Abstract
Affirming the usefulness of measuring the metabolites is not to deny the usefulness of measuring histamine itself. Its measurement alone has yielded a wealth of information on its role in, and contribution to, syndromes, diseases, and reactions to chemicals (see Neugebauer et al. 1987). In fact, measurement of a biogenic amine may sometimes be more revealing than measuring its metabolite(s). For example, the levels of 5-hydroxytryptamine (5-HT) were elevated in the CSF of patients with endogenous depression, but levels of its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA), were normal (Gjerris et al. 1987). Treatment of rats with an inhibitor of monoamine oxdiase raised levels of 5-HT in cisternal CSF without influencing the levels of 5-HIAA (Anderson et al. 1987). Treatment with a drug that releases 5-HT produced a 16-fold increase in the levels of 5-HT in the CSF with a less than twofold increase in 5-HIAA (Anderson et al. 1987).
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© 1991 Springer-Verlag Berlin Heidelberg
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Green, J.P., Prell, G.D. (1991). Measurement of Histamine Metabolites. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_9
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DOI: https://doi.org/10.1007/978-3-642-75840-9_9
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