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Control of the Exocytotic Mechanism in Rat Mast Cells

  • Chapter
Histamine and Histamine Antagonists

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 97))

Abstract

The granular appearance of the mast cell (and the closely related blood basophil) tells us immediately that this is a cell highly specialised for secretion and for this reason it has been widely used as one of the prime model systems in the investigation of the secretory process. It is, however, only a few years since the argument about whether the degranulation reaction is conventionally exocytotic (i.e. non-lytic, involving selective fusion of granule and plasma membrane) was settled with the demonstration that histamine is released from stimulated cells while K+ and lactate dehydrogenase are retained (Johnson and Moran 1969).

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  1. B. D. Gomperts
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  1. Department of Pharmacology, Karolinska Institutet, Box 60400, S-104 01, Stockholm, Sweden

    Börje Uvnäs M.D.

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Gomperts, B.D. (1991). Control of the Exocytotic Mechanism in Rat Mast Cells. In: Uvnäs, B. (eds) Histamine and Histamine Antagonists. Handbook of Experimental Pharmacology, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75840-9_12

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  • DOI: https://doi.org/10.1007/978-3-642-75840-9_12

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