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The Pathology of Asthma: An Overview

  • L. A. Laitinen
  • A. Laitinen
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 98)

Abstract

Classical dogma equates asthma with mucus plugs, bronchial smooth muscle hyperplasia, eosinophilia and thickening of the epithelial basement membrane. However, these characteristics are those seen at autopsy of lungs obtained from asthmatics who died from status asthmaticus and neither reflect the changes in early disease nor how they relate to disease severity (Houston et al. 1953; Cardell 1956; Dunnill et al. 1969; Thurlbeck et al. 1970). So far the fatal cases have contributed the most to our understanding of the pathological changes in asthma. In fact, until recent years it has been very uncommon to see biopsy material from asthmatics, and thus the histology of the airways of living stable asthmatics was unknown. The hallmark of asthma is the functional change associated with airways obstruction. At least in the early stages, bronchospasm is a function of smooth muscle tone, and it has been suggested that there may even not be any early morphological changes. Developments in bronchoscopic and electron microscopic techniques have been essential in obtaining knowledge of airway morphology in living asthmatics. In the future, along with the introduction of new techniques, special attention must be paid to careful patient characterization.

Keywords

Mast Cell Airway Smooth Muscle Airway Epithelium Ciliated Cell Bronchial Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ackerman SJ, Gleich GJ, Weller PF, Ottesen EA (1981) Eosinophilia And Elevated Serum Levels Of Eosinophil Major Basic Protein And Charcot-Leyden Crystal Protein (Lysophospholipase) After Treatment Of Patients With Bancroft’s Filariasis. J Immunol 127: 1093–1098PubMedGoogle Scholar
  2. Armour CL, Black JL, Berend N, Woolcock AJ (1984a) The Relationship Between Bronchial Hyperresponsiveness To Methacholine And Airway Smooth Muscle Structure And Reactivity. Respir Physiol 58: 223–233PubMedCrossRefGoogle Scholar
  3. Armour Cl, Lazar Nm, Schellenberg Rr, Taylor Sm, Chan N, Hogg Jc, Pare Pd (1984b) Comparison Of In Vivo And In Vitro Human Airway Reactivity To Histamine. Am Rev Respir Dis 129: 907–910PubMedGoogle Scholar
  4. Baier H, Long WM, Wanner A (1985) Bronchial Circulation In Asthma. Respiration 48: 199 - 205PubMedCrossRefGoogle Scholar
  5. Barnes PJ (1984) The Third Nervous System In The Lung: Physiology And Clinical Perspectives. Thorax 39: 561–567PubMedCrossRefGoogle Scholar
  6. Barnes PJ (1986a) Airway Inflammation And Autonomic Control. Eur J Respir Dis 69 [Suppl 147]: 80–87Google Scholar
  7. Barnes PJ (1986b) Asthma as An Axon Reflex. Lancet 1: 242–44PubMedCrossRefGoogle Scholar
  8. Beasley R, Roche WR, Roberts JA, Holgate ST (1989) Cellular Events In The Bronchi In Mild Asthma And After Bronchial Provocation. Am Rev Respir Dis 139: 806–817PubMedGoogle Scholar
  9. Boswell RN, Austen KF, Goetzl EJ (1978) Intermediate Molecular Weight Eosinophil Factor In Rat Peritoneal Mast Cells; Immunologic Release, Granule Association, And Demonstration Of Structural Heterogeneity. J Immunol 120: 15–20PubMedGoogle Scholar
  10. Boushey HA, Holtzman MJ (1985) Experimental Airway Inflammation And Hyper-Reactivity. Am Rev Respir Dis 13: 312–313Google Scholar
  11. Cardell BS (1956) Pathological Findings In Deaths From Asthma. Int Arch Allergy 9: 189PubMedCrossRefGoogle Scholar
  12. Charan NB, Turk G, Dhand R (1984) Gross And Subgross Anatomy Of Bronchial Circulation In Sheep. J Appl Physiol 57: 648–664Google Scholar
  13. Clark RAF, Dvorak HF, Colvin RB (1981) Fibronectin In Delayed-Type HypersenSitivity Skin Reactions. J Immunol 262: 497–500Google Scholar
  14. Cohen Rc, Prentice Aid (1959) Metaplastic Cells In Sputum Of Patients With PulMonary Eosinophilia. Tubercle 40: 44–46PubMedCrossRefGoogle Scholar
  15. Crystal Rg, Reynolds Hy, Kalica Ar (1986) Bronchoalveolar Lavage. The Report Of An International Congress. Chest 90: 122–128PubMedCrossRefGoogle Scholar
  16. Cudkowicz L (1979) Bronchial Arterial Circulation In Man: Normal Anatomy And Response To Disease. In: Moser Km (Ed) Lung Biology In Health And Disease, Vol 14: Pulmonary Vascular Diseases. Dekker, New York, Pp 111–232Google Scholar
  17. Cudkowicz L, Armstrong JB (1951) Observations On The Normal Anatomy Of The Bronchial Arteries. Thorax 6: 343–358PubMedCrossRefGoogle Scholar
  18. Curschmann H (1885) Einige Bemerkungen Über Die Im Bronchialsecret Vorkom¬Menden Spiralen. Dtsch Arch Klim Med 36: 578–585Google Scholar
  19. Cutz E, Levison H, Cooper DM (1978) Ultrastructure Of Airways In Children With Asthma. Histopathology 2: 407–421PubMedCrossRefGoogle Scholar
  20. Daly M de B, Hebb C (1966) Pulmonary And Bronchial Vascular Systems. Arnold, LondonGoogle Scholar
  21. Das RM, Jefferey PK, Widdicombe JG (1978) The Epithelial Innervation Of The Lower Respiratory Tract Of The Cat. J Anat 126: 123–131PubMedGoogle Scholar
  22. De Monchy JGR, Kauffman HF, Venge P Et Al. (1985) Bronchoalveolar Eosinophilia During Allergen-Induced Late Asthmatic Reactions. Am Rev Respir Dis 131: 373–377PubMedGoogle Scholar
  23. Deffebach ME, Charan N, Lakshminarayan F, Butler J (1987) The Bronchial Circulation; Small, But A Vital Attribute Of The Lung. Am Rev Respir Dis 135: 463–481PubMedGoogle Scholar
  24. Diaugustine RP, Sonstegard KS (1984) Neuroendocrine-Like (Small Granule) EpiThelial Cells Of The Lung. Environ Health Perspect 55: 271–295PubMedCrossRefGoogle Scholar
  25. Doidge JM, Satchell DG (1982) Adrenergic And Nonadrenergic Inhibitory Nerves In Mammalian Airways. J Auton Nerv Syst 5: 83–89PubMedCrossRefGoogle Scholar
  26. Dor PJ, Ackermann SJ, Gleich GJ (1984) Charcot-Leyden Crystal Protein And Eosinophil Granule Major Basic Protein In Sputum Of Patients With Respiratory Diseases. Am Rev Respir Dis 130: 1072–1077PubMedGoogle Scholar
  27. Dunnill Ma (1975) The Morphology Of The Airways In Bronchial Asthma. American College Of Chest Physicians, Park Ridge, Illinois, Pp 213–321Google Scholar
  28. Dunnill Ms (1960) The Pathology Of Asthma With Special To Changes In The Bronchial Mucosa. J Clin Pathol 13: 27–33PubMedCrossRefGoogle Scholar
  29. Dunnill Ms (1982) Pulmonary Pathology. Churchill Livingstone, EdinburghGoogle Scholar
  30. Dunnill Ms, Massarella Gr, Anderson Ja (1969) A Comparison Of The Quantitative Anatomy Of The Bronchi In Normal Subjects, In Status Asthmaticus, In Chronic Bronchitis, And In Emphysema. Thorax 24:176–Google Scholar
  31. Earle Bv (1953) Fatal Bronchial Asthma; Series Of 15 Cases With Review Of Literature. Thorax 8: 195–206CrossRefGoogle Scholar
  32. Empey Dw, Laitinen La, Jacobs L, Gold Wm, Nadel Ja (1976) Mechanism Of Bronchial Hyperreactivity In Normal Subjects After Upper Respiratory Tract InfecTions. Am Rev Respir Dis 113: 131–139PubMedGoogle Scholar
  33. Fabbri Lm, Boshetto P, Zocca E Et Al. (1987) Bronchoalveolar Neutrophilia During Late Asthmatic Reactions Induced By Toluene Di-Isocyanate. Am Rev Respir Dis 136: 36–42PubMedCrossRefGoogle Scholar
  34. Fillenz M, Woods RI (1970) Sensory Innervation Of The Airways. In: Porter R (Ed) Ciba Foundation Symposium: Breathing. Hering-Breuer Centenary Symposium. Churchill, London, Pp 101–107Google Scholar
  35. Filley WC, Holley KE, Kephart GM, Gleich GJ (1982) Identification By ImmunoFluorescence Of Eosinophil Granule Major Basic Protein In Lung Tissues Of Patients With Bronchial Asthma. Lancet 2: 11–15PubMedCrossRefGoogle Scholar
  36. Flint KC, Leung KBP, Hudspith BN Et Al. (1985) Bronchoalveolar Mast Cells In Extrinsic Asthma: A Mechanism For The Initiation Of Antigen Specific Broncho- Constriction. Br Med J 291: 923CrossRefGoogle Scholar
  37. Florange W (1960) Anatomie Und Pathologie Der Arteria Bronchialis. Ergeb Pathol Anat 39: 152–213Google Scholar
  38. Frigas E, Gleich GJ (1986) The Eosinophil And The Pathology Of Asthma. J Allergy Clin Immunol 77: 527–537PubMedCrossRefGoogle Scholar
  39. Frigas E, Loegering DA, Solley GO, Farrow GM, Gleich GJ (1981) Elevated Levels Of Eosinophil Granule Major Basic Protein In The Sputum Of Patients With BronChial Asthma. Proc Mayo Clin 56: 345–353PubMedGoogle Scholar
  40. Gaylor JB (1943) The Intrinsic Nervous Mechanism Of The Human Lung. Brain 57: 143–160CrossRefGoogle Scholar
  41. Glynn AA, Michaels L (1960) Bronchial Biopsy In Chronic Bronchitis And Asthma. Thorax 15: 142–153CrossRefGoogle Scholar
  42. Godard P, Chaintreuil J, Damon M Et Al. (1982) Functional Asessement Of Alveolar Macrophages: Comparison Of Cells From Asthmatics And Normal Subjects. J Allergy Clin Immunol 70: 88–94PubMedCrossRefGoogle Scholar
  43. Goetzl EJ, Austen KF (1975) Purification And Synthesis Of Eosinophilotactic Tetra- Peptides Of Human Lung Tissue: Identification As Eosinophil Chemotactic Factor Of Anaphylaxis. Proc Natl Acad Sei Usa 72: 4123–4127CrossRefGoogle Scholar
  44. Goetzl EJ, Phillips MJ, Gold WM (1983) Stimulus Specificity Of The Generation Of Leukotrienes By Dog Mastocytoma Cells. J Exp Med 158: 731–737PubMedCrossRefGoogle Scholar
  45. Grinnel F, Billingham RE, Burgess L (1981) Distribution Of Fibronectin During Wound Healing In Vivo. J Invest Dermatol 76: 181–189CrossRefGoogle Scholar
  46. Hayward J, Reid L (1952) Observations On The Anatomy Of The Intrasegmental Bronchial Tree. Thorax 7: 89–37PubMedCrossRefGoogle Scholar
  47. Heard BE, Hassain S (1973) Hyperplasia Of Bronchial Muscle In Asthma. J Pathol 110: 319–331CrossRefGoogle Scholar
  48. Heino M (1987) Morphological Changes Related To Ciliogenesis In The Bronchial Epithelium In Experimental Conditions And Clinical Course Of Disease. Eur J Respir Dis 151 [Suppl]:L-39Google Scholar
  49. Heino M, Mönkäre S, Haahtela T, Laitinen LA (1982) An Electronmicroscopic Study Of The Airways In Patients With Farmer’s Lung. Eur J Respir Dis 36: 52–61Google Scholar
  50. Heino M, Karjalainen J, Ylikoski J Et Al. (1988) Bronchial Ciliogenesis And Oral Steroid Treatment In Patients With Asthma. Br J Dis Chest 82: 175–178PubMedCrossRefGoogle Scholar
  51. Hers JFPH (1966) Disturbances Of The Ciliated Epithelium Due To Influenza Virus. Am Rev Respir Dis 93: 162–171PubMedGoogle Scholar
  52. Hinson JM, Hutchinson AA, Brigham KL, Meyrick BO, Snapper JR (1984) Effects Of Granulocyte Depletion On Pulmonary Responsiveness To Aerosol Histamine. J Appl Physiol 56: 411–417PubMedGoogle Scholar
  53. Holtzman MJ, Fabbri Lm, O’byrne Pm Et Al. (1983) Importance Of Airway InflammaTion For Hyperresponsiveness Induced By Ozone. Am Rev Respir Dis 127: 686–690PubMedGoogle Scholar
  54. Houston JC, Denavasquez S, Trouce JR (1953) A Clinical And Pathologic Study Of Fatal Cases Of Status Asthmaticus. Thorax 8: 207–213PubMedCrossRefGoogle Scholar
  55. Huber HL, Koessler KK (1922) The Pathology Of Bronchial Asthma. Arch Intern Med 30: 687–760CrossRefGoogle Scholar
  56. Hulbert VM, Melean T, Hogg JC (1985) The Effect Of Acute Airway Inflammation On Bronchial Reactivity In Guinea-Pigs. Am Rev Respir Dis 132: 7–11PubMedGoogle Scholar
  57. Hynes RO, Yamada KM (1982) Fibronectins: Multifunctional Modular Glycoproteins. J Cell Biol 95: 369–377PubMedCrossRefGoogle Scholar
  58. Keenan KP, Combs JW, Mcdowell EM (1982a) Regeneration Of Hamster Tracheal Epithelium After Mechanical Injury. I. Focal Lesions: Quantitative Morphologic Study Of Cell Proliferation. Virchows Arch [B] 41: 193–2CrossRefGoogle Scholar
  59. Keenan KP, Combs JW, Mcdowell EM (1982b) Regeneration Of Hamster Tracheal Epithelium After Mechanical Injury. Ii. Multifocal Lesions: Stathmokinetic And Autoradiographic Studies Of Cell Proliferation. Virchows Arch [B] 41: 215–229Google Scholar
  60. King As, Mclelland J, Cook Rd, King DZ, Walsh C (1974) The Ultrastructure Of Afferent Nerve Endings In The Avain Lung. Respir Physiol 22: 21–40PubMedCrossRefGoogle Scholar
  61. Laitinen A (1985) Ultrastructural Organization Of Intraepithelial Nerves In The Human Airway Tract. Thorax 40: 488–492PubMedCrossRefGoogle Scholar
  62. Laitinen A, Partanen M, Hervonen A, Laitinen La (1985a) Electron Microscopic Study Of The Innervation Of The Human Lower Respiratory Tract. Evidence Of Adrenergic Nerves. Eur J Respir Dis 67: 209–215PubMedGoogle Scholar
  63. Laitinen A, Partanen M, Hervonen A, Pelto-Huikko M, Laitinen LA (1985b) Vip-Like Immunoreactive Nerves In Human Respiratory Tract. Histochemistry 82: 313–319PubMedCrossRefGoogle Scholar
  64. Laitinen A, Laitinen LA, Moss R, Widdicombe JG (1989) Organization And Structure Of The Tracheal And Bronchial Blood Vessels In The Dog. J Anat 165: 133–140PubMedGoogle Scholar
  65. Laitinen LA (1974) Histamine And Methacholine Challenge In The Testing Of Bronchial Reactivity. Scand J Respir Dis 86 [Suppl]:L–48Google Scholar
  66. Laitinen LA (1988) Detailed Analysis Of Neural Elements In Human Airways. In: Kaliner M, Barnes P (Eds) Neural Regulation Of The Airways In Health And Disease. Dekker, New York Pp 35–36Google Scholar
  67. Laitinen LA (1989) Epithelial Damage. In: Hargreave Fe, Hogg JC, Malo J-L, Toogood JH (Eds) Glucocorticoids And Mechanisms Of Asthma. Excerpta Medica, Pp 215–229Google Scholar
  68. Laitinen LA, Laitinen A (1988) Mucosal Inflammation And Bronchial Hyperreactivity. Eur Respir J1 (5): 488–489Google Scholar
  69. Laitinen LA, Laitinen A (1990) Histology And Electron Microscopy. In: Butler J (Ed) The Bronchial Circulation (The Lung In Health And Disease-Series). Dekker, New York (In Press)Google Scholar
  70. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T (1985) Damage Of The Airway Epithelium And Bronchial Reactivity In Patients With Asthma. Am Rev Respir Dis 131: 599–606PubMedGoogle Scholar
  71. Laitinen La, Robinson Np, Laitinen A, Widdicombe Jg (1986) Relationship Between Mucosal Thickness And Vascular Resistance In Dogs. J Appl Physiol 61 (6): 2186–2193PubMedGoogle Scholar
  72. Laitinen LA, Laitinen A, Salonen Ro, Widdicombe JG (1987a) Vascular Actions Of Airway Neuropeptides. Am Rev Respir Dis 136: 59–64Google Scholar
  73. Laitinen LA, Laitinen A, Widdicombe JG (1987b) Effects Of Inflammatory And Other Mediators On Airway Vascular Beds. Am Rev Respir Dis 135 (6): 67–70Google Scholar
  74. Larsell G, Dow LS (1933) The Innervation Of The Human Lung. Am J Anat 52: 125–146CrossRefGoogle Scholar
  75. Lauweryns JM, Peuskens JC (1972) Neuro-Epithelial Bodies (Neuroreceptor Or Secretory Organs?) In Human Infant Bronchial And Bronchiolar Epithelium. Anat Rec 172: 471–482PubMedCrossRefGoogle Scholar
  76. Lauweryns JM, De Boc V, Guelinckx P, Decramer M (1983) Effects Of Unilateral Hypoxia On Neuroepithelial Bodies In Rabbit Lungs. J Appl Physiol 55: 1665–1668PubMedGoogle Scholar
  77. Lauweryns JM, Van Lommer AT, Dom RJ (1985) Innervation Of Rabbit Intrapul- Monary Neuroepithelial Bodies. Quantitative And Qualitative Ultrastructural Study After Vagotomy. J Neuro Sci 67: 81–92CrossRefGoogle Scholar
  78. Lee L-Y, Bleeker ER, Nadel J A (1977) Effect Of Ozone On Bronchomotor Response To Inhaled Histamine Aerosol In Dog. J Appl Physiol 43: 626–631PubMedGoogle Scholar
  79. Liebow A A (1960) The Bronchopulmonary Venous Collateral Circulation With Special To Emphysema. Am J Pathol 37: 361–380Google Scholar
  80. Lundberg JM, Sana A (1983) Capsaicin-Induced Desensitisation Of Airway Mucosa To Cigarette Smoke, Mechanical And Chemical Irritants. Nature 302: 251–253PubMedCrossRefGoogle Scholar
  81. Lundberg JM; Hokfelt T, Kewenter J, Pettersson G, Ahlman H, Edin R, Dahlstrom A, Nilsson G, Terenius L, Uvnas-Wallensten K, Said S (1979) Substance P-, Vip- And Enkephalin-Like Immunoreactivity In The Human Vagus Nerve. Gastroen-Terology 77: 469–471Google Scholar
  82. Lundgren R, Soderberg M, Horstedt, Stenling R (1988) Morphological Studies Of Bronchial Mucosal Biopsies From Asthmatics Before And After Ten Years Of Treatment With Inhaled Steroids. Eur Respir J 1: 883–889PubMedGoogle Scholar
  83. Mcdonald DM (1987) Neurogenic Inflammation In The Respiratory Tract: Actions Of Sensory Nerve Mediators On Blood Vessels And Epithelium Of The Airway Mucosa. Am Rev Respir Dis 136: 65–72Google Scholar
  84. Mcdonald DM (1988) Respiratory Tract Infections Increase Susceptibility To NeuroGenic Inflammation In The Rat Trachea. Am Rev Respir Dis 137: 1432–1440PubMedGoogle Scholar
  85. Mcdowell Em, Beals Tf (1987) Biopsy Pathology Of The Bronchi. Saunders, PhiLadelphiaGoogle Scholar
  86. Mcdowell EM, Becci PJ, Schiirch W, Trump FF (1979) The Respiratory Epithelium. Vii. Epidermoid Metaplasia Of Hamster Tracheal Epithelium During Regeneration Following Mechanical Injury. Jnci 62: 995–1008PubMedGoogle Scholar
  87. Mclaughlin RF Jr (1983) Bronchial Artery Distribution In Various Mammals And Humans. Am Rev Respir Dis 128:S 57–58Google Scholar
  88. Melen J, Pipkorn U (1985) Mast Cells On The Surface Of The Mucous Membrane A General Features In Inflammatory Reactions In The Nose? Rhinology 23: 187PubMedGoogle Scholar
  89. Miller SW (1947) The Lung, 2nd Edn. Thomas, SpringfieldGoogle Scholar
  90. Mullen JBM, Wiggs BR, Wright JL, Hogg JC, Pare PD (1986) Nonspecific Airway Reactivity In Cigarette Smokers. Am Rev Respir Dis 133: 120–125PubMedGoogle Scholar
  91. Murlas C, Roum JH (1985a) Bronchial Hyperreactivity Occurs In Steroid Treated Guineapigs Depleted Of Leukocytes By Cyclophosphamide. J Appl Physiol 58: 1630–1637PubMedGoogle Scholar
  92. Murlas C, Roum JH (1985b) Sequence Of Pathological Change In The Airway Mucosa Of Guinea-Pigs During Ozone Induced Bronchial Hyperreactivity. Am Rev Respir Dis 131: 314–320PubMedGoogle Scholar
  93. Nadel J (1984) Inflammation And Asthma. J Allergy Clin Immunol 73: 651–653PubMedCrossRefGoogle Scholar
  94. Nadel JA, Barnes PJ (1984) Autonomic Regulation Of The Airways. Annu Rev Med 35: 451 - 467PubMedCrossRefGoogle Scholar
  95. Naylor B (1962) The Shedding Of The Mucosa Of The Bronchial Tree In Asthma. Thorax 17: 69–72PubMedCrossRefGoogle Scholar
  96. Oertel HL, Kaliner MA (1981) The Biological Activity Of Mast Cell Granules. Iii. Purification Of Inflammatory Factors Of Anaphylaxis (If-A) Responsible For Causing Late-Phase Reactions. J Immunol 112: 1398–1402Google Scholar
  97. Partanen M, Laitinen A, Hervonen A, Toivanen M, Laitinen LA (1982) CatecholaMine- And Acetylcholinesterase-Containing Nerves In Human Lower Respiratory Tract. Histochemistry 76: 175–188PubMedCrossRefGoogle Scholar
  98. Persson CG A (1986) Role Of Plasma Exudation In Asthmatic Airways. Lancet 2: 1126–1128PubMedCrossRefGoogle Scholar
  99. Persson CGA (1988) Plasma Exudation And Asthma. Lung 166: 1–23PubMedCrossRefGoogle Scholar
  100. Phillips MJ, Calonico L, Gold WM (1982) Morphological And Pharmacological Characterization Of Dog Mastocytoma Cells. Am Rev Respir Dis 125: 63aGoogle Scholar
  101. Pietra GG, Magno M (1978) Pharmacologic Factors Influencing Permeability Of The Bronchial Microcirculation. Fed Proc 37: 2466–2470PubMedGoogle Scholar
  102. Pietra GG, Szidon JP, Leventhal MM, Fisherman AP (1971) Histamine And InterStitial Pulmonary Edema In The Dog. Circ Res 29: 323–337PubMedGoogle Scholar
  103. Reid L (1974) Histological Aspects Of Bronchial Secretion. Experimental Studies On Bronchial Secretion And Therapeutical Aspects Of Pathological Bronchial Secretion. Scand J Respir Dis 90 [Suppl]: 9–15Google Scholar
  104. Reid L, Jones R (1979) Bronchial Mucosal Cells. Fed Proc 38: 191–196PubMedGoogle Scholar
  105. Rhodin JAG (1974) Respiratory System. In: Histology. Oxford University Press, New York, Pp 607–645Google Scholar
  106. Richardson JB (1979) Nerve Supply To The Lungs. Am Rev Respir Dis 119: 785–802PubMedGoogle Scholar
  107. Richardson JB, Beland J (1976) Non-Adrenergic Inhibitory Nervous System In Human Airways. J Appl Physiol 41: 764–771PubMedGoogle Scholar
  108. Said Si, Kitamura S, Yoshida T, Preskitt J, Holden LD (1974) Humoral Control Of Airways. Ann Ny Acad Sei 221: 103–114CrossRefGoogle Scholar
  109. Saksela O, Alitalo K, Kiistala U, Vaheri A (1981) Basal Lamina Components In Experimentally Induced Skin Blisters. J Invest Dermatol 77: 283–286PubMedCrossRefGoogle Scholar
  110. Salvato G (1986) Asthma And Mast Cells Of Bronchial Connective Tissue. Experientia 18: 330–331CrossRefGoogle Scholar
  111. Sanerkin NG, Evans DMD (1965) The Sputum In Bronchial Asthma: Pathognomic Patterns. J Pathol 89: 535–541CrossRefGoogle Scholar
  112. Schatz M, Wasserman S, Patterson R (1981) Eosinophils And Immunologic Lung Disease. Symposium On Clinical Allergy. Med Clin North Am 65: 1055–1071PubMedGoogle Scholar
  113. Sobonoya RE (1984) Concise Clinical Study: Quantitative Structural Alterations In Long Standing Allergic Asthma. Am Rev Respir Dis 130: 289Google Scholar
  114. Solley GO, Gleich GJ, Jordan Scroeter AL (1976) Late Phase Of The Immediate Wheal And Flare Skin Reaction: Its Dependence on Ige Antibodies. J Clin Invest 58: 408–420PubMedCrossRefGoogle Scholar
  115. Spencer H, Leof D (1964) The Innervation Of The Human Lung. J Anat 98: 599–609PubMedGoogle Scholar
  116. Suslov KI (1895) Some Investigations On The Anatomy of The Bronchial Arteries In Man (In Russian) Thesis,Google Scholar
  117. St Petersburgh Takizawa T, Thurlbeck WM (1971) Muscle And Mucous Gland Size In The Major Bronchi Of Patients With Chronic Bronchitis, Asthma And Asthmatic Bronchitis. Am Rev Respir Dis 104: 331–336PubMedGoogle Scholar
  118. Tannenbaum S, Oertel H, Henderson WR, Kaliner M (1980) The Biologic Activity Of Mast Cell Granules. I. Elicitation Of Inflammatory Responses In Rat Skin. J Immunol 125: 325–335PubMedGoogle Scholar
  119. Thurlbeck WM, Henderson JA, Fräser RG, Bates DV (1970) Chronic Obstructive Lung Disease. A Comparison Between Clinical, Roentgenologic, Functional And Morphologic Criteria In Chronic Bronchitis, Emphysema, Asthma And BronchiEctasis. Med 49: 81–147Google Scholar
  120. Tomioka M, Ida S, Shondoh Y Et Al. (1984) Mast Cells In Bronchoalveolar Lumen Of Patients With Bronchial Asthma. Am Rev Respir Dis 129: 1000–1005PubMedGoogle Scholar
  121. Turnbull LS, Turnbull LW, Crofton LW, Kay AB (1978) Immunoglobulins, ComPlement And Arylsulphatase In Sputum From Chronic Bronchitis And Other Pulmonary Diseases. Clin Exp Immunol 32: 226–232PubMedGoogle Scholar
  122. Vaheri A, Salonen E-M, Vartio T, Hedman K, Stenman S (1983) Fibronectin And Tissue Injury. In: Woolf N (Ed) Biology And Pathology Of The Vessel Wall. Praeger, Eastbourne, P 161Google Scholar
  123. Vaheri A, Salonen EM, Vartio T (1985) Fibronectin In Formation And Degradation Of The Pericellular Matrix. In: Evered D, Whelan J (Eds) Fibrosis, Ciba Foundation Symposium. Pitman, London, P 111Google Scholar
  124. Wardlaw AJ, Dunnette S, Gleich GJ Et Al. (1988) Eosinophils And Mast Cells In Bronchoalveolar Lavage In Subjects With Mild Asthma. Am Rev Respir Dis 137: 62PubMedCrossRefGoogle Scholar
  125. Weller PF, Lee CW, Foster DW, Corey EJ, Austen KF, Lewis RA (1983) Generation And Metabolism Of 5-Lipoxygenase Pathway Leukotrienes By Human Eosinophils: Predominant Production Of Leukotriene C4. Proc Natl Acad Sci Usa 80: 7626–7630PubMedCrossRefGoogle Scholar
  126. Wenzel SE, Fowler AA, Schwartz LB (1988) Activation Of Pulmonary Mast Cells By Bronchoalveolar Allergen Challenge. Am Rev Respir Dis 137: 1002–1008PubMedGoogle Scholar
  127. Widdicombe JG (1985) Control of Airway Caliber. Am Rev Respir Dis 131 [Suppl]: 33 - 35Google Scholar
  128. Wilhelm DL (1953) Regeneration of Tracheal Epithelium. J Pathos Bat 65: 543–550CrossRefGoogle Scholar
  129. Yamada KM, Olden K (1978) Fibronectin-Adhesive Glycoproteins Of Cell Surface And Blood. Nature 275: 179–184PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1991

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  • L. A. Laitinen
  • A. Laitinen

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