Active Specific Immunotherapy in Renal Cell Carcinoma: Optimization

  • C. S. McCune
Conference paper


The requirements for effective cancer vaccines have gradually been worked out in experimental models over the past 15 years [1–3]. Many clinical trials in this field were initiated before this information was available or did not adhere to the methodologic requirements that had been found in the animal studies. As a consequence, there are several negative clinical investigations of active specific immunotherapy in which failure was a virtual certainty [4–6] when looked at in retrospect with regard to the requirements that have been identified in animal models. Some of the key requirements are as follows.


Renal Cell Carcinoma Renal Carcinoma Antigenic Diversity Autologous Tumor Cell Active Specific Immunotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • C. S. McCune
    • 1
  1. 1.Medical Oncology DivisionUniversity of Rochester Medical CenterRochesterUSA

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