Abstract
The brain is one of the last organs in which histamine receptors have been identified. This is not surprising in view of the slow emergence of the idea that the amine has an important role in neurotransmission in the CNS.
Keywords
- Histamine Receptor
- Cerebral Cortical Slice
- Hrreceptor Antagonist
- Inositol Phospholipid Hydrolysis
- Histamine Research
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Abel JJ, Kubota S (1919) Presence of histamine (4-imidazoleethylamine) in the hypophysis cerebri and other tissues of the body and its occurrence among the hydrolytic decomposition products of proteins. J Pharmacol 13:243
Aceves J, Mariscal S, Morrison KE, Young JM (1985) The binding of doxepin to histamine Hj receptors in guinea pig and rat brain. Br J Pharmacol 84:417–424
Ahn HS, Barnett A (1986) Selective displacement of [3H]-mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur J Pharmacol 127:153–155
Airaksinen MS, Panula P (1988) The histaminergic system in the guinea-pig central nervous system: an immunocytochemical mapping using an antiserum against histamine. J Comp Neurol 273:163–186
Al-Gadi M, Hill SJ (1985) Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices. Br J Pharmacol 85:877–888
Armstrong WE, Sladek CD (1985) Evidence for excitatory actions of histamine on supraoptic neurons in vitro: mediation by an Hrtype receptor. Neuroscience 16:307–322
Arrang JM, Garbarg M, Schwartz JC (1983) Autoinhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature 302:832–837
Arrang JM, Garbarg M, Quach TT, Dam Trung Tuong M, Yeramian E, Schwartz JC (1985a) Actions of betahistine at histamine receptors in the brain. Eur J Pharmacol 111:73–84
Arrang JM, Garbarg M, Schwartz JC, (1985b) Histamine synthesis and release in CNS: control by autoreceptors (H3). In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 143–153
Arrang JM, Garbarg M, Schwartz JC (1985c) Autoregulation of histamine release in brain by presynaptic H3-receptors. Neuroscience 15:553–562
Arrang JM, Schwartz JC, Schunack W (1985d) Stereoselectivity of the histamine H3-presynaptic autoreceptor. Eur J Pharmacol. 117:109–114
Arrang JM, Garbarg M, Lancelot JC, Lecomte JM, Pollard H, Robba M, Schunack W, Schwartz JC (1987a) Highly potent and selective ligands for histamine H3-receptors. Nature 327:117–123
Arrang JM, Garbarg M, Schwartz JC (1987b)Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors. Neuroscience 23:149–157
Arrang JM, Defontaine N, Schwartz JC (1988a) Phencyclidine blocks histamine H3-receptors in rat brain. Eur J Pharmacol 157:31–35
Arrang JM, Devaux B, Chodkiewicz JP, Schwartz JC (1988b) H3-receptors control histamine release in human brain. J Neurochem 51:105–108
Arrang JM, Roy J, Morgat JL, Schunack W, Schwartz JC (1990) Histamine H3-receptor binding sites in rat brain membranes: modulations by guanine nucleotides and divalent cations. Eur J Pharmacol Mol Pharmacol Sect. 188: 219–227
Atack C, Carlsson A (1972) In vitro release of endogenous histamine, together with noradrenaline and 5-hydroxytryptamine, from slices of mouse cerebral hemispheres. J Pharm Pharmacol 24:990–992
Autio V, Ermala P (1949) Determination of histamine in cerebrospinal fluid in some neuropsychiatric cases. Ann Med Exp Biol Fenn 27:87–91
Baraban JM, Snyder SH, Alger BE (1985) Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters. Proc Natl Acad Sei USA 82:2538–2542
Barbin G, Palacios JM, Rodergas E, Schwartz JC, Garbarg M (1980) Characterization of the high-affinity binding sites of [3H]-histamine in rat brain. Mol Pharmacol 18:1–10
Batzri S, Harmon JW (1986) Is [3H]-tiotidine a specific ligand for the H2-receptor? Pharmacology 32:241–247
Batzri S, Harmon JW, Dyer J, Thompson WF (1982a) Interaction of histamine with gastric mucosal cells. Effect of histamine H2 antagonists on binding and biological response. Mol Pharmacol 22:41–47
Batzri S, Harmon JW, Thompson WF (1982b) Interaction of histamine with gastric mucosal cells. Effect of histamine agonists on binding and biological response. Mol Pharmacol 22:33–40
Batzri S, Harmon JW, Walker MD (1982c) Identification of [jH]-histamine binding sites on gastric mucosal cells unrelated to histamine H2-receptors. Biochem Biophys Res Commun 108:965–969
Baudry M, Martres MP, Schwartz JC (1975) Ηλ and H2 receptors in the histamineinduced accumulation of cyclic AMP in guinea pig brain slices. Nature 253: 362–363
Baudry M, Evans J, Lynch G (1986) Excitatory amino acids inhibit stimulation of phosphatidylinositol metabolism by aminergic agonists in hippocampus. Nature 319:329–331
Benardo LS, Prince DA (1982) Ionic mechanisms of cholinergic excitation in mammalian hippocampal pyramidal cells. Brain Res 249:333–344
Ben-Ari Y, Le Gal La Salle G, Barbin G, Schwartz JC, Garbarg M (1977) Histamine synthesizing afferents within the amygdaloid complex and bed nucleus of the stria terminalis of the rat. Brain Res 138:285–294
Bennett CT, Pert A (1974) Antidiuresis produced by injections of histamine into the cat supraoptic nucleus. Brain Res 78:151–156
Berridge MJ, Irvine RF (1984) Inositol triphosphate a novel second messenger in cellular signal transduction. Nature 312:315–321
Berridge MJ, Downes CP, Hanley MR (1982) Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J 206:587–595
Bhargava KP (1975) Some neuropharmacological studies with histamine. In: Boissier JR, Hippius H, Pichot P (eds) Neuropsychopharmacology. Excerpta Medica, Amsterdam, pp 597–604
Bharghava KP, Kulshresta VK, Santhakumri G, Srivastava YP (1973) Mechanism of histamine-induced antidiuretic response. Br J Pharmacol 47:700–706
Bielkiewicz B, Cook DA (1985) The binding of [3H]mepyramine to histamine Ηχ receptors in monkey brain. J Physiol Pharmacol 63:756–759
Black JW, Duncan WAM, Durant CJ, Ganellin CR, Parsons ME (1972) Definition and antagonism of histamine H2-receptors. Nature 236:385–390
Blakemore RC, Ganellin CR, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz JC, Tertiuk W, Theobald CJ (1987) Iodobolpyramine and other iodinated derivatives as ligands for detecting histamine Hx receptors. Eur J Med Chem 22:91–100
Bouthenet ML, Martres MP, Sales N, Schwartz JC (1987) A detailed mapping of dopamine D-2 receptors in rat central nervous system by autoradiography with [125I]iodosulpride. Neuroscience 20:117–155
Bouthenet ML, Ruat M, Sales N, Garbarg M, Schwartz JC (1988) A detailed mapping of histamine Hrreceptors in guinea-pig central nervous system established by autoradiography with [125I]iodobolpyramine. Neuroscience 26:553–600
Bradley PB (1968) Synaptic transmission in the CNS and its relevance for drug action. Int Rev Neurobiol 11:1–56
Bradley PB, Jones H, Roberts F (1984) Histamine potentiates the effects of excitatory amino acids on quiescent neurones in the rat medulla. Br J Pharmacol 82:195P
Bristow LJ, Bennett GW (1988a) A role for histamine H3 receptors in histamineinduced hypoactivity in the rat. Br J Pharmacol 94:319
Bristow LJ, Bennett GW (1988b) Biphasic effects of intraaccumbens histamine administration on spontaneous motor activity in the rat; a role for central histamine receptors. Br J Pharmacol 95:1292–1302
Bristow DR, Hare JR, Hearn JR, Martin LE (1981) Radioligand binding studies using [3H]-cimetidine and [3H]-ranitidine. Br J Pharmacol 74:547P
Brown E, Kendall DA, Nahorski SR (1984) Inositol phospholipid hydrolysis in rat cerebral cortical slices. I. Receptor characterization. J Neurochem 42:1379–1387
Burkard WP (1978) Histamine H2-receptor binding with [3H]-cimetidine in brain. Eur J Pharmacol 50:449–450
Buschauer A, Schunack W, Arrang JM, Garbarg M, Schwartz JC, Young JM (1989) Histamine receptors. In: Williams M, Glennon RA, Timmermans PBMWM (eds) Receptor pharmacology and function. Dekker, New York, pp 293–348
Calcutt CR, Ganellin CR, Jackson B, Leigh BK, Owen DAA, Smith IR (1987) Evidence for low brain penetration by the Hrreceptor antagonist temelastine (SK F 93944). Eur J Pharmacol 133:65–74
Carette B (1978) Responses of preoptic septal neurons to iontophoretically applied histamine. Brain Res 145:391–395
Carswell H, Nahorski SR (1982) Distribution and characteristics of histamine Hr receptors in guinea-pig airways identified by [3H]mepyramine. Eur J Pharmacol 81:301–307
Carswell H, Daum PR, Young JM (1985) Histamine Hi-agonist stimulated breakdown of inositol phospholipids. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 27–38
Carswell H, Galione AG, Young JM (1987) Differential effect of temperature on histamineand carbachol-stimulated inositol phospholipid breakdown in slices of guinea-pig cerebral cortex. Br J Pharmacol 90:175–182
Chang RSL, Snyder SH (1980) Histamine Hrreceptor binding sites in guinea pig brain membranes: regulation of agonist interactions by guanine nucleotides and cations. J Neurochem 34:916–922
Chang RSL, Tran VT, Snyder SH (1978) Histamine Hrreceptors in brain labeled with [3H]-mepyramine. Eur J Pharmacol 48:463–464
Chang RSL, Tran VT, Snyder SH (1979) Heterogeneity of histamine Hrreceptors: species variations in [3H]-mepyramine binding of brain membranes. J Neurochem 32:1653–1663
Chang RSL, Tran VT, Snyder SH (1980) Neurotransmitter receptor localizations: brain lesion induced alterations in benzodiazepine, GAB A, ß-adrenergic and histamine Hrreceptor binding. Brain Res 190:95–110
Chew CS (1985) Parietal cell protein kinases. Selective activation of type I cAMP-dependent protein kinase by histamine. J Biol Chem 260:7540–7550
Chew CS, Brown MR (1987) Histamine increases phosphorylation of 27 and 40-kDa parietal cell proteins. Am J Physiol 253:G823-G829
Chronister RP, Palmer GC, De France JF, Sikes RW, Hubbard JI (1982) Histamine: correlative studies in nucleus accumbens. J Neurobiol 13:23–38
Clark RB, Perkins JP (1971) Regulation of adenosine 3′,5′-monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine. Proc Natl Acad Sei USA 68:2757–2760
Claro E, Arbones L, Garcia A, Picatoste F (1986) Phosphoinositide hydrolysis mediated by histamine Ηχ-receptors in rat brain cortex. Eur J Pharmacol 123:187–196
Claro E, Garcia A, Picatoste F (1987) Histamine-stimulated phosphoinositide hydrolysis in developing rat brain. Mol Pharmacol 32:384–390
Codola R, Garcia A (1985) Effect of thyroid state on histamine Ηχ-receptors in adult and developing rat brain. Biochem Pharmacol 34:4131–4136
Cohen P, Burchell A, Foulkes JG, Cohen PTW (1978) Identification of the Ca2+-dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorlyase kinase. FEBS Lett 92:287–293
Crawford MLA, Young M (1988) GABAb receptor-mediated inhibition of histamine Ηχ-receptor induced inositol phosphate formation in slices of rat cerebral cortex. J Neurochem 51:1441–1447
Creveling CR, McNeal ET, McCulloch DH, Daly JW (1980) Membrane potentials in cell-free preparations from guinea pig cerebral cortex: effect of depolarizing agents and cyclic nucleotids. J Neurochem 35:922–932
Crook RB, Färber MB, and Prusiner SB (1986) H2 histamine receptors on the epithelial cells of choroid plexus. J Neurochem 46:489–493
Cybulsky DL, Kandel SI, Wells JW, Gornall AG (1981) Guanylylimidodiphosphate modulates [3H]histamine binding in a solubilised preparation from rat brain. Eur J pharmacol 72:407–409
Daly JW (1977) Cyclic nucleotides in the nervous system. Plenum, New York, pp 97–179
Daly JW, McNeal E, Partington C, Neuwirth M, Creveling CR (1980) Accumulations of cyclic AMP in adenine-labeled cell-free preparations from guinea pig cerebral cortex: role of α-adrenergic and Hi-histaminergic receptors. J Neurochem 35: 326–337
Daly JW, Padgett W, Seamon KB (1982) Activation of cyclic AMP-generating systems in brain membranes and slices by the diterpene forskolin: augmentation of receptor-mediated responses. J Neurochem 38:532–544
Dam Trung Tuong M, Garbarg M, Schwartz JC (1980) Pharmacological specificity of brain histamine H2-receptors differs in intact cells and cell-free preparations. Nature 287:548–551
Danoff S, Young JM (1987) Is histamine potentiation of adenosine-stimulated cyclic AMP accumulation in guinea-pig cerebral cortical slices mediated by products of inositol phospholipid breakdown? Biochem Pharmacol 36:1177–1179
Daum PR, Hill SJ, Young JM (1982) Histamine Ηχ-agonist potentiation of adenosine-stimulated cyclic AMP accumulation in slices of guinea-pig cerebral cortex: comparison of response and binding parameters. Br J Pharmacol 77: 347–357
Daum PR, Downes CP, Young JM (1983) Histamine-induced inositol phospholipid breakdown mirrors Ηχ-receptor density in brain. Eur J Pharmacol 87:497–498
Daum PR, Downes CP, Young JM (1984) Histamine stimulation of inositol 1- phosphate accumulation in lithium-treated slices from regions of guinea pig brain. J Neurochem 43:25–32
Devoto P, Marchisio AM, Carboni E, Spano PF (1980) Detection of [3H]-cimetidine specific binding in rat anterior pituitary. Eur J Pharmacol 63:91–93
Dismukes K, Rogers M, Daly JW (1976) Cyclic adenosine 3′,5′-monophosphate formation in guinea-pig brain slices: effect of Ηχand H2-histaminergic agonists. J Neurochem 26:785–790
Dogterom J, Van Wimersma Greidanus TB, De Wied D (1976) Histamine as an extremely potent releaser of vasopressin in the rat. Experientia 32:659–660
Donaldson J, Hill SJ (1986a) Histamine-induced hydrolysis of polyphosphoinositides in guinea-pig ileum and brain. Eur J Pharmacol 124:255–265
Donaldson J, Hill SJ (1986b) Enhancement of histamine Ηχ-receptor agonist activity by 1,4-dithiothreitol in guinea-pig cerebellum and cerebral cortex. J Neurochem 47:1476–1482
Donaldson J, Hill SJ (1987) 1,4-Dithiothreitol-induced changes in histamine Hr agonist efficacy and affinity in the longitudinal smooth muscle of guinea-pig ileum. Br J Pharmacol 90:263–271
Donaldson J, Brown AM, Hill S (1988) Influence of rolipram on the cyclic 3′,5′-adenosine monophosphate response to histamine and adenosine in slices of guinea-pig cerebral cortex. Biochem Pharmacol 37:715–723
Durant GJ, Ganellin CR, Parsons ME (1977) Dimaprit-(S-[3-(N, N-dimethylamino)- propyl]-isothiourea)-a highly specific histamine H2-receptor agonist. II. Structureactivity considerations. Agents Actions 7:39–43
Ea-Kim L, Oudart N (1988) A highly potent and selective H3 agonist relaxes rabbit middle cerebral artery, in vitro. Eur J Pharmacol 150:393–396
Edwards C, Nahorski SR, Rogers KJ (1974) In vivo changes of cerebral cyclic adenosine 3′,5′ monophosphate induced by biogenic amines: association with phosphorylase activation. J Neurochem 22:565–572
Foreman JC, Norris DB, Rising TJ, Webber SE (1985) The binding of [3H]tiotidine to homogenates of guinea pig lung parenchyma. Br J Pharmacol 86:475–482
Forn J, Krishna G (1971) Effect of norepinephrine, histamine and other drugs on cyclic 3′,5′-AMP formation in brain slices of various animals species. Pharmacology 5:193–204
Friedei RO, Schanberg SM (1975) Effect of histamine on phospholipid metabolism of rat brain in vivo. J Neurochem 24:819–820
Fukui H, Wang NP, Watanabe T, Wada H (1988) Solubilization, characterization and partial purification of [3H] mepyramine-binding protein, a possible histamine Hi receptor, from rat liver membrane. Jpn J Pharmacol 46:127–139
Gajtkowski GA, Norris DB, Rising TJ, Wood TP (1983) Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex. Nature 304:65–67
Ganellin CR (1982) Chemistry and structure activity relationship of drugs acting at histamine receptors. In: Ganellin CR, Parsons ME (eds) Pharmacology of histamine receptors. Wright, Bristol, pp 10–102
Ganellin CR (1985) A survey of recently described H2-receptor histamine antagonists. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 47–59
Ganellin CR, Schwartz JC (eds) (1985) Frontiers in histamine research. Pergamon, Oxford (Advances in the biosciences, vol 51)
Gannon MN, Hough LB (1986) Properties of a [3H]-adenine-prelabeled vesicular preparation from guinea pig cerebral cortex: optimization of incubation conditions for basal and histamine-stimulated [3H]-cAMP levels. J Pharmacol Methods 16:315–328
Gannon MN, Hough LB (1988) Histamine receptors coupled to [3H]-cAMP accumulation in brain: pharmacological characterization in a vesicular preparation of guinea pig cortex. Mol Pharmacol 33:44–50
Garbarg M, Schwartz JC (1988) Synergism between histamine Hr and H2-receptors in the cAMP response in guinea pig brain slices: effect of phorbol esters and calcium. Mol Pharmacol 33:38–43
Garbarg M, Barbin G, Feger J, Schwartz JC (1974) Histaminergic pathway in rat brain evidenced by lesions of the MFB. Science 186:833–835
Garbarg M, Barbin G, Palacios JM, Schwartz JC (1978) Effects of kainic acid on histaminergic systems in guinea pig hippocampus. Brain Res 150:638–641
Garbarg M, Yeramian E, Korner M, Schwartz JC (1985) Biochemical studies of cerebral Hrreceptors. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 19–25
Garbarg M, Trung Tuong MD, Gros C, Schwartz JC (1989) Effects of histamine H3-receptor ligands on various biochemical indices of histaminergic neuron activity in rat brain. Eur J Pharmacol 164:1–11
Gavish M, Chang RSL, Snyder SH (1979) Solubilization of histamine H1? GAB A and benzodiazepine receptors. Life Sei 2:783–790
Geller HM (1976) Effects of some putative neurotransmitters on unit activity of tuberal hypothalamic neurons in vitro. Brain Res 108:423–430
Geller HM (1979) Are histamine H2-receptor depressions of neuronal activity in tissue cultures from rat hypothalamus mediated through cyclic adenosine monophosphate? Neurosci Lett 14:49–53
Geller HM (1981) Histamine actions on activity of cultured hypothalamic neurons: evidence for mediation by Hr and H2-histamine receptors. Dev Brain Res 1:89–101
Green JP (1983) Histamine receptors in brain. In: Iversen L, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 17. Plenum, New York pp 385–420
Green JP (1987) Histamine receptors. In: Meitzer HY (ed) Psychopharmacology: the third generation of progress. Raven, New York, pp 273–279
Green JP, Maayani S (1977) Tricyclic antidepressant drugs block histamine H2- receptor in brain. Nature 269:163–165
Green JP, Johnson CL, Weinstein H, Maayani S (1977) Antagonism of histamine activated adenylate cyclase in brain by D-lysergic acid diethylamide. Proc Natl Acad Sei USA 74:5697–5701
Haas HL (1974) Histamine action on single hypothalamic neurons. Brain Res 76:363–366
Haas HL (1981) Histamine hyperpolarizes hippocampal neurones in vitro. Neurosci Lett 22:75–78
Haas HL (1984) Histamine in the central nervous system. Histamine potentiates neuronal excitation by blocking a calcium-dependent potassium conductance. Agents Actions 14:534–537
Haas HL (1985a) Histamine may act through cyclic AMP on hippocampal neurones. Agents Actions 16:234–235
Haas HL (1985b) Histamine action in the mammalian central nervous system. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 215–224
Haas HL (1985c) Histamine. In: Rogawski MA, Barker JL (eds) Neurotransmitter actions in the vertebrate nervous system. Plenum, New York, pp 321–337
Haas HL, Bucher UM (1975) Histamine H2-receptors on single central neurones. Nature 255:634–635
Haas HL, Greene RW (1986) Effects of histamine on hippocampal pyramidal cells of the rat in vitro. Exp Brain Res 62:123–130
Haas HL, Konnerth A (1983) Histamine and noradrenaline decrease calciumactivated potassium conductance in hippocampal pyramidal cells. Nature 302:432–433
Haas HL, Wolf P (1976) Possible histaminergic pathways in the cat and rat brain. Pflugers Arch 362:38
Haas HL, Wolf P (1977) Central actions of histamine: microelectrophoretic studies. Brain Res 122:269–279
Haas HL, Anderson EG, Hösli L (1973) Histamine and metabolites: their effects and interactions with convulsants on brain stem neurons. Brain Res 51:269–278
Haas HL, Hösli L, Anderson EG, Wolf P (1975) Action of histamine and metabolites on single neurones of the mammalian central nervous system. In: Boissier JR, Hippius H, Pichot P (eds) Neuropsychopharmacology. North-Holland, Amsterdam, pp 589–596
Haas HL, Wolf P, Palacios JM, Garbarg M, Barbin G, Schwartz JC (1978) Hypersensitivity to histamine in the guinea-pig brain: microiontophoretic and biochemical studies. Brain Res 156:275–291
Haas HL, Jefferys JGR, Slater NT, Carpenter DO (1984) Modulation of low calcium induced field bursts in the hippocampus by monoamines and cholinomimetics. Pflugers Arch 400:28–33
Hegstrand LR, Kanof PD, Greengard P (1976) Histamine sensitive adenylate cyclase in mammalian brain. Nature 260:163–165
Herkenham M (1987) Mismatches between neurotransmitter and receptor localizations in brain: observations and implications. Neuroscience 23:1–38
Hervatin F, Arrang JM, Bado A, Dubrasquet M, Lewin MJM (1988a) Involvement of histamine H3 receptors in pentagastrin stimulation of gastric acid secretion in the cat. Proc Chin Acad Sei 3:A25
Hervatin F, Dubrasquet M, Bado A, Lewin MJM (1988b) Histamine H3 receptors in the regulation of gastric acid secretion. Biomed Res 9:P216
Hill SJ (1987) Histamine receptors in the mammalian central nervous system: biochemical studies. Prog Med Chem 24:29–84
Hill SJ, Kendall DA (1987a) Adenosine augments histamine induced inositol phospholipid in guinea-pig cerebral cortical slices. Br J Pharmacol 89:771–775
Hill SJ, Kendall DA (1987b) Studies on the adenosine-receptor mediating the augmentation of histamine-induced inositol phospholipid hydrolysis in guinea-pig cerebral cortex. Br J Pharmacol 91:661–669
Hill SJ, Straw RM (1988) a2-Adrenoceptor-mediated inhibition of histamine release from rat cerebral cortical slices. Br J Pharmacol 95:1213–1219
Hill SJ, Young JM (1980) Histamine Hrreceptors in the brain of the guinea-pig and the rat: differences in ligand binding properties and regional distribution. Br J Pharmacol 68:687–696
Hill SJ, Young JM, Marrian DH (1977) Specific binding of 3H-mepyramine to histamine Hj receptors in intestinal smooth muscle. Nature 270:361–363
Hill SJ, Emson PC, Young JM (1978) The binding of [3H] mepyramine to histamine Hi receptors in guinea-pig brain. J Neurochem 31:997–1004
Hill SJ, Daum P, Young JM (1981) Affinities of histamine Hrantagonists in guinea pig brain: similarity of values determined from [3H] mepyramine binding and from inhibition of a functional response. J Neurochem 37:1357–1360
Hirata F, Axelrod J (1980) Phospholipid methylation and biological signal transmission. Science 209:1082–1090
Hoffman WE, Schmid PG (1978) Cardiovascular and antidiuretic effects of central histamine. Life Sei 22:1709–1714
Hokin LE (1985) Receptors and phosphoinositide generated second messengers. Annu Rev Biochem 54:205–235
Hollingsworth EB, Daly JW (1985) Accumulation of inositol phosphates and cyclic AMP in guinea-pig cerebral cortical preparations. Effects of norepinephrine, histamine carbamycholine and 2-chloroadenosine. Biochim Biophys Acta 847:207–216
Hollingsworth EB, McNeal ET, Burton JL, Williams RJ, Daly JW, Creveling CR (1985a) Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3′:5′-monophosphate-generating systems, receptors and enzymes. J Neurosci 5:2240–2253
Hollingsworth EB, Sears EB, Daly JW (1985b) An activator of protein kinase C (phorbol-12-myristate-13-acetate) augments 2-chloroadenosine elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations. FEBS Lett 184:339–342
Hollingsworth EB, De La Cruz RA, Daly JW (1986) Accumulations of inositol phosphates and cyclic AMP in brain slices: synergistic interactions of histamine and 2-chloroadenosine. Eur J Pharmacol 122:45–50
Hösli L, Hösli E (1988) Electrophysiologic and autoradiographic evidence for receptors for biogenic amines on astrocytes in explant cultures of rat CNS. In: Kimelberg HK (ed) Glial cell receptors. Raven, New York, pp 77–93
Hösli L, Hösli E, Schneider U, Wiget W (1984) Evidence for the existence of histamine Hr and H2-receptors on astrocytes of cultured rat central nervous system. Neurosci Lett. 48:287–291
Hough LB (1988) Cellular localization and possible functions for brain histamine: recent progress. Prog Neurobiol 30:469–505
Hough LB, Green JP (1984) Histamine and its receptors in the nervous system. In: Lajtha A (ed) Receptors in the nervous system, 2nd edn. Plenum, New York, pp 145–211 (Handbook of neurochemistry, vol 6)
Huang M, and Drummond GI (1979) adenylate cyclase in cerebral microvessels: action of guanine nucleotides, adenosine and other agonists. Mol Pharmacol 16:462–472
Ibrahim MZM (1975) Glycogen and its related enzymes of metabolism in the central nervous system. Adv Anat Embryol Cell Biol 52:1–85
Ichinose M, Stretton CD, Schwartz JC, Barnes PJ (1989) Histamine H3-receptors inhibit cholinergic neurotransmission in guinea pig airways. Br J Pharmacol 97: 13–15
Irvine RF, Letcher AJ, Dawson RMC (1984) Phosphatidylinositol-4,5-biphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Biochem J 218:177–185
Ishikawa S, Sperelakis N (1987) A novel class (H3) of histamine receptors on perivascular nerve terminals. Nature 327:158–160
Jafferji SS, Michell RH (1976) Stimulation of phosphatidylinositol turnover by histamine, 5-hydroxytryptamine and adrenaline in the longitudinal smooth muscle of guinea pig ileum. Biochem Pharmacol 25:1429–1430
Johnson CL (1984) Histamine receptors and cyclic nucleotides. In: Ganellin CR, Parsons ME (eds) Pharmacology of histamine receptors. Wright, Bristol, pp 146–216
Johnson CL, Sawutz DG (1985) Desensitization of histamine H2 receptors in human leukemia cells. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 79–88
Joiies H, Bradley PB, Roberts F (1985) Histamine-induced excitation of spontaneously active medullary neurones in the rat brain is mediated by H2-receptors. Neuropharmacology 24:1231–1239
Joo F, Rakonczay Z, Wollemann M (1975) cAMP-mediated regulation of the permeability in brain capillaries. Experientia 31:582–584
Jouvet M, Sakai K, Lin JS (1988) Role of histaminergic neurons in the regulation of arousal in the cat. Eur J Neurosci [Suppl]5
Kakiuchi S, Rail TW (1968) The influence of chemical agents on the accumulation of adenosine 3′-5′ monophosphate in slices of rabbit cerebellum. Mol Pharmacol 4:367–378
Kanba S, Richelson E (1983) Antidepressants are weak competitive antagonists of histamine H2 receptors in dissociated brain tissue. Eur J Pharmacol 94:313–318
Kanba S, Richelson E (1984) Histamine Ηχ receptors in human brain labelled with [3H] doxepin. Brain Res 304:1–7
Kandel SI, Steinberg GH, Wells JW, Kandel M, Gornall G (1980) Separate binding sites for histaminic drugs in rat cerebral cortex. Biochem Pharmacol 29:2269–2272
Kanof PD, Greengard P (1978) Brain histamine receptors as targets for antidepressant drugs. Nature 272:329–333
Kanof PD, Hegstrand LR, Greengard P (1977) Biochemical characterization of histamine-sensitive adenylate cyclase in mammalian brain. Arch Biochem Biophys 182:321–334
Karbon EW, Enna SJ (1984) Characterization of the relationship between γaminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain. Mol Pharmacol 27:53–59
Karnushina IL, Palacios JM, Barbin G, Dux E, Joo F, Schwartz JC (1980) Studies on a capillary-rich fraction isolated from brain: histaminic components and characterization of the histamine receptors linked to adenylate cyclase. J Neurochem. 34:1201–1208
Kendall DA, Hill SJ (1988) Adenosine inhibition of histamine-stimulated inositol phospholipid hydrolysis in mouse cerebral cortex. J Neurochem 50:497–502
Kendall DA, Nahorski SR (1984) Inositol phospholipid hydrolysis in rat cerebral cortical slices. II. Calcium requirement. J Neurochem 42:1388–1394
Kendall DA, Ferkany JW, Enna SJ (1980) Properties of 3H-cimetidine binding in rat brain membrane fractions. Life Sei 26:1293–1302
Khandelwal JK, Hough LB, Morrishow AM, Green JP (1982) Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma. Agents Actions 12:583–590
Kirsten EB, Sharma JN (1976) Microiontophoresis of acetylcholine, histamine and their antagonists on neurones in the medial and lateral vestibular nuclei of the cat. Neuropharmacology 15:743–753
Klein I, Levey GS (1971) Activation of myocardial adenyl cyclase by histamine in guinea-pig, cat and human heart. J Clin Invest 50:1012–1015
Kodama T, Matsukado Y, Shimizu H (1973) The cAMP system of human brain. Brain. Res 50:135–146
Körner M, Bouthenet ML, Ganellin CR, Garbarg M, Gros C, Ife RF, Sales N, Schwartz JC (1986) [125I]Iodobolpyramine, a highly sensitive probe for histamine Hrreceptors in guinea-pig brain. Eur J Pharmacol 120:151–160
Korte A, Myers J, Clark MA (1990) Characterization and tissue distribution of H3 histamine receptors in guinea pigs by Na-methylhistamine. Biochem Biophys Res Commun 168:979–986
Kuhar MJ (1985) The mismatch problem in receptor mapping studies. Trends Neurosci. 8:190–1
Kuno T., Kubo N, Tanaka C (1985) Molecular size of histamine Hi receptor determined by target size analysis. Biochem Biophys Res Commun 129:639–644
Kuo JF, Lee TP, Reyes PL, Walton KG, Donnelly TE Jr, Greengard P (1972) Cylcic nucleotide-dependent protein kinases. X. An assay method for the measurement of guanosine 3′,5′-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain. J Biol Chem 247:16–22
Lakoski JM, Aghajanian GK (1983) Effects of histamine, Hr and H2-receptor antagonists on the activity of serotonergic neurons in the dorsal raphe nucleus. J Pharmacol Exp Ther 227:517–523
Lakoski JM, Gallager DW, Aghajanian GK (1984) Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine: a reevaluation. Eur J Pharmacol 103:153–158
Le Fur G, Malgouris C, Uzan A (1981) Effect of mequitazine, a non-sedative antihistamine on brain Ηχ receptors. Life SCI 29:547–552
Leibowitz SF (1979) Histamine: modification of behavioral and physiological components of body fluid homeostasis. In: Yellin TD (ed) Histamine receptors. Spectrum, New York, pp 219–254
Levey GS, Klein I (1972) Solubilized myocardial adenylate cyclase. Restoration of histamine responsiveness by phosphatidy 1-serine. J Clin Invest 51:1578–1582
Lin JS, Sakai K, Jouvet M (1988) Evidence for histaminergic arousal mechanisms in the hypothalamus of cat. Neuropharmacology 27:111–122
Lin JS, Sakai K, Vanni-Mercier G, Arrang JM, Garbarg M, Schwartz JC, Jouvet M (1990) Involvement of histamine in arousal mechanisms demonstrated with H3- receptor ligands in the cat. Brain Res (in press)
Liou SY, Shibata S, Yamakawa K, Ueki S (1983) Inhibitory and excitatory effects of histamine on suprachiasmatic neurons in rat hypothalamic slice preparation. Neurosci Lett 41:109–113
Maayani S, Hough LB, Weinstein H, Green JP (1982) Response of the histamine H2-receptor in brain to antidepressant drugs. Adv Biochem Psychopharmacol 31:133–147
Magistretti PJ, Schorderet M (1985) Norepinephrine and histamine potentiate the increases in cyclic adenosine 3′:5′-monophosphate elicited by vasoactive intestinal polypeptide in mouse cerebral cortical slices: mediation by 1-adrenergic and Ηχ histaminergic receptors. J Neurosci 5:362–368
Magistretti PJ, Morrisson JH, Shoemaker WJ, Sapin V, Bloom FE (1981) Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism. Proc Natl Acad Sei USA 78:6535–6539
Malinowska DH, Sachs G, Cuppoletti J (1988) Gastric H+ secretion: histamine (cAMP-mediated) activation of protein phosphorylation. Biochim Biophys Acta 972:95–109
Martinez-Mir MI, Pollard H, Moreau J, Arrang JM, Ruat M, Traiffort E, Schwartz JC, Palacios JM (1990) Three histamine receptors (Ηχ, H2 and H3) visualized in the brain of human and non human primates. Brain Res (in press)
Marwaha J, Hoffer BJ, Freedman R (1981) Electrophysiologic evidence for histamine receptors in rat cerebellum. Exp Neurol 74:285–292
Matsumoto T, Kanaide H, Nishimura J, Shogakiuchi Y, Kobayashi S, Nakamura M (1986) Histamine activates Ηχ-receptors to induce cytosolic free calcium transients in cultured vascular smooth muscle cells from rat aorta. Biochem Biophys Res Commun 135:172–177
McNeill JH, Muschek LD (1972) Histamine effects on cardiac contractility, phosphorylase and adenyl cyclase. J Mol Cell Cardiol 4:611–624
Michell RH (1975) Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta 415:81–147
Nahorski SR, Rogers KJ (1975) The role of catecholamines in the action of amphetamine and L-dopa on cerebral energy metabolism. Neuropharmacology 14:283–290
Nahorski SR, Rogers KJ, Smith BM (1974) Histamine H2 receptors and cyclic AMP in brain. Life Sei 15:1887–1894
Nahorski SR, Rogers KJ, Edwards C (1975) Cerebral glycogenolysis and stimulation of ß-adrenoreceptors and histamine H2-receptors. Brain Res 92:529–533
Nahorski SR, Rogers KJ, Smith BM (1977) Stimulation of adenosine cyclic 3′:5′-monophosphate in chick cerebral hemisphere slices: effects of Ηχ and H2 histaminergic agonists and antagonists. Brain Res 126:387–390
Nakahata N, Martin MW, Hughes AR, Hepler JR, Harden K (1986) Ηχ-histamine receptors on human astrocytoma cells. Mol Pharmacol 29:188–195
Nemeth PR, Ort CA, Wood JD (1984) Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea-pig small intestine. J Physiol (Lond) 355:411–425
Nicoll RA, Madison DV, Lancaster B (1987) Noradrenergic modulation of neuronal excitability in mammalian hippocampus. In: Meitzer HY (ed) Psychopharmacology, the third generation of progress. Raven, New York, pp 105–112
Nielsen ST (1986) Binding of [3H] ICIA 5165, an H2-receptor antagonist to guinea-pig gastric mucosa. Agents Actions 18:524–531
Ninkovic M, Hunt SP (1985) Opiate and histamine Ηχ receptors are present on some substance P containing dorsal root ganglion cells. Neurosci Lett 53:133–137
Ninkovic M, Hunt SP, Gleave RW (1982) Localization of opiate and histamine Ηχ receptors in the primate sensory ganglia and spinal cord. Brain Res 241:197–206
Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 308:693–698
Norris DB, Gajtkowski GA, Rising TJ (1984) Histamine H2-binding studies in the guinea-pig brain. Agents Actions 14:543–545
Nowak JZ, Arrang JM, Schwartz JC, Garbarg M (1983) Interaction between mianserin, an antidepressant drug, and central Ηχ-and H2-histamine receptors: in vitro and in vivo studies and radioreceptor assay. Neuropharmacology 22:259–266
Oakes SG, Iaizzo PA, Richelson E, Powis G (1988) Histamine-induced intracellular free Ca++, inositol phosphates and electrical changes in murine N1E-115 neuroblastoma cells. J Pharmacol Exp Ther 247:114–121
Ohsako S, Deguchi T (1984) Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells. Biochem Biophys Res Commun 122:333–339
Oishi R, Itoh Y, Nishibori M, Saeki K (1989) Effects of the tystamine H3-agonist (R) a-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. J Neurochem 52:1388–1392
Olianas M, Oliver AP, Neff NH (1984) Correlation between histamine-induced neuronal excitability and activation of adenylate cyclase in the guinea pig hippocampus. Neuropharmacology 23:1071–1074
Ozawa K, Segawa T (1988) Histamine increases phospholipid methylation and H2-receptor-adenylate cyclase coupling in rat brain. J Neurochem 50:1551–1558
Ozawa K, Nomura Y, Segawa T (1987) Histamine acting on H2 receptors stimulates phospholipid methylation in synaptic membranes of rat brain. J Neurochem 48:1392–1398
Palacios JM, Garbarg M, Barbin G, Schwartz JC (1978a) Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea pig hippocampus. Mol Pharmacol 14:971–982
Palacios JM, Schwartz JC, Garbarg M (1978b) High affinity binding of 3H-histamine in rat brain. Eur J Pharmacol 50:443–444
Palacios JM, Young WS III, Kuhar MJ (1979) Autoradiographic localization of Ηχ-histamine receptors in brain using 3H-mepyramine: preliminary studies. Eur J Pharmacol 58:295–304
Palacios JM, Wamsley JK, Kuhar MJ (1981a) The distribution of histamine Hj-receptors in the rat brain: an autoradiographic study. Neuroscience 6:15–37
Palacios JM, Wamsley JK, Kuhar MJ (1981b) GABA benzodiazepine and histamine- Ηχ receptors in the guinea pig cerebellum: effects of kainic acid injections studied by autoradiographic methods. Brain Res 214:155–162
Palmer GC (1981) Regional distribution of neurohumoral responsive adenylate cyclase in rabbit brain microvessels. Neurosci Lett 21:207–210
Palmer GC, Palmer SJ (1978) 5′-Guanylyl-imidodiphosphate action on adenylate cyclase in homogenates of rat cerebral cortex plus neuronal and capillary fractions. Life Sei 23:207–216
Palmer GC, Chronister RB, Palmer SJ (1980) Adenylate cyclase responses to neurohumoral agonists in microvascular elements of the rat brain. J Neurobiol 11:503–508
Panula P, Yang HYT, Costa E (1984) Histamine-containing neurons in the rat hypothalamus. Proc Natl Acad Sei USA 81:2572–2576
Panula P, Pirvola U, Auvinen S, Airaksinen MS (1988) Histamine-immunoreactive nerve fibers in the rat brain. Neuroscience 28:585–610
Pellmar TC (1986) Histamine decreases calcium-mediated potassium current in guinea-pig hippocampal CA1 pyramidal cells. J Neurophysiol 55:727–738
Peroutka SJ, Snyder SH (1981) [ H]Mianserin: differential labeling of serotonin and histaminex receptors in rat brain. J Pharmacol Exp Ther 216(1): 142–148
Peroutka SJ, Moskowitz MA, Reinhard JF, Snyder SH (1980) Neurotransmitter receptor binding in bovine cerebral-micro vessels. Science 208:610–612
Phillis JW, Tebecis AK, York DH (1968) Histamine and some antihistamines: action on cerebral cortical neurones. Br J Pharmacol Chemother 33:426–440
Phillis JW, Kostopoulos GK, Odutola A (1975) On the specificity of histamine H2-receptor antagonists in the rat cerebral cortex. Can J Physiol Pharmacol 53:1205–1209
Pollard H, Schwartz JC (1987) Histamine neuronal pathways and their functions. Trends Neurosci 10:86–89
Pollard H, Bischoff S, Schwartz JC (1973) Decreased histamine synthesis in the rat brain by hypnotics and anaesthetics. J Pharm Pharmacol 25:920–922
Pollard H, Pachot I, Legrain P, Buttin G, Schwartz JC (1985) Development of a monoclonal antibody against L-histidine decarboxylase as a selective tool for the localisation of histamine synthesising cells. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 103–118
Portaleone P, Pagnini G, Crispino A, Genazzani E (1978) Histamine-sensitive adenylate cyclase in hypothalamus of rat brain: Ηχand H2-receptors. J Neurochem 31:1371–1374
Prell GD, Green JP (1986) Histamine as a neuroregulator. Annu Rev Neurosci 9:209–254
Psychoyos S (1978) Ηχand H2-histamine receptors linked to adenylate cyclase in cell-free preparations of guinea-pig cerebral cortex. Life Sei 23:2155–2162
Psychoyos S, Dove J, Strowbridge B, Nusynowitz I (1982) Highly activatable adenylate cyclase in 2-[3H]adenine-prelabeled vesicles prepared from guinea pig cerebral cortex by a simplified procedure. J Neurochem 38:1437–1445
Puil E, Spigelman I, Eisen A, Kim SU (1986) Electrophysiological responses of human spinal neurons in culture. Neurosci Lett 71:77–82
Quach TT, Rose C, Schwartz JC (1978) [3H]glycogen hydrolysis in brain slices: responses to neurotransmitters and modulation of noradrenaline receptors. J Neurochem 30:1335–1341
Quach TT, Duhemin AM, Rose C, Schwartz JC (1979) In vivo occupation of cerebral histamine Hi-receptors evaluated with 3H-mepyramine may predict sedative properties of psychotropic drugs. Eur J Pharmacol 60:391–392
Quach TT, Duchemin AM, Rose C, Schwartz JC (1980a) 3H-glycogen hydrolysis elicited by histamine in mouse brain slices: selective involvement of Ηχ receptors. Mol Pharmacol 17:301–308
Quach TT, Duchemin AM, Rose C, Schwartz JC (1980b) Labeling of histamine Ηχ-receptors in the brain of the living mouse. Neurosci Lett 17:49–54
Quach TT, Duchemin AM, Rose C, Schwartz JC (1981) Specific desensitization of histamine Ηχ receptor-mediated [3H]glycogen hydrolysis in brain slices. Mol Pharmacol 20:331–338
Quach TT, Rose C, Duchemin AM, Schwartz JC (1982) Glycogenolysis induced by serotonin in brain: identification of a new class of receptors. Nature 298:373–375
Quach TT, Duchemin AM, Rose C, Schwartz JC (1988) [ H]Glycogenolysis in brain slices mediated by ß-adrenoceptors: comparison of physiological response and [3H]dihydroalprenolol binding parameters. Neuropharmacology 27:629–635
Renaud LP (1976) Histamine microiontophoresis on identified hypothalamic neurons: 3 patterns of response in the ventromedial nucleus of the rat. Brain Res 115: 339–344
Richelson E (1978) Histamine Ηχ receptor-mediated guanosine 3′,5′-monophosphate formation by cultured mouse neuroblastoma cells. Science 201:69–71
Richelson E (1985) Histamine receptors, cyclic nucleotides and psychotic drugs. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 237–247
Rising TJ, Norris DB (1985) Histamine H2-receptor radioligand binding studies. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 61–68
Rising TJ, Norris DB, Warrander SE, Wood TP (1980) High affinity 3H-cimetidine binding in guinea-pig tissues. Life Sei 27:199–206
Roberts F, Calcutt CR (1983) Histamine and the hypothalamus. Neuroscience 9:721–739
Rodbell M (1980) The role of hormone receptors and GTP-regulatory proteins in membrane transduction. Nature 284:17–22
Rogers M, Dismukes KR, Daly JW (1975) Histamine-elicited accumulations of cyclic adenosine 3′,5′-monophosphate in guinea-pig brain slices: effect of Ηχand H2-antagonists. J Neurochem 25:531–534
Rose C, Quach TT, Llorens-Cortes C, Schwartz JC (1982) Relationship between occupation of cerebral Ηχ receptors and sedative properties of antihistamines. Arzneimitte forschung 3211(9A): 1171–1173
Rotter A, Frostholm A (1986) Cerebellar histamine Ηχ receptor distribution: an autoradiographic study of Purkinje cell degeneration, staggerer, weaver, and reeler mutant mouse strains. Brain Res Bull 16:205–214
Ruat M, Schwartz JC (1989) Photoaffinity labeling and electrophoretic identification of the Ηχ-receptor: comparison of several brain regions and animal species. J Neurochem 53:335–339
Ruat M, Korner M, Garbarg M, Gros C, Schwartz JC, Tertiuk W, Ganellin CR (1988) Characterization of histamine Ηχ-receptor binding peptides in guinea-pig brain using [125I]iodoazidophenpyramine, an irreversible specific photoaffinity probe. Proc Natl Acad Sei USA 85:2743–2747
Ruat M, Traiffort E, Bouthenet ML, Schwartz JC, Hirschfeld J, Buschauer A, Schunack W (1990a) Reversible and irreversible labeling and autoradiographic localisation of the cerebral histamine H2-receptor using [125I]iodinated probes. Proc Natl Acad Sei 87:1658–1662
Ruat M, Bouthenet ML, Schwartz JC, Ganellin CR (1990b) Histamine Ηχ-receptor in heart: unique electrophoretic mobility and autoradiographic localisation. J Neurochem 55:379–385
Sakai KK, Marks BH, George JM, Koestner A (1974) The isolated organ-cultured supraoptic nucleus as a neuropharamcological test system. J Pharmacol Exp Ther 190:482–491
Sastry BSR, Phillis JW (1976a) Depression of rat cerebral cortical neurones by Ηχ and H2 histamine receptor agonists. Eur J Pharmacol 38:269–273
Sastry BSR, Phillis JW (1976b) Evidence for an ascending inhibitory histaminergic pathway to the cerebral cortex. Can J Physiol Pharmacol 54:782–786
Satayavidad J, Kirsten EB (1977) Iontophoretic studies of histamine and histamine antagonists in the feline vestibular nuclei. Eur J Pharmacol 41:17–26
Schlicker E, Betz R, Gothert M (1988) Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol 337:588–590
Schlicker E, Fink K, Hinterthaner M, Göthert M (1989) Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3-receptors. Naunyn Schmiedebergs Arch Pharmacol 340:633–638
Schultz J, Daly J (1973) Accumulation of adenosine cyclic 3′:5′-monophosphate in cerebral cortical slices from rat and mouse: stimulatory effect of aand ß-adrenergic agents and adenosine. J Neurochem 21:1319–1326
Schunack W, Schwarz S, Gerhard G, Buyuktimkin S, Elz S (1985) Chiral agonists of histamine. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research. Pergamon, Oxford, pp 39–46
Schwartz JC (1975) Histamine as a transmitter in brain. Life Sei 17:503–518
Schwartz JC (1977) Histaminergic mechanisms in brain. Annu Rev Pharmacol Toxicol 17:325–339
Schwartz JC (1979) Histamine receptors in brain. Life Sei 25:895–912
Schwartz JC, Lampart C, Rose C (1970) Properties and regional distribution of histidine decarboxylase in rat brain. J Neurochem 17:1527–1534
Schwartz JC, Lampart C, Rose C, Rehault MC, Bischoff S, Pollard H (1971) Histamine formation in rat brain during development. J Neurochem 18:1787–1789
Schwartz JC, Barbin G, Garbarg M, Llorens-Cortes C, Palacios JM, Pollard H (1978) Histaminergic systems in brain. In: Simon P (ed) Neurotransmitters. Pergamon, Oxford, pp 171–180 (Advances in phamacology and therapeutics, vol 2)
Schwartz JC, Barbin G, Baudry M, Garbarg M, Martres MP, Pollard H, Verdiere M (1979a) Metabolism and functions of histamine in the brain. Curr Dev Psychopharmacol 5:173–261
Schwartz JC, Palacios JM, Barbin G, Quach TT, Garbarg M, Haas HL, Wolf P (1979b) Histamine receptors in mammalian brain: characteristics and modifications studied electrophysiologically and biochemically. In: Yellin TO (ed) Histamine receptors. Spectrum, New York, pp 161–183
Schwartz JC, Barbin G, Duchemin AM, Garbarg M, Llorens C, Pollard H, Quach TT, Rose C (1982a) Histamine receptors in the brain and their possible functions. In: Ganellin CR, Parsons ME (eds) Pharmacology of histamine receptors. Wright, Bristol, pp 351–391
Schwartz JC, Garbarg M, Lebrecht U, Nowak J, Pollard H, Rodergas E, Rose C, Quach TT, Morgat JL, Roy J (1982b) Histaminergic systems in brain: studies on localisation and actions. In: Uvnäs B, Tasaka K (eds) Advances in histamine research. Pergamon, Oxford, pp 71–80
Schwartz JC, Arrang JM, Garbarg M (1986a) Three classes of histamine receptors in brain. Trends Pharmacol Sei 7:24–28
Schwartz JC, Arrang JM, Garbarg M, Schunack W (1986b) Three classes of histamine receptors in brain: targets for novel drugs? In: Harms AF (ed) Innovative approaches in drug research. Elsevier, Amsterdam, pp 73–89
Schwartz JC, Garbarg M, Pollard H (1986c) Histaminergic transmission in the brain. In: Bloom FE, Mountcastle VB, Geiger SR (eds) The nervous system, vol 4 American Physiological Society, Bethesda, pp 257–316 (Handbook of physiology)
Schwartz JC, Arrang JM, Garbarg M, Pollard H, Ruat M (1990) Histaminergic transmission in the mammalian brain. Physiol Rev (in press)
Segal M (1980) Histamine produces a CA2+-sensitive depolarization of hippocampal pyramidal cells in vitro. Neurosci Lett 19:67–72
Segal M (1981) Histamine modulates reactivity of hippocampal CA3 neurons to afferent stimulation in vitro. Brain Res 213:443–448
Shimizu H, Crevelng C, Daly J (1970) Stimulated formation of adenosine cyclic 3′:5′-phosphate in cerebral cortex: synergism between electrical activity and biogenic amines. Proc Natl Acad Sei USA 65:1033–1040
Shimizu H, Tanaka S, Suzuki T, Matsukado Y (1971) The response of human cerebrum adenyl cyclase to biogenic amines. J Neurochem 18:1157–1161
Shonk RF, Rail TW (1987) Ontogeny of adenosine 3′,5′-monophosphate metabolism in guinea-pig cerebral cortex. I. Development of responses to histamine, norepinephrine and adenosine. Mol Cell Biochem 73:141–155
Siggins GR, Hoffer BJ, Bloom FE (1971) Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. III. Evidence for mediation of norepinephrine effects by cyclic 3′,5′-adenosine monophosphate. Brain Res 25:535–553
Smith IR, Cleverley MT, Ganellin CR, Metters KM (1980) Binding of [3H] cimetidine to rat brain tissue. Agents Actions 10:422–426
Smith IR, Leigh BK, Mylek ME (1986) [3H]-tiotidine binding to guinea-pig cortical and striatal membranes. Agents Actions. 19:169–173
Snider RM, McKinney M, Forray C, Richelson E (1984) Neurotransmitter receptors mediate cyclic GMP formation by involvement of arachidonic acid and lipoxygenase. Proc Natl Acad Sei USA 81:3905–3909
Steinberg GH, Eppel JG, Kandel M, Kandel SI, Wells JW (1985a) H2 histaminic receptors in rat cerebral cortex. I. Binding of [3H]histamine. Biochemistry 24: 6095–6107
Steinberg GH, Kandel M, Kandel SI, Wells JW (1985b) H2 histaminic receptors in rat cerebral cortex. II. Inhibition of [3H] histamine by H2 antagonists. Biochemistry 24:6107–6115
Steinberg GH, Kandel M, Kandel SI, Wells JW (1985c) H2 histaminic receptors in rat cerebral cortex. III. Inhibition of [3H] histamine by H2 agonists. Biochemistry 24:6115–6125
Steinbusch HWM, Mulder AH (1984) Immunohistochemical localization of histamine in neurons and mast cells in the rat brain. In: Björklund A, Hökfelt T, Kuhar MJ (eds) Classical transmitters and transmitter receptors in the CNS, part 2. Elsevier, Amsterdam, pp 126–140 (Handbook of Chemical neuroanatomy, vol 3)
Sterk GJ, van der Schaar MWG, Rademarker B, van der Goot H, Timmerman H (1986) Histamine H2-binding on guinea-pig cerebral cortex. Agents Actions 18:231–234
Study RE, Greengard P (1978) Regulation by histamine of cyclic nucleotide levels in sympathetic ganglia. J Pharmacol Exp Ther 207:767–778
Stüttgen G, Jacob W (1952) Die H-Substanzen des menschlichen liquors. Nervenarzt 23:60–63
Subramanian N, Mulder AH (1977) Modulation by histamine of the efflux of radiolabeled catecholamines from rat brain slices. Eur J Pharmacol 43:143–152
Subramanian N, Slotkin TA (1981) Solubilization of a [3H] cimetidine binding site from rat brain: a clonidine-sensitive H2 receptor subtype? Mol Pharmacol 20:240–243
Subramanian N, Whitmore WL, Seidler FJ, Slotkin TA (1980) Histamine stimulates brain phospholipid turnover through a direct H-l receptor-mediated mechanism. Life Sei. 27:1315–1319
Subramanian N, Whitmore WL, Seidler FJ, Slotkin TA (1981) Ontogeny of histaminergic neurotransmission in the rat brain: concomitant development of neuronal histamine, H-l receptors and H-l receptor-mediated stimulation of phospholipid turnover. J Neurochem 36:1137–1141
Tagami H, Sunami A, Akagi M, Tasaka T (1984) Effect of histamine on the hippocampal neurons in guinea-pigs. Agents Actions 14:538–542
Tamura K, Palmer JM, Wood JD (1988) Presynaptic inhibition produced by histamine at nicotinic synapses in enteric ganglia. Neuroscience 25:171–179
Taylor JE, Richelson E (1979) Desensitization of histamine Ηχ receptor-mediated cyclic GMP formation in mouse neuroblastoma cells. Mol Pharmacol 15:462–471
Taylor JE, Richelson E (1982) High-affinity binding of [3H]doxepin to histamine Ηχ-receptors in rat brain: possible identification of a subclass of histamine Hr receptors. Eur J Pharmacol 78:279–285
Taylor KM, Snyder SH (1971) Histamine in rat brain: sensitive assay of endogenous levels, formation in vivo and lowering by inhibitors of histidine decarboxylase. J Pharmacol Exp Ther 179:619–633
Toll L, Snyder SH (1982) Solubilization and characterization of histamine Ηχ receptors in brain. J Biol Chem 257:13593–13601
Tolone G, Bonasera L, Pontieri GM (1982) Histamine binding to H2-receptors stimulates phospholipid methylation in mast cells. Experientia 38:966–968
Tran VT, Chang RSL, Snyder SH (1978) Histamine Ηχ-receptors identified in mammalian brain membranes with [3H]mepyramine. Proc Natl Acad Sei USA 75:6290–6294
Tran VT, Freeman AD, Chang RSL, Snyder SH (1980) Ontogenetic development of histamine Ηχ-receptor binding in rat brain. J Neurochem. 34:1609–1613
Tran VT, Lebovitz R, Toll L, Snyder SH (1981) [3H]doxepin interactions with histamine Ηχ-receptors and other sites in guinea pig and rat brian homogenates. Eur J Pharmacol 70:501–509
Treherne JM, Young JM (1988a) [3H]-(+)-N-methyl-4-methyldi-phenphydramine, a quaternary radioligand for the histamine Ηχ-receptor. Br J Pharmacol 94:797–810
Treherne JM, Young JM (1988b) Temperature-dependence of the kinetics of the binding of [3H]-(+)-N-methyl-4-methyldi-phenhydramine to the histamine Ηχreceptor: comparison with the kinetics of [3H]-mepyramine. Br J Pharmacol 94:811–822
Trzeciakowski JP (1987) Inhibition of guinea-pig ileum contractions mediated by a class of histamine receptor resembling the H3 subtype. J Pharmacol Exp Ther 243:874–880
Tupmisto L, Eriksson L (1974) Central antidiuretic effect of histamine (H) in the unanesthetized goat; effects of Ηχ and H2 antagonists. J Pharmacol 5:101
Tuomisto L, Eriksson L (1979) Antidiuresis induced by infusions of histamine into the brain ventricles of conscious hydrated goats. Eur J Pharmacol 54:191–201
Tuomisto L, Eriksson L, Fyhrquist F (1980) Vasopressin release by histamine in the conscious goat. Eur J Pharmacol 63:15–24
Tuomisto L, Kilpelainen H, Riekkinen P (1983) Histamine and histamine-N- methyltransferase in the CSF of patients with multiple sclerosis. Agents Actions 13:255–257
Tuomisto L, Eriksson L, Fyhrquist F (1984) Plasma vasopressin levels after I.C.V. infusion of histamine agonists in the conscious goat. Agents Actions 14:558–560
Van der Vliet A, van der Werf JF, Bast A, Timmerman H (1988) Frequencydependent autoinhibition of histamine release from rat cortical slices: a possible role for H3 receptor reserve. J Pharm Pharmacol 40:577–579
Van der Werf JF, Bast A, Bijloo GJ, van der Vliet A, Timmerman H (1987a) HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulation. Eur J Pharmacol 138:199–206
Van der Werf JF, Bijloo GJ, van der Vliet A, Bast A, Timmerman H (1987b) H3 receptor assay in electrically-stimulated superfused slices of rat brain cortex; effects of Na-alkylated histamines and impromidine analogues. Agents Actions 20:239–243
Verdiere M, Rose C, Schwartz JC (1974) Synthesis and release of [3H]-histamine in slices from rat brain. Agents Actions 4:184–185
Verdiere M, Rose C, Schwartz JC (1975) Synthesis and release of histamine studied on slices from rat hypothalamus. Eur J Pharmacol 34:157–168
Ververken D, van Veldhoven P, Proost C, Carton H, de Wulf Η (1982) On the role of calcium ions in the regulation of glycogenolysis in mouse brain cortical slices. J Neurochem 38:1286–1295
Wallace RM, Young JM (1983) Temperature dependence of the binding of [3H]mepyramine and related compounds to the histamine Ηχ receptor. Mol Pharmacol 23:60–66
Wang NP, Fukui H, Matsuoka H, Wada H (1986) Determination of the molecular size of the hepatic Ηχ-receptor by target size analysis. Biochem Biophys Res Commun 137:593–598
Wang NP, Fukui H, Watanabe T, Wada H (1987) Solubilization and characterization of histamine Ηχ-receptor from guinea-pig brain. Biogenic Amines 4:7–17
Warrander SE, Norris DB, Rising TJ, Wood TP (1983) [3H]-cimetidine and the H2-receptor. Life Sei 33:1119–1126
Watanabe T, Taguchi Y, Hayashi H, Wada H, Kubota H, Terano Y, Tanaka J, Shiosaka S, Tohyama M (1983) Evidence for the presence of a histaminergic neuron system in the rat brain: an immunochemical analysis. Neurosci Lett 39:249–254
Wells JW, Cybulsky DL, Kandel M, Kandel SI, Steinberg GH (1985) Cognitive properties of H2-receptors revealed by [3H]histamine. In: Ganellin CR, Schwartz JC, (eds) Frontiers in histamine research. Pergamon, Oxford, pp 69–78
White T (1959) Formation and catabolism of histamine in brain tissue in vitro. J Physiol (Lon) 149:34–42
Wilcox BJ, Seybold VS (1982) Localization of neuronal histamine in rat brain. Neurosci Lett 29:105–110
Xu J, Chuang DM (1987) Serotonergic, adrenergic and histaminergic receptors coupled to phospholipase C in cultured cerebellar granule cells of rats. Biochem Pharmacol 14:2353–2358
Yeramian E, Garbarg M, Swhwartz JC (1985) N-Ethylmaleimide-induced changes in agonist affinity for histamine Ηχ-receptors in the guinea pig brain. Mol Pharmacol 28:155–162
Young CS, Mason R, Hill SJ (1988) Studies on the mechanism of histamine-induced release of noradrenaline and 5-hydroxytryptamine from slices of rat cerebral cortex. Biochem Pharmacol 37:2799–2805
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Schwartz, JC., Arrang, JM., Bouthenet, ML., Garbarg, M., Pollard, H., Ruat, M. (1991). Histamine Receptors in Brain. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-75840-9_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75842-3
Online ISBN: 978-3-642-75840-9
eBook Packages: Springer Book Archive