Abstract
The histamine molecule is a substituted imidazole compound. These compounds are known to have poor gas chromatographic characteristics. Adsorption to glass surfaces of gas chromatographic columns and injection ports results in peak tailing and memory effects. Attaching a functional group to the imidazole ring can overcome these adsorption effects. In 1979 Mita et al. described a derivatization of histamine by which the side chain nitrogen was converted to a heptafluorobutyryl derivative and the secondary nitrogen in the imidazole ring to an ethoxycarbonyl derivative. Using this derivative the first descriptions of a gas chromatographic-mass spectrometric (GC-MS) method for the quantitative determination of histamine were published (Mita et al. 1980a,b). Soon after, the introduction of fused silica capillary gas chromatographic columns, chemical ionization techniques and more sophisticated mass spectrometers considerably enhanced the specificity and sensitivity of GC-MS determination of histamine (Keyzer et al. 1983, 1984a). Using positive ion chemical ionization mass fragmentography after separation on fused silica capillary columns, histamine extracted from biological fluids can be assayed down to 100 fmol/sample.
Keywords
- Histamine Concentration
- Histamine Dihydrochloride
- Side Chain Nitrogen
- Heptafluorobutyric Anhydride
- Urinary Histamine
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1991 Springer-Verlag Berlin Heidelberg
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Keyzer, J.J., Oosting, E. (1991). Determination in Biological Samples by Gas Chromatography-Mass Spectrometry. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_7
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DOI: https://doi.org/10.1007/978-3-642-75840-9_7
Publisher Name: Springer, Berlin, Heidelberg
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