Measurement of Histamine Metabolites

  • J. P. Green
  • G. D. Prell
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 97)


Affirming the usefulness of measuring the metabolites is not to deny the usefulness of measuring histamine itself. Its measurement alone has yielded a wealth of information on its role in, and contribution to, syndromes, diseases, and reactions to chemicals (see Neugebauer et al. 1987). In fact, measurement of a biogenic amine may sometimes be more revealing than measuring its metabolite(s). For example, the levels of 5-hydroxytryptamine (5-HT) were elevated in the CSF of patients with endogenous depression, but levels of its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA), were normal (Gjerris et al. 1987). Treatment of rats with an inhibitor of monoamine oxdiase raised levels of 5-HT in cisternal CSF without influencing the levels of 5-HIAA (Anderson et al. 1987). Treatment with a drug that releases 5-HT produced a 16-fold increase in the levels of 5-HT in the CSF with a less than twofold increase in 5-HIAA (Anderson et al. 1987).


Biogenic Amine Endogenous Substance Diamine Oxidase Monoamine Oxidase Activity Endogenous Depression 
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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • J. P. Green
  • G. D. Prell

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