Functional and Pathophysiological Considerations

  • Peter Henricus Maria Franciscus van Domburg
  • Hendrik Jan ten Donkelaar
Part of the Advances in Anatomy Embryology and Cell Biology book series (ADVSANAT, volume 121)


Although it has been known for many years that various disturbances of movement and posture are associated with lesions in one or another of the basal ganglia (e.g., Wilson 1914; Denny-Brown 1960, 1962; Denny-Brown and Yanagisawa 1976; DeLong and Georgopoulos 1981), it is still not possible to account for individual symptoms, such as tremor, rigidity, or athetosis, in terms of normal or abnormal functioning of a particular component of the basal ganglia. Tremor cannot be produced in animals by lesions limited to structures of the basal ganglia. Neither electrolytic lesions of the SN nor 6-hydroxydopamine (6-OHDA) lesions of the ascending DAergic pathways from the SN and adjacent VTA produced tremor (Poirier 1960; DeLong and Georgopoulos 1981). It is only when lesions of the ascending cerebellar efferents are combined with nigrostriatal lesions that tremor appears. The usual site at which lesions are placed is in the VTA of the midbrain. Here, the lesions interrupt several pathways involving the SN and red nucleus: nigrostriatal, cerebellorubral, cerebellothalamic, and rubroolivary tracts. The conclusion is that parkinsonian rest tremor is not due to a purely striatal DA deficiency, but that damage to other structures, particularly the cerebellorubrothalamic projections, must also be involved. The ventrolateral thalamic nucleus has long been known to be involved in tremor generation (see I.S. Cooper et al. 1968). Hypokinesia and rigidity, cardinal features in Parkinson’s disease, are hypothesized to result from a complex series of changes resulting in an increase in basal ganglia output, particularly to the ventrolateral thalamic nucleus (DeLong and Georgopoulos 1981; Albin et al. 1989).


Basal Ganglion Caudate Nucleus Superior Colliculus DAergic Neuron Neurofibrillary Degeneration 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Peter Henricus Maria Franciscus van Domburg
    • 1
  • Hendrik Jan ten Donkelaar
    • 2
  1. 1.Departments of Anatomy/Embryology and Neurology Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Department of Anatomy and Embryology Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands

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