with HLA-DQw2. Am Rev Respir Dis 133: 261–263PubMedGoogle Scholar
  55. Nizankowska E (1988) Aspirin-sensitive asthma and arachidonic acid metabolism. Doctor’s thesis. Copernicus Academy, CracowGoogle Scholar
  56. Nizankowska E, Szczeklik A (1979) Keine Bedenken gegen Solosin bei acetylsalicy-lsaure-emfindlichen Asthmatikern. Dtsch Med Wochenschr 104: 1388–1389PubMedGoogle Scholar
  57. Nizankowska E, Szczeklik A (1989) Glucocorticosteroids attenuate aspirin- precipitated adverse reactions in aspirin-intolerant patients with asthma. Ann Allergy 63: 159–162PubMedGoogle Scholar
  58. Nizankowska E, Sheridan AQ, Maile MH, Cross CJ, Czerniwska-Mysik G, Szczeklik A (1987) Pharmacological attempts to modulate leukotriene synthesis in aspirin-induced asthma. Agents Actions [Suppl] 21: 203–213Google Scholar
  59. Nizankowska E, Michalska Z, Wandzilak M, Radomski M, Marcinkiewicz E, Gryglewski R, Szczeklik A (1988) An abnormality of arachidonic acid metabolism is not a generalized phenomenon in patients with aspirin-induced asthma. Eicosanoids 1: 45–48PubMedGoogle Scholar
  60. Ortolani C, Mirone C, Fontana A, Folco GC, Miadonna A, Montalbetti N, Rinaldi M, Sala A, Tedeschi A, Valente D (1987) Study of mediators of anaphylaxis in nasal wash fluids after aspirin and sodium metabisulfite nasal provocation in intolerant rhinitic patients. Ann Allergy 59: 106–112PubMedGoogle Scholar
  61. Pagano JS (1988) Epstein-Barr virus. In: De Clerq E, Walker RT (eds) Anti-viral drug development. A multidiseiplinary approach. Plenum, New York, pp 81–90 (NATO Advance Study Institute series: Life science, Vol 143 )Google Scholar
  62. Partridge MR, Gibson GJ (1978) Adverse bronchial reactions to intravenous hydrocortisone in two aspirin-sensitive asthmatic patients. Br Med J 1: 1521PubMedGoogle Scholar
  63. Pash JM, Bailey M (1988) Inhibition by corticosteroids of epidermal growth factor-induced recovery of cyclooxygenase after aspirin inactivation. FASEB J 2: 2613–2618PubMedGoogle Scholar
  64. Picado C, Castillo JA, Schinca N, Pujades M, Ordinas A, Coronas A, Augusti-Vidal A (1988) Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. Thorax 43: 93–97PubMedGoogle Scholar
  65. Pleskow WW, Stevenson DD, Simon RA, Mathison DA, Schatz M, Zeiger RS (1983) Aspirin-sensitive rhino-sinusitis/asthma: spectrum of adverse reactions to aspirin. J Allergy Clin Immunol 71: 574–580PubMedGoogle Scholar
  66. Podgwaite JD, Mazzone HM (1986) Latency of insect virus. Adv Virus Res 31: 293–317PubMedGoogle Scholar
  67. Prieto L, Palop J, Castro J, Basomba A (1988) Aspirin-induced asthma in a patient with asthma previously improved by non-steroidal antiinflammatory drugs. Clin Allergy 18: 629–632PubMedGoogle Scholar
  68. Rainsford KD (1984) Aspirin and the salicylates. Butterworths, London Reilly IAG, Fitzgerald GA (1988) Aspirin in cardiovascular disease. Drugs 35: 154–176Google Scholar
  69. Roitt IM, Brostoff J, Male D (1985) Immunology. Churchill Livingstone, LondonGoogle Scholar
  70. Rosenkranz B, Fischer C, Messe CO, Froelich JC (1986) Effects of salicylic acid and acetylsalicylic acid alone and in combination on platelet aggregation and prostanoid synthesis in man. Br J Clin Pharmacol 21: 309–317Google Scholar
  71. Roth SH (1988) Salicylates revisited. Are they still the hall-mark of anti-inflammatory therapy? Drugs 31: 1–6Google Scholar
  72. Sagone AL Jr, Huseny RM (1987) Oxidation of salicylates by stimulated granulocytes: evidence that these drugs act as free radical scavengers in biological systems. J Immunol 138: 2177–2183PubMedGoogle Scholar
  73. Sakakibara H, Suetsugu S, Saga T, Handa M, Suzuki M, Doizoe T, Minako T, Horiguchi T, Konishi Y, Umeda H (1988a) Bronchial hyperresponsivness in aspirin-induced asthma. J Jpn Thorac Soc 26: 612–619Google Scholar
  74. Sakakibara H, Tsuda M, Suzuki M, Handa M, Saga T, Umeda H, Suetsugu SD, Konishi Y (1988b) A new method for diagnosis of aspirin-induced asthma by inhalation test with water soluble aspirin (aspirine-D, L -lysine, Venopirine). J Jpn Thorac 26: 275–283Google Scholar
  75. Samter M, Beers RF Jr (1968) Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Ann Intern Med 68: 975–983PubMedGoogle Scholar
  76. Samuellsson B (1983) Leucotrienes and mediators of immediate hypersensitivity reactions and inflammation. Science 220: 568–572Google Scholar
  77. Schlumberger HD (1980) Drug-induced pseudo-allergic syndrome as exemplified by acetylsalicylic acid intolerance. In: Dukor P, Kallos P, Schlumberger HD, West GB (eds) Pseudo-allergic reactions. Involvement of drugs and chemicals. Karger, Basel, pp 125–203Google Scholar
  78. Schmitz-Schumann M (1989) HLA-System and Analgetica-Asthma-Syndrom (AAS) Pneumologie 44: 580–581Google Scholar
  79. Schmitz-Schumann M, Schaub E, Virchow C (1982) Inhalative Provokation mit Lysin-Azetylsalicylsaeure bei Analgetika-Asthma-Syndrom. Prax Klin Pneumol 36: 17–21PubMedGoogle Scholar
  80. Schmitz-Schumann M, Juhl E, Costabel U, Ruehle K-H, Menz G, Virchow Chr, Mattys H (1985) Analgetikaprovokationsproben bei Analgetika-Asthma Syn¬drom. Atemwegs Lungenkrankh 11: 479–486Google Scholar
  81. Schmitz-Schumann M, Menz G, Schaufele A, von Feiten A, Matthys H, de Souze V, Virchow C (1987) Evidence of PAF release and platelet activation in anaglesics- syndrome. Agents Actions [Suppl] 21; 215–224Google Scholar
  82. Settipane GA (1981) Adverse reactions to aspirin and related drugs. Arch Intern Med 141: 328–332PubMedGoogle Scholar
  83. Settipane GA (1983) Aspirin and allergic diseases: a review. Am J Med 74: 102–109PubMedGoogle Scholar
  84. Settipane RA, Stevenson DD (1988) Cross-sensitivity with acetaminophen in ASA-sensitive asthmatics. J Allergy Clin Immunol 81: 180 (abstract 47)Google Scholar
  85. Shu Chan C, Brown IG, Oliver WA, Zimmerman PV (1984) Hydrocortisone-induced anaphylaxis. Med J Aust 141: 444–446Google Scholar
  86. Simon RA (1984) Adverse reactions to drug additives. J Allergy Clin Immunol 74: 623–630PubMedGoogle Scholar
  87. Simon RA, Pleskow WW, Stevenson DD, Mathison DA (1984) Aspirin sensitivity: description of aspirin (ASA) respiratory sensitivity. In: Kornblat J, Wedner C (eds) Allergy: theory and practice. Grune and Stratton, New York, pp 435–452Google Scholar
  88. Stevenson DD (1984) Diagnosis, prevention and treatment of adverse reactions to aspirin and nonsteroidal anti-inflammatory drugs. J Allergy Clin Immunol 74: 617–622PubMedGoogle Scholar
  89. Stevenson DD, Lewis RA (1987) Proposed mechanisms of aspirin sensitivity reactions. J Allergy Clin Immunol 80: 788–790PubMedGoogle Scholar
  90. Stevenson DD, Pleskow WW, Simon RA, Mathison DA, Lumry WR, Schatz M, Zeiger R (1984) Aspirin-sensitive rhinosinusitis asthma: a doule-blind cross-over study of treatment with aspirin. J Allergy Clin Immunol 73: 500–507PubMedGoogle Scholar
  91. Stevenson DD, Schrank PJ, Hougham AJ, Goldust MB, Wilson RR (1988) Salasate cross-sensitivity in aspirin-sensitive asthmatic. J Allergy Clin Immunol 81: 181Google Scholar
  92. Strieker BH, Meyboom RHB, Lindquist M (1985) Acute hypersensitivity reactions to paracetamol. Br Med J 291: 938–939Google Scholar
  93. Szczeklik A (1986) Analgesics, allergy and asthma. Drugs 32 [Suppl 4]: 148–163PubMedGoogle Scholar
  94. Szczeklik A (1988) Aspirin induced asthma as a viral disease. Clin Allergy 18: 15–20PubMedGoogle Scholar
  95. Szczeklik A (1990) Origin of aspirin-induced asthma. Agents Actions [Suppl] 28: 27–40Google Scholar
  96. Szczeklik A, Serwonska M (1979) Inhibition of idiosyncratic reactions to aspirin in asthmatic patients by clemastine. Thorax 34: 654–657PubMedGoogle Scholar
  97. Szczeklik A, Gryglewski RJ (1983) Asthma and antiinflammatory drugs. Mechanisms and clinical patterns. Drugs 25: 533–543Google Scholar
  98. Szczeklik A, Nizankowska E (1985) The effect of diflunisal on pulmonary function in aspirin-sensitive asthma. J Allergy Clin Immunol 75: 158 (abstract 216)Google Scholar
  99. Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G (1975) Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. Br Med J 1: 67–69PubMedGoogle Scholar
  100. Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G (1977a) Clinical patterns of hypersensitivity to nonsteroidal antiinflammatory drugs and their pathogenesis. J Allergy Clin Immunol 60: 276–284PubMedGoogle Scholar
  101. Szczeklik A, Nizankowska E, Nizankowski R (1977b) Bronchial reactivity to prostaglandins F2alpha, E2 and histamine in different types of asthma. Respiration 34: 323–331Google Scholar
  102. Szczeklik A, Czerniawska-Mysik G, Serwonska M, Kuklinski P (1980) Inhibition by ketotifen of idiosyncratic reactions to aspirin. Allergy 35: 421–424PubMedGoogle Scholar
  103. Szczeklik A, Nizankowska E, Czerniawska-Mysik G, Sek S (1985) Hydrocortisone and airflow impairement in aspirin-induced asthma. J Allergy Clin Immunol 76: 530–536PubMedGoogle Scholar
  104. Szczeklik A, Milner PC, Birch J, Watkins J, Martin JF (1986) Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. Thromb Haemost 56: 283–287PubMedGoogle Scholar
  105. Szczeklik A, Nizankowska E, Dworski R, Splawinski J, Gajewski P, Splawinska B (1987) Effects of inhibition of thromboxane A2 synthesis in aspirin-induced asthma. J Allergy Clin Immunol 80: 839–843PubMedGoogle Scholar
  106. Szczeklik A, Nizankowska E, Dworski R (1990) Choline magnesium trisalicylate in patients with aspirin induced asthma. Eur Resp of 3: 535–539.Google Scholar
  107. Taniguschi M, Sato A (1988) Aspirin-induced asthmatics (AIA) have cross-sensitivity with the steroid succinate esters. Abstr XIII Congress Allergy Clin Immunol, Montreux, abstract 358Google Scholar
  108. Toogood JH (1977) Aspirin intolerance, asthma, prostaglandins and cromolyn sodium. Chest 72: 35–37Google Scholar
  109. Tsuda M, Sakakibara H, Kamidaira T, Saga T, Suetsugu S, Umeda H (1988) Arachidonic acid metabolism of peripheral blood leukocytes in aspirin-induced asthma. Abstr XIII Congress Allergy Clin Immunol, Montreux, abstract 755Google Scholar
  110. Undem BJ, Pickett WC, Lichtenstein LM, Adams II GK (1987) The effect of indomethacin on imunologic release of histamine and sulfidopeptide leukotrienes from human bronchus and lung parenchuma. Am Rev Respir Dir 136: 1183–1187Google Scholar
  111. Vaghi A, Robuschi M, Simone P, Bianco S (1985) Bronchial response to leukotriene C4 (LTC4) in aspirin asthma. Abstracts SEP 4th Congress, Milano-Stresa, p 171Google Scholar
  112. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 231: 232–234Google Scholar
  113. Vane JR (1987) The evolution of non-steroidal anti-inflammatory drugs and their mechanism of action. Drugs 33 [Suppl 1]: 18–27PubMedGoogle Scholar
  114. Vargaftig BB (1978) Salicylic acid fails to inhibit generation of thromboxane A2 activity in platelets after in vivo administration to the rat. J Pharm Pharmacol 30: 101–104PubMedGoogle Scholar
  115. Vigano T, Toia A, Criveliari MT, Galli G, Mezzetti M, Folco GC (1988) Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. Eicosanoids 1: 73–77PubMedGoogle Scholar
  116. Virchow C (1976) Analgetika-Intoleranz bei Asthmatikern (Analgetika-Asthma- Sydrom); vorläufige Mitteilung. Prax Pneumol 30: 684–692PubMedGoogle Scholar
  117. Virchow C, Schmitz-Schumann M, Juhl-Schaub E (1986) Pyrazolones and analgesics-induced asthma syndrome. Agents Actions [Suppl] 19: 291–303Google Scholar
  118. Virchow C, Szczeklik A, Bianco S, Schmitz-Schumann M, Juhl E, Robuschi M, Damonte C, Menz G, Serwonska M (1988) Intolerance to tartrazine in aspirin-induced asthma: results of a multicenter study. Respiration 53: 20–23PubMedGoogle Scholar
  119. Voigtlaender V (1985) Dermatologische Nebenwirkungen von pyrazolonen. In: Brune K, Lanz R (eds) 100 Jahre Phyrazolone. Urban Schwarzenberg, Munich, pp 261–266Google Scholar
  120. Voigtlaender V, Haensch G, Rother U (1981) Acetylsalicylic acid intolerance: a possible role of complement. Int Arch Allergy Appl Immunol 66 [Suppl 1]: 154–155Google Scholar
  121. Weber RW, Hoffman M, Raine DA, Nelson HS (1979) Incidence of bronchoconstric- tion due to aspirin, azo dyes, non-azo dyes, and preservatives in a population of perennial asthmatics. J Allergy Clin Immunol 64: 32–37PubMedGoogle Scholar
  122. Welliver RC, Ogra PL (1988) Immunology of respiratory viral infections. Annu Rev Med 39: 147–162PubMedGoogle Scholar
  123. Wuetrich B, Fabro L (1981) Azetylsalicylsaeure and Lebensmittel additiva-Intoleranz bei Urtikaria, Asthma bronchiale und chronischer Rhinopathie. Schweiz Med Wochenschr 111: 1445–1449Google Scholar
  124. Yurchak AM, Wicher K, Arbesman CE (1970) Immunological studies on aspirin. Clinical studies with aspiryl-protein conjugates. J Allergy 46: 245–251Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • A. Szczeklik
  • C. Virchow
  • M. Schmitz-Schumann

There are no affiliations available

Personalised recommendations