Combination Therapy with Interferon in Renal Cell Carcinoma

  • S. D. Fossa
Conference paper


Interferon alpha (IFNα) yields a 15%–20% response rate in patients with metastatic renal cell carcinoma (RCC) when given as monotherapy at doses of 9–18 x 106 U thrice weekly [22]. There seems to be no significant difference in the response rates obtained by different IFNs: IFNα, EFNβ, natural leukocyte IFN, of recombinant IFN. Monotherapy with IFNγ has, however, been insufficiently evaluated in clinical studies. Due to the considerable interstudy variability of the selection criteria of patients treated with IFN, the overall role of this drug in the management of metastatic RCC cannot yet be determined. However, IFN therapy of RCC represents the first treatment of this malignancy which has consistently achieved a response rate of 10% or more. The most frequently responding sites are lung metastases [27]. Treatment should be given for at least 2 months unless the patient progresses before this time interval has elapsed. Patients who after 2 months show an at least 30% reduction have a reasonable chance of finally obtaining an objective response [15]. Responders usually live longer than nonresponders [4, 15], which, however, may mirror a biologically less aggressive disease rather than treatment efficacy.


Renal Cell Carcinoma Renal Cell Cancer Metastatic Renal Cell Carcinoma Advanced Renal Cell Carcinoma Cytostatic Drug 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • S. D. Fossa
    • 1
  1. 1.The Norwegian Radium HospitalOslo 3Norway

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