Radioimmunoconjugates in Renal Cell Carcinoma
The long-awaited clinical benefits of radioimmunoscintigraphy (RIS) and radioimmunotherapy (RIT) are being realized in a slow but steadily progressive fashion . The visualization of tumor foci no longer requires extensive manipulative steps to discriminate uptake of radiolabeled antibody by the tumor from that of the blood pool or normal tissues, and in therapeutic regimens significant tumor responses are becoming more common. However, the past decade of animal studies and clinical efforts utilizing radionuclide conjugated monoclonal antibodies (MAb) has demonstrated the vast complexities of the task at hand, and even as enthusiasm is growing, significant hurdles remain to be cleared if RIS and RIT are to achieve their anticipated clinical potential. We have been actively exploring the use of RIS and RIT in renal cell carcinoma (RCC) xenografts for 5 years and in clinical trials for approximately 2 years. This report will briefly review the progress to date and then in more detail will provide an overview of the key RIS and RIT issues that are being addressed by the scientific community.
KeywordsRenal Cell Carcinoma Human Renal Cell Carcinoma Mass Dose Human Anti Mouse Antibody Human Renal Cell Cancer
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