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Neuropeptide Y: A Novel Peptidergic Signal for the Control of Feeding Behavior

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Behavioral Aspects of Neuroendocrinology

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 10))

Abstract

Man’s fascination with the elements that evoke pleasurable indulgence or, alternatively, attenuate or cause cessation of food intake dates back to the dawn of civilization. The cultural perception of obesity has vacillated across times and civilizations. For this, if for no other, reason the inevitability of a connection between eating and obesity and the fascination with a lean body image are preeminent in conventional wisdom today throughout the Western world.

The research summarized in this review was supported by grants from the National Institutes of Health (HD 08634 and DK 37273).

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References

  • Agnati LF, Rixe K, Benfenati F, Battistini N, Harfstrand A, Tatemoto K, Hökfelt T, Mutt V (1983) Neuropeptide Y in vitro selectively increases the number of α 2-adrenergic binding sites in membranes of the medulla oblongata of the rat. Acta Physiol Scand 118:293–295

    PubMed  CAS  Google Scholar 

  • Allen JM (1989) Molecular structure of neuropeptide Y and regulation of expression of its gene. In: Mutt V, FĂĽxe K, Hökfelt T, Lundberg J (eds) Neuropeptide Y. Raven, New York, pp 33–41

    Google Scholar 

  • Allen LG, Kalra PS, Crowley WR, Kalra SP (1985) Comparison of the effect of neuropeptide Y and adrenergic transmitters on LH release and food intake in male rats. Life Sci 37:617–623

    PubMed  CAS  Google Scholar 

  • Allen YS, Adrian TE, Allen JM, Tatemoto K, Crow TJ, Bloom SR, Polak JM (1983) Neuropeptide Y distribution in the rat brain. Science 221:877–879

    PubMed  CAS  Google Scholar 

  • Antin J, Gibbs J, Holt J, Young RC, Smith GP (1975) Cholecystokinin elicits the complete behavioral sequence of satiety in rats. J Comp Physiol Psychol 89:784–790

    PubMed  CAS  Google Scholar 

  • Aravich PF, Sclafani A, Leibowitz SF (1982) Effects of hypothalamic knife cuts on feeding induced by paraventricular norepinephrine injections. Pharmacol Biochem Behav 16:101–111

    PubMed  CAS  Google Scholar 

  • Armstrong S (1980) A chronometric approach to the study of feeding behavior. Neurosci Biobehav Rev 4:17–53

    Google Scholar 

  • Bai FL, Yamona M, Shiotani Y, Emson PC, Smith AD, Powell JF, Tahyama M (1985) An arcuatoparaventricular and dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenalin in the rat. Brain Res 331:172–175

    PubMed  CAS  Google Scholar 

  • Balagura S, Coscina DV (1968) Periodicity of food intake in the rat as measured by an operant response. Physiol Behav 3:641–643

    Google Scholar 

  • Balasubramaniam AI, Grupp L, Srivastava L, Tatemoto K, Murphy RF, Joffe SN, Fischer JE (1987) Synthesis of neuropeptide Y. Int J Pept 29:78–83

    CAS  Google Scholar 

  • Bendotti C, Garattini S, Samanin R (1987) Eating caused neuropeptide Y injection in the paraventricular hypothalamus: Response to (+)-fenfluramine and (+)-amphetamine in rats. J Pharmacol 39:900–903

    CAS  Google Scholar 

  • Blundell JE (1981) Bio-grammar of feeding: pharmacological manipulations and their interpretations. In: Cooper SJ (ed) Theory in psychopharmacology. Academic, New York, pp 233–276

    Google Scholar 

  • Booth DA (1971) Some characteristics of feeding during streptozotocin-induced diabetes in the rat. J Comp Physil Psychol 80:238–249

    Google Scholar 

  • Brobeck JE (1946) Mechanisms of the development of obesity in animals with hypothalamic lesions. Psychol Rev 26:541–559

    CAS  Google Scholar 

  • Carpenter RG, Grossman SP (1983) Early streptozocin-diabetes and hunger. Physiol Behav 31:175–178

    PubMed  CAS  Google Scholar 

  • Chan-Palay V, Yasargil G, Hamid Q, Polak JM, Palay SL (1988) Simultaneous demonstrations of neuropeptide Y gene expression and peptide storage in single neurons of the human brain. Proc Natl Acad Sci USA 85:3213–3215

    PubMed  CAS  Google Scholar 

  • Chronwall BM, DiMaggio DA, Massari VJ, Vickel VM, Ruggiero DA, O’Donohue TL (1985) The anatomy of neuropeptide Y-containing neurons in the rat brain. Neuroscience 15:1159–1181

    PubMed  CAS  Google Scholar 

  • Clark JT, Kalra PS, Crowley WR, Kalra SP (1984) Neuropeptide Y and human pancreatic polypeptide stimulates feeding behavior in rats. Endocrinology 115:427–429

    PubMed  CAS  Google Scholar 

  • Clark JT, Kalra PS, Kalra SP (1985) Neuropeptide Y stimulates feeding but inhibits sexual behavior in male rats. Endocrinology 117:2435–2442

    PubMed  CAS  Google Scholar 

  • Clark JT, Sahu A, Kalra PS, Balasubramaniam A, Kalra SP (1987) Neuropeptide Y (NPY)-induced feeding behavior in female rats: comparison with human NPY (methionine-17-NPY), NPY analog (norleucine 4-NPY) and peptide YY. Regul Pept 17:31–39

    PubMed  CAS  Google Scholar 

  • Clark JT, Gist RS, Kalra SP, Kalra PS (1988) α 2-adrenoceptor blockade attenuates feeding behavior induced by neuropeptide Y and epinephrine. Physiol Behav 43:417–422

    PubMed  CAS  Google Scholar 

  • Cordor R, Emson PC, Lowry PJ (1984) Purification and characterization of human neuropeptide Y from adrenal-medullary phaeochromocytoma tissue. Biochem J 219:699–706

    Google Scholar 

  • Everitt BJ, Hökfelt T (1989) The coexistence of neuropeptide Y with other peptides and amines in the central nervous system. In: Mutt V, FĂĽxe K, Hökfelt T, Lundberg J (eds) Neuropeptide Y. Raven, New York, pp 61–72

    Google Scholar 

  • Everitt BJ, Hökfelt T, Terenius L, Tatemoto K, Mutt V, Goldstein M (1984) Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 11:443–462

    PubMed  CAS  Google Scholar 

  • FĂĽhlendorff J, Gether U, Aakerlund L, Johansen NL, Thogersen H, Melberg SG, Olsen UB, Thastrup O, Schwartz TW (1989) [Leu31, Pro34] neuropeptide Y — a specific Y1 receptor agonist. Biochemistry (in press)

    Google Scholar 

  • FĂĽxe K, Härfstrand A, Agnati LF, von Euler G, Svensson T, Fredholm B (1989) On the role of NPY in central cardiovascular regulation. In: Mutt V, FĂĽxe K, Hökfelt T, Lundberg J (eds) Neuropeptide Y. Raven, New York, pp 201–214

    Google Scholar 

  • Gehlert DR, Chronwall BM, Schafer MD, O’Donohue TL (1987) Localization of neuropeptide Y messenger ribonucleic acid in rat and mouse brain by in situ hybridization. Synapse 1:25–31

    PubMed  CAS  Google Scholar 

  • Gibbs J, Smith GP (1984) The heuroendocrinology of postprandial satiety. Front Neuroendocrinol 8:223–245

    CAS  Google Scholar 

  • Gibbs J, Young RC, Smith GP (1973) Cholecystokinin elicits satiety in rats with open gastric fistulas. Nature 245:323–325

    PubMed  CAS  Google Scholar 

  • Gibbs J, Fauser DJ, Rowe EA, Rolls BJ, Rolls ET, Maddison SP (1979) Bombesin suppresses feeding in rats. Nature 282:208–210

    PubMed  CAS  Google Scholar 

  • Goldstein M, Kusano N, Adler C, Meller E (1986) Characterization of central neuropeptide receptor binding sites and possible interactions with a2-adrenoreceptors. Prog Horm Res 68:331–335

    CAS  Google Scholar 

  • Gustafsson J-A, Carlstedt-Duke J, Poellinger L, Okret S, Wikström A-C, Brönnegârd M, Gillner M, Dong Y, FĂĽxe K, Cintra A, Härfstrand A, Agnati L (1987) Biochemistry, molecular biology, and physiology of the glucocorticoid receptor. Endocr Rev 8:185–234

    PubMed  CAS  Google Scholar 

  • Härfstrand A, Cintra A, FĂĽxe K, Aronsson M, Wikström A-C, Okret S, Gustafsson J-A, Agnati LF (1989a) Regional differences in glucocorticoid receptor immunoreactivity among neuropeptide Y immunoreactive neurons of the rat brain. Acta Physiol Scand 135:3–9

    Google Scholar 

  • Härfstrand A, FĂĽxe K, Agnati L, Fredholm B (1989b) Reciprocal interactions between α 2-adrenoceptor agonist and neuropeptide Y binding sites in the nucleus tractus solitarious of the rat. A biochemic and autoradiographic analysis. J Neural Transm 75:83–99

    Google Scholar 

  • Havrankova J, Roth J, Brownstein M (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272:827–829

    PubMed  CAS  Google Scholar 

  • Heilig M, Wahlestedt C, Widerlov E (1988) Neuropeptide Y (NPY)-induced suppression of activity in the rat: evidence for NPY receptor heterogeneity and for interaction with a-receptors. Eur J Pharmacol 157:205–213

    PubMed  CAS  Google Scholar 

  • Hökfelt T, FĂĽxe K, Goldstein M, Johansson O (1974) Immunohistochemical evidence for the existence of adrenalin neurons in the rat brain. Brain Res 66:235–251

    Google Scholar 

  • Hökfelt T, Johansson O, Goldstein M (1984) Chemical anatomy of the brain. Science 225:1326–1334

    PubMed  Google Scholar 

  • Hökfelt T, Tsuruo Y, Meister B, Melaner T, Schalling M, Everitt B (1987) Localization of neuroactive substances in the hypothalamus with special reference to coexistence of messenger molecules. In: Mahesh VB, Dhindsa DS, Anderson E, Kalra SP (eds) Regulation of ovarian and testicular function. Plenum, New York, pp 21–46

    Google Scholar 

  • Kalra SP, Crowley WR (1984) Differential effects of pancreatic polypeptide on luteinizing hormone release in female rats. Neuroendocrinology 38:511–513

    PubMed  CAS  Google Scholar 

  • Kalra SP, Crowley WR, Kalra PS (1986a) Different modes of NPY receptor activation may regulate LH secretion and feeding behavior. Soc Neurosci Abstr 12:1494

    Google Scholar 

  • Kalra SP, Allen LG, Clark JT, Crowley WR, Kalra PS (1986b) Neuropeptide Y — an integrator of reproductive and appetitive functions. In: Moody TW (ed) Neural and endocrine peptides and receptors. Plenum, New York, pp 353–366

    Google Scholar 

  • Kalra SP, Dube MG, Kalra PS (1988a) Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: effects of adrenalectomy and cholecystokinin. Peptides 9:723–728

    CAS  Google Scholar 

  • Kalra SP, Clark JT, Sahu A, Dube MG, Kalra PS (1988b) Control of feeding and sexual behaviors by neuropeptide Y: physiological implications. Synapse 2:254–257

    CAS  Google Scholar 

  • Kalra SP, Clark JT, Sahu A, Kalra PS, Crowley WR (1989) Hypothalamic NPY: a local circuit in the control of reproduction and behavior. In: Mutt V, FĂĽxe K, Hökfelt T, Lundberg J (eds) Neuropeptide Y. Raven, New York, pp 229–241

    Google Scholar 

  • Kuenzel WJ, Douglass LW, Davison BA (1987) Robust feeding following central administration of neuropeptide Y or peptide YY in chicks, Gallus domesticus. Peptides 8:823–828

    PubMed  CAS  Google Scholar 

  • Kulkosky PJ, Glazner GW, Moore HD, Low CA, Woods SC (1989) Neuropeptide Y: behavioral effects in the golden hamster. Peptides 9:1389–1393

    Google Scholar 

  • Larhammar D, Ericsson A, Persson H (1987) Structure and expression of the rat neuropeptide Y gene. Proc Natl Acad Sci USA 84:2068–2072

    PubMed  CAS  Google Scholar 

  • Leibowitz SF (1975) Pattern of drinking and feeding produced by hypothalamic norepinephrine injection in the satiated rat. Physiol Behav 14:731–742

    PubMed  CAS  Google Scholar 

  • Leibowitz SF (1978) Paraventricular nucleus: a primary site mediating adrenergic stimulation of feeding and drinking. Pharmacol Biochem Behav 8:163–175

    PubMed  CAS  Google Scholar 

  • Leibowitz SF (1980) Neurochemical systems of the hypothalamus, control of feeding and drinking behavior and water-electrolyte excretion. In: Morgane P, Pankskeep J (eds) Handbook of the hypothalamus, vol 3. Dekker, New York, pp 299–437

    Google Scholar 

  • Leibowitz SF, Roossin P, Roseun M (1984) Chronic norepinephrine injection into the hypothalamic paraventricular nucleus produces hyperphagia and increased body weight in the rat. Pharmacol Biochem Behav 21:801–808

    PubMed  CAS  Google Scholar 

  • Levine AS, Morley JE (1984) Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5:1025–1029

    PubMed  CAS  Google Scholar 

  • Louis-Sylvestre J, Le Magnen J (1980) A fall in blood glucose levels precedes meal onset in pre-feeding rats. Neurosci Biobehav Rev 4 [Suppl]:s13-s16

    Google Scholar 

  • Lundberg JM, Hökfelt T, Anggard A, Kimmel J, Goldstein M, Markey K (1980) Coexistence of avian pancreatic polypeptide (APP) immunoreactive substance and catecholamines in some peripheral and central neurons. Acta Physiol Scand 110:107–109

    PubMed  CAS  Google Scholar 

  • Lundberg JM, Pernow J, Lacroix S, Franco-Cereceda A, Rudehill A, Hökfelt T (1989) Neuropeptide tyrosine (NPY) and sympathetic cardiovascular control. In: Mutt V, FĂĽxe K, Hökfelt T, Lundberg J (eds) Neuropeptide Y. Raven, New York, pp 191–200

    Google Scholar 

  • Magdalin W, Stanley BG, Fournier A, Leibowitz SF (1989) A structure-activity analysis of neuropeptide Y-induced eating behavior. Soc Neurosci Abstr 15:895

    Google Scholar 

  • Martel J-C, Pierre S, Quirion R (1986) Neuropeptide Y receptors in rat brain: autoradiographic localization. Peptides 7:55–60

    PubMed  CAS  Google Scholar 

  • Minth C, Dixon JE (1989) Regulation of neuropeptide Y gene expression. In: Mutt VE, FĂĽxe K, Hökfelt T and Lundberg J (eds) Neuropeptide Y. Raven, New York, pp 13–21

    Google Scholar 

  • Minth C, Bloom S, Polak J, Dixon J (1984) Cloning, characterization and DNA sequence of human cDNA encoding neuropeptide tyrosine. Proc Natl Acad Sci USA 81:4577–4581

    PubMed  CAS  Google Scholar 

  • Morley JE (1987) Neuropeptide regulation of appetite and weight. Endocr Rev 8:256–287

    PubMed  CAS  Google Scholar 

  • Morley JE, Levine AS, Grace M, Keip J (1985) Peptide YY (PYY), a potent orexigenic agent. Brain Res 341:200–203

    PubMed  CAS  Google Scholar 

  • Morley JE, Levine AS, Willenbring M (1986) Stress-induced feeding disorders. In: Carruba MO, Blundell JE (eds) Pharmacology of eating disorders: theoretical and clinical developments. Raven, New York, pp 71–100

    Google Scholar 

  • Morley JE, Hernandez EN, Flood JF (1987a) Neuropeptide Y increases food intake in mice. Am J Physiol 253:R516–R522

    CAS  Google Scholar 

  • Morley JE, Levine AS, Gosnell BA, Kneip J, Grace M (1987b) Effect of neuropeptide Y on ingestive behaviors in the rat. Am J Physiol 252:R599–R609

    CAS  Google Scholar 

  • Mutt V (1989) NPY: the background. In: Mutt V, FĂĽxe K, Hökfelt T, Lundberg J (eds) Neuropeptide Y. Raven, New York, pp 1–12

    Google Scholar 

  • Nizielski SE, Levine AS, Gosnell BA, Morley JE, Seal US (1985) The effect of neuropeptide Y (NPY) and norepinephrine (NE) on feeding in hypophagic ground squirrels. Fed Proc 44:545

    Google Scholar 

  • Olschowka JA, O’Donohue TL, Jacobowitz DM (1981) The distribution of bovine pancreatic polypeptide-like immunoreactive neurons in rat brain. Peptides 2:309–331

    PubMed  CAS  Google Scholar 

  • O’Hare MMT, Tenmoke S, Aakerlund L, Hilsted L, Johnsen A, Schwartz TW (1988) Neuropeptide Y in guinea pig, rabbit, rat and man. Identical amino acid sequence and oxidation of methionine 17. Regul Pept 20:293–304

    PubMed  Google Scholar 

  • Pappas TW, Debas HT, Melendez R-L, Taylor IL (1986) Central neuropeptide Y stimulates food intake and delays gastric emptying in dogs. Gastroenterology 90:1578 (abstract)

    Google Scholar 

  • Parrott RF, Heavens RP, Baldwin BA (1986) Stimulation of feeding in satiated pigs by intracerebroventricular injection of neuropeptide Y. Physiol Behav 36:523–525

    PubMed  CAS  Google Scholar 

  • Pau M-YC, Pau KYF, Spies HG (1988) Characterization of central actions of neuropeptide Y on food and water intake in rabbits. Peptides 44:797–802

    CAS  Google Scholar 

  • Raiteri M, Maura G, Versace P (1983) Functional evidence for two stereochemically different a2-adrenoreceptors regulating central norepinephrine and serotonin release. J Pharmacol Exp Ther 224:679–684

    PubMed  CAS  Google Scholar 

  • Rosewasser AM, Boulos Z, Terman M (1981) Circadian organization of food intake and meal patterns in the rat. Physiol Behav 27:33–39

    Google Scholar 

  • Rowland NE (1988) Peripheral and central satiety factors in neuropeptide Y-induced feeding in rats. Peptides 9:989–992

    PubMed  CAS  Google Scholar 

  • Sahu A, Kalra PS, Crowley WR, Kalra SP (1987) Site specific changes in neuropeptide Y (NPY) levels in the hypothalamus: effects of castration and adrenalectomy. Endocr Soc Abstr, p 204

    Google Scholar 

  • Sahu A, Kalra PS, Kalra SP (1988a) Food deprivation and ingestion induce reciprocal changes inneuropeptide Y concentrations in the paraventricular nucleus. Peptides 9:83–86

    CAS  Google Scholar 

  • Sahu A, Kalra PS, Dube MG, Kalra SP (1988b) Neuropeptide K suppresses feeding in the rat. Regul Pept 23:135–143

    CAS  Google Scholar 

  • Sahu A, Kalra SP, Crowley WR, Kalra PS (1988c) Evidence that NPA-containing neurons in the brain stem project into selected hypothalamic nuclei: implication in feeding behavior. Brain Res 457:376–378

    CAS  Google Scholar 

  • Sahu A, Dube M, Kalra SP (1989) Bilateral neural transections at the level of mesencephalon increase food intake and reduce latency to onset of feeding in response to neuropeptide Y. Peptides 9:1269–1273

    Google Scholar 

  • Sahu A, Sninsky CA, Kalra PS, Kalra SP, Kalra PS (1990) Neuropeptide Y concentrations in microdissected hypothalamic regions and in vitro release from the medial basal hypothalamuspreoptic area of streptozotocin-diabetic rats with and without insulin substitution therapy. Endocrinology 126:192–198

    PubMed  CAS  Google Scholar 

  • Sawchenko PE, Swanson LW, Grzanna R, Howe PRC, Bloom SR, Polak JM (1985) Colocalization of neuropeptide Y immunoreactivity in brain stem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 241:138–153

    PubMed  CAS  Google Scholar 

  • Sheikh SP, Hakanson R, Schwartz TW (1989) Y1 and Y2 receptors for neuropeptide Y. FEBS Lett 245:209–214

    PubMed  CAS  Google Scholar 

  • Shimizu H, Bray GA (1989) Effects of neuropeptide Y on norepinephrine and serotonin metabolism in rat hypothalamus in vivo. Brain Res Bull 22:945–950

    PubMed  CAS  Google Scholar 

  • Siegel PS (1961) Food intake in the rat in relation to the light-dark cycle. J Comp Physiol Psychol 54:294–300

    Google Scholar 

  • Stanley BG, Leibowitz SF (1984) Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci 35:2635–2642

    PubMed  CAS  Google Scholar 

  • Stanley BG, Leibowitz SF (1985) Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc Natl Acad Sci USA 82:3940–3943

    PubMed  CAS  Google Scholar 

  • Stanley BG, Chin AS, Leibowitz SF (1985a) Feeding and drinking elicited by central injection of neuropeptide Y: evidence for hypothalamic site(s) of action. Brain Res Bull 14:521–524

    CAS  Google Scholar 

  • Stanley BG, Daniel DR, Chin AS, Leibowitz SF (1985b) Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6:1205–1211

    CAS  Google Scholar 

  • Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF (1986a) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:1189–1192

    CAS  Google Scholar 

  • Stanley BG, Lanthier D, Chin AS, Leibowitz SF (1986b) Feeding elicited by paraventricular nucleus injection of neuropeptide Y: a role of circulating corticosterone. Soc Neurosci Abstr 12:592

    Google Scholar 

  • Stanley BG, Magdalin W, Leibowitz SF (1989) A critical site for neuropeptide Y-induced eating lies in the caudolateral paraventricular/perifornical region of the hypothalamus. Soc Neurosci Abstr 15:894

    Google Scholar 

  • Steinman JL, Gunion M, Morley JE (1987) Third and fourth ventricular (3V, 4V) neuropeptide Y (NPY) stimulates feeding and drinking in rats. Fed Proc 46:1125

    Google Scholar 

  • Tatemoto K (1982a) Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA 79:5485–5489

    CAS  Google Scholar 

  • Tatemoto K (1982b) Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci USA 79:2514–2518

    CAS  Google Scholar 

  • Tatemoto K (1989) Neuropeptide Y: isolation, structure and function. In: Mutt V, Ftixe K, Hökfelt T, Lundberg J (eds) Neuropeptide Y, Raven, New York, pp 23–32

    Google Scholar 

  • Tatemoto K, Carlquist M, Mutt V (1982) Neuropeptide Y — a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296:659–660

    PubMed  CAS  Google Scholar 

  • Tatemoto K, Lundberg JM, Jornvall H, Mutt V (1985) Neuropeptide K: isolation, structure and biological activities of a novel brain tachykinin. Biochem Biophys Res Commun 128:947–953

    PubMed  CAS  Google Scholar 

  • Tempel DL, Bhakthavatsalam P, Shor-Posner G, Dwyer D, Leibowitz SF (1985) Nutrient self-selection at different periods of the light-dark cycle in free feeding and food deprived rats. Proc East Psychol Assoc Abstr 56:10

    Google Scholar 

  • Valentino KL, Tatemoto K, Hunter J, Barchas JD (1986) Distribution of neuropeptide K-immunoreactivity in the rat central nervous system. Peptides 7:1043–1059

    PubMed  CAS  Google Scholar 

  • Wahlestedt C, Yanaihara N, Häkanson R (1986) Evidence for different pre-and post-junctional receptors for neuropeptide Y and related peptides. Regul Pept 13:317–328

    Google Scholar 

  • White JD, Olchorskey D, Kershaw M (1989) Hypothalamic content of prepro-neuropeptide Y mRNA is increased in diabetic rats. Endocr Soc Abstr, p 37

    Google Scholar 

  • Williams G, Steel JH, Cardoso H, Ghatei MA, Lee Y-C, Gill JS, Burrin JM, Polak JM, Bloom SR (1988) Increased hypothalamic neuropeptide Y concentrations in diabetic rat. Diabetes 37:763–772

    PubMed  CAS  Google Scholar 

  • Williams G, Gill JS, Lee YC, Cardoso HM, Okpere BE, Bloom SR (1989) Increased neuropeptide Y concentrations in specific hypothalamic regions of the streptozocin-induced diabetic rats. Diabetes 38:321–327

    PubMed  CAS  Google Scholar 

  • Zucker I (1971) Light-dark rhythms in rat eating and drinking behavior. Physiol Behav 6:115–126

    PubMed  CAS  Google Scholar 

  • Zucker I, Stephan FK (1973) Light-dark rhythms in hamster eating, drinking and locomotor behaviors. Physiol Behav 11:239–250

    PubMed  CAS  Google Scholar 

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Kalra, S.P., Kalra, P.S. (1990). Neuropeptide Y: A Novel Peptidergic Signal for the Control of Feeding Behavior. In: Ganten, D., Pfaff, D. (eds) Behavioral Aspects of Neuroendocrinology. Current Topics in Neuroendocrinology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75837-9_8

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