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Corticotropin-Releasing Factor: Central Regulation of Autonomic Nervous and Visceral Function

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Behavioral Aspects of Neuroendocrinology

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 10))

Abstract

Behavioral and somatic responses to internal and external stimuli are attended and facilitated by appropriate alterations in endocrine and autonomic function. Transduction of sensory information into concurrent and complementary behavioral, hormonal, and visceral outputs is a primary function of the central nervous system (CNS). The neural circuitry and transmitters mediating specific components of adaptive whole-animal responses are understood in some detail whereas knowledge of CNS integrative mechanisms that coordinate differential patterns of physiological and behavioral activity is rudimentary at best. Owing to several unique features of peptide transmitters, recent attention has focused on their role in mediating CNS integrative functions.

This research was supported by grants from the NIH and NSF. L.A.F. is a Presidential Young Investigator of the National Science Foundation and is supported by an Established Investigator-ship from the American Heart Association.

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References

  • Berkenbosch F, van Oers J, del Rey A, Tilders F, Besedovsky H (1987) Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238: 524–526

    Article  PubMed  CAS  Google Scholar 

  • Beyer HS, Matta SG, Sharp BM (1988) Regulation of the messenger ribonuclei acid for corticotropin-releasing factor in the paraventricular nucleus and other brain sites of the rat. Endocrinology 123: 2117–2123

    Article  PubMed  CAS  Google Scholar 

  • Bloom FE, Battenberg ELF, Rivier J, Vale W (1982) Corticotropin releasing factor (CRF): immunoreactive neurones and fibers in rat hypothalamus. Regul Pept 4: 43–48

    Article  PubMed  CAS  Google Scholar 

  • Brown M (1986) Corticotropin releasing factor: central nervous system sites of action. Brain Res 399: 10–14

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Fisher LA (1983) Central nervous system effects of corticotropin releasing factor in the dog. Brain Res 280: 75–79

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Fisher LA (1984) Brain peptides as intercellular messengers. Implications for medicine. JAMA 251: 1310–1315

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Fisher LA (1985) Corticotropin-releasing factor: effects on the autonomic nervous system and visceral systems. Fed Proc 44: 243–248

    PubMed  CAS  Google Scholar 

  • Brown MR, Fisher LA (1986) Glucocorticoid suppression of the sympathetic nervous system and adrenal medulla. Life Sci 39: 1003–1012

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Gray TS (1988) Peptide injections into the amygdala of conscious rats: effects on blood pressure, heart rate and plasma catecholamines. Regul Pept 21: 95–106

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Fisher LA, Rivier J, Spiess J, Rivier C, Vale W (1982 a) Corticotropin-releasing factor: effects on the sympathetic nervous system and oxygen consumption. Life Sci 30:207–210

    Google Scholar 

  • Brown MR, Fisher LA, Spiess J, Rivier C, Rivier J, Vale W (1982b) Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology 111: 928–931

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Rivier C, Vale W (1984) Central nervous system regulation of adrenocorticotropin secretion: role of somatostatins. Endocrinology 114: 1546–1549

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Fisher LA, Webb V, Vale WW, Rivier JE (1985) Corticotropin-releasing factor: a physiologic regulator of adrenal epinephrine secretion. Brain Res 328: 355–357

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Gray TS, Fisher LA (1986) Corticotropin-releasing factor receptor antagonist: effects on the autonomic nervous system and cardiovascular function. Regul Pept 16: 321–329

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Hauger R, Fisher LA (1988) Autonomic and cardiovascular effects of corticotropinreleasing factor in the spontaneously hypertensive rat. Brain Res 441: 33–40

    Article  PubMed  CAS  Google Scholar 

  • Brown MR, Carver-Moore K, Gray TS, Rivier C (1989) Thyrotropin-releasing factor-induced adrenocorticotropin section is mediated by corticotropin-releasing factor. Endocrinology 125: 2558–2562

    Article  PubMed  CAS  Google Scholar 

  • Calogero AE, Gallucci WT, Chrousos GP, Gold PW (1988a) Interaction between GABAergic neurotransmission and rat hypothalamic corticotropin-releasing hormone secretion in vitro. Brain Res 463: 28–36

    Article  PubMed  CAS  Google Scholar 

  • Calogero AE, Gallucci WT, Gold PW, Chrousos GP (1988b) Multiple feedback regulatory loops upon rat hypothalamic corticotropin-releasing hormone secretion. Potential clinical implications. J Clin Invest 82: 767–774

    Article  PubMed  CAS  Google Scholar 

  • Calogero AE, Gallucci WT, Chrousos GP, Gold PW (1988c) Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro. J Clin Invest 82: 839–846

    Article  PubMed  CAS  Google Scholar 

  • Chappell PB, Smith MA, Kilts CD, Bissette G, Ritchie J, Anderson C, Nemeroff BC (1986) Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress. J Neurosci 6: 2908–2914

    PubMed  CAS  Google Scholar 

  • Ciriello J, Kline RL, Zhang T-X, Carverson MM (1984) Lesions of the paraventricular nucleus alter the development of spontaneous hypertension in the rat. Brain Res 310: 355–359

    Article  PubMed  CAS  Google Scholar 

  • Cunningham ET Jr, Sawchenko PE (1988) Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J. Comp Neurol 274: 60–74

    Article  PubMed  Google Scholar 

  • De Souza EB (1987) Corticotropin-releasing factor receptors in the rat central nervous system: characterization and regional distribution. J Neurosci 7: 88–100

    PubMed  Google Scholar 

  • De Souza EB, Insel TR, Perrin MH, Rivier J, Vale WW, Kuhar MJ (1985) Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study. J Neurosci 5: 3189–3203

    PubMed  Google Scholar 

  • Fisher LA (1988) Corticotropin-releasing factor: central nervous system effects on baroreflex control of heart rate. Life Sci 42: 2645–2649

    Article  PubMed  CAS  Google Scholar 

  • Fisher LA (1989a) Corticotropin-releasing factor: endocrine and autonomic integration of responses to stress. Trends Pharmacol Sci 10: 189–193

    Article  PubMed  CAS  Google Scholar 

  • Fisher LA (1989 b) Central autonomic modulation of cardiac baroreflex by corticotropin-releasing factor. Am J Physiol 256:H949–H955

    Google Scholar 

  • Fisher LA, Brown MR (1984) Corticotropin-releasing factor and angiotension II: comparison of CNS actions to influence neuroendocrine and cardiovascular function. Brain Res 296: 41–47

    Article  PubMed  CAS  Google Scholar 

  • Fisher LA, Overton JM (1988) Altered cardiovascular response to corticotropin-releasing factor in spontaneously hypertensive rats. Proc West Pharmacol Soc 31: 317–318

    PubMed  CAS  Google Scholar 

  • Fisher LA, Rivier J, Rivier C, Spiess J, Vale W, Brown MR (1982) Corticotropin-releasing factor (CRF): central effects on means arterial pressure and heart rate in rats. Endocrinology 110: 2222–2224

    Article  PubMed  CAS  Google Scholar 

  • Fisher LA, Jessen G, Brown MR (1983) Corticotropin-releasing factor (CRF): mechanism to elevate mean arterial pressure and heart rate. Regul Pept 5: 153–161

    Article  PubMed  CAS  Google Scholar 

  • Garrick NA, Hill JL, Szele FG, Tomai TP, Gold PW, Murphy DL (1987) Corticotropin-releasing factor: a marked circadian rhythm in primate cerebrospinal fluid peaks in the evening and is inversely related to the cortisol circadian rhythm. Endocrinology 121: 1329–1334

    Article  PubMed  CAS  Google Scholar 

  • Gibbs DM, Vale W (1983) Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood. Brain Res 280: 176–179

    Article  PubMed  CAS  Google Scholar 

  • Giuliano R, Ruggiero DA, Milner TA, Anwar M, Reis DJ (1988) Corticotropin-releasing factor: anatomical substrates of autonomic regulation. Soc Neurosci Abstr 14: 23

    Google Scholar 

  • Gray TS, Magnuson DJ (1987) Neuropeptide neuronal efferents from the bed nucleus of the stria terminalis and central amygdaloid nucleus to the dorsal vagal complex in the rat. J Comp Neurol 262: 365–374

    Article  PubMed  CAS  Google Scholar 

  • Grosskreutz CL, Brody MJ (1988) Regional hemodynamic responses to central administration of corticotropin-releasing factor ( CRF ). Brain Res 442: 363–367

    Article  PubMed  CAS  Google Scholar 

  • Haas DA, George SR (1988) Single or repeated mild stress increases synthesis and release of hypothalamic corticotropin-releasing factor. Brain Res 461: 230–237

    Article  PubMed  CAS  Google Scholar 

  • Hardwick AJ, Linton EA, Rothwell NJ (1989) Thermogenic effects of the antiglucocorticoid RU-486 in the rat: involvement of corticotropin-releasing factor and sympathetic activation of brown adipose tissue. Endocrinology 124: 1684–1688

    Article  PubMed  CAS  Google Scholar 

  • Hashimoto K, Hattori T, Murakami K, Suemaru S, Kawada Y, Kageyama J, Ota Z (1985) Reduction in brain immunoreactive corticotropin-releasing factor ( CRF) in spontaneously hypertensive rats. Life Sci 36: 643–647

    Article  PubMed  CAS  Google Scholar 

  • Insel TR, Aloi JA, Goldstein D, Wood JH, Jimerson DC (1984) Plasma cortisol and catecholamine responses to intracerebroventricular administration of CRF to rhesus monkeys. Life Sci 34: 1873–1878

    Article  PubMed  CAS  Google Scholar 

  • Irwin M, Hauger RL, Brown MR, Britton KT (1988) CRF activates autonomic nervous system and reduces natural killer cytotoxicity. Am J Physiol 255: R744 - R747

    PubMed  CAS  Google Scholar 

  • Jingami H, Matsukura S, Numa S, Imura H (1985) Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/ßlipotropin precursor mRNA in the pituitary in rats. Endocrinology 117: 1314–1320

    Article  PubMed  CAS  Google Scholar 

  • Kahn NH, Shelton SE, Kraemer GW, McKinney WT (1983) Corticotropin-releasing factor administered intraventricularly to rhesus monkeys. Peptides 4: 217–220

    Article  Google Scholar 

  • Kregel KC, Overton JM, Seals DR, Tipton CM, Fisher LA (1990) Cardiovascular responses to exercise in the rat: role of corticotropin-releasing factor. J App Physiol 68: 561–567

    CAS  Google Scholar 

  • Krukoff TL (1986) Segmental distribution of corticotropin-releasing factor-like and vasoactive intestinal peptide-like immunoreactivities in presumptive sympathetic preganglionic neurons of the cat. Brain Res 382: 153–157

    Article  PubMed  CAS  Google Scholar 

  • Kurosawa M, Sato A, Swenson RS, Takahashi Y (1986) Sympatho-adrenal medullary functions in response to intracerebroventricularly injected corticotropin-releasing factor in anesthetized rats. Brain Res 367: 250–257

    Article  PubMed  CAS  Google Scholar 

  • LeFeuvre RA, Rothwell NJ, Stock MJ (1987) Activation of brown adipose tissue in response to central injection of corticotropin releasing hormone in the rat. Neuropharmacology 16: 1217–1221

    Article  Google Scholar 

  • Lenz HJ (1989) Regulation of duodenal bicarbonate secretion during stress by corticotropin-releasing factor and ß-endorphin. Proc Natl Acad Sci USA 86: 1417–1420

    Article  PubMed  CAS  Google Scholar 

  • Lenz HJ, Fisher LA, Vale WW, Bronw MR (1985a) Corticotropin-releasing factor, sauvagine and urotensin-I: effects on blood flow. Am J Physiol 249: R85 - R90

    PubMed  CAS  Google Scholar 

  • Lenz HJ, Hester SE, Brown MR (1985b) Corticotropin-releasing factor. Mechanisms to inhibit gastric acid secretion in conscious dogs. J Clin Invest 75: 889–895

    Article  PubMed  CAS  Google Scholar 

  • Lenz HJ, Raedler A, Greten H, Vale WW, Rivier JE (1988) Stress-induced gastronintestinal secretory and motor responses in rats are mediated by endogeneous corticotropin-releasing factor. Gastroenterology 95: 1510–1517

    PubMed  CAS  Google Scholar 

  • Lightman SL, Young WC III (1988) Corticotropin-releasing factor, vasopressin and propiomelanocortin mRNA responses to stress and opiates in the rat. J Physiol (Lond) 403: 511–523

    CAS  Google Scholar 

  • Merchenthaler I, Hynes MA, Vigh S, Shally AV, Petrusz P (1983a) Immunocytochemical localiza- tion of corticotropin releasing factor ( CRF) in the rat spinal cord. Brain Res 275: 373–377

    Article  PubMed  CAS  Google Scholar 

  • Merchenthaler I, Vigh S, Petrusz P, Schally AV (1983b) The pareventriculo-infundibular corticotropin releasing factor ( CRF) pathway as revealed by immunocytochemistry in long-term hypophysectomized or adrenalectomized rats. Regul Pept 5: 295–305

    Article  PubMed  CAS  Google Scholar 

  • Moga MM, Gray TS (1985) Evidence for corticotropin-releasing factor, neurotensin, and somatostatin in the neural pathway from the central nucleus of the amygdala to the parabrachial nucleus. J Comp Neurol 241: 275–284

    Article  PubMed  CAS  Google Scholar 

  • Murakami K, Akana S, Dallman MF, Ganong WF (1989) Correlation between the stress-induced transient increase in corticotropin-releasing hormone content of the median eminence of the hypothalamus and adrenocorticotropic hormone secretion. Neuroendocrinology 49: 233–241

    Article  PubMed  CAS  Google Scholar 

  • Nakagami Y, Suda T, Yajima F, Ushiyama T, Tomori N, Sumitomo T, Demura H, Shizume K (1986) Effects of serotonin, cyproheptadine and reserpine on corticotropin-releasing factor release from the rat hypothalamus in vitro. Brain Res 386: 232–236

    Article  PubMed  CAS  Google Scholar 

  • Nicholson S, Lin J-H, Mahmound S, Campbell E, Gillham B, Jones M (1985) Diurnal variations in responsiveness of the hypothalamo-pituitary-adrenocortical axis of the rat. Neuroendocrinology 40: 217–224

    Article  PubMed  CAS  Google Scholar 

  • Nikolarakis KE, Almeida OFX, Herz A (1986) Stimulation of hypothalamic ß-endorphin and dynorphin release by corticotropin-releasing factor (in vitro). Brain Res 399: 152–155

    Article  PubMed  CAS  Google Scholar 

  • Olschowka JA, O’Donohue TL, Mueller GP, Jacobowitz DM (1982) The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain. Peptides 3: 995–1015

    Article  PubMed  CAS  Google Scholar 

  • Overton JM, Fisher LA (1989 a) Differentiated regional hemodynamic responses to peripheral and central administration of corticotropin-releasing factor. FASEB J 3:A1015

    Google Scholar 

  • Overton JM, Fisher LA (1989 b) Modulation of central nervous system actions of corticotropin-releasing factor by dnyorphin-related peptides. Brain Res 488:233–240

    Google Scholar 

  • Overton JM, Fisher LA (1989c) Central nervous system actions of corticotropin-releasing factor on cardiovascular function in the absence of locomotor activity. Regul Pept 25: 315–324

    Article  PubMed  CAS  Google Scholar 

  • Overton JM, Gorman G, Fisher LA (1989) Central nervous system effects of corticotropin-releasing factor on cardiac output. Soc Neurosci Abstr 15: 1181

    Google Scholar 

  • Overton JM, Davis-Gorman G, Fisher LA (1990) Central nervous system cardiovascular actions of CRF in sinoaortic-denervated rats. Am J Physiol 258: R596 - R601

    PubMed  CAS  Google Scholar 

  • Plotsky PM (1986) Opioid inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation of rats. Regul Pept 16: 235–242

    Article  PubMed  CAS  Google Scholar 

  • Plotsky PM (1987) Facilitation of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation after activation of catecholaminergic pathways or central norepinephrine injection. Endocrinology 121: 924–930

    Article  PubMed  CAS  Google Scholar 

  • Plotsky PM, Bruhn TO, Vale W (1984) Central modulation of immunoreactive corticotropin-releasing factor secretion by arginine vasopressin. Endocrinology 115: 1639–1641

    Article  PubMed  CAS  Google Scholar 

  • Plotsky PM, Otto S, Sutton S (1987) Neurotransmitter modulation of corticotropin releasing factor secretion into the hypophysial-portal circulation. Life Sci 41: 1311–1317

    Article  PubMed  CAS  Google Scholar 

  • Plotsky PM, Sutton SW, Bruhn TO, Ferguson AV (1988) Analysis of the role of angiotensin II in mediation of adrenocorticotropin secretion. Endocrinology 122: 538–545

    Article  PubMed  CAS  Google Scholar 

  • Redei E, Branch BJ, Gholami S, Lin EYR, Taylor AN (1988) Effects of ethanol on CRF release in vitro. Endocrinology 123: 2736–2743

    Article  PubMed  CAS  Google Scholar 

  • Rivier CL, Plotsky PM (1986) Mediation by corticotropin releasing factor ( CRF) of adenohypophysial hormone secretion. Annu Rev Physiol 48: 475–494

    Article  PubMed  CAS  Google Scholar 

  • Roth KA, Weber E, Barchas JD, Chang D, Chang J-K (1983) Immunoreactive dynorphin-(1 — 8) and corticotropin-releasing factor in subpopulation of hypothalamic neurons. Science 219: 189–191

    Article  PubMed  CAS  Google Scholar 

  • Sakanaka M, Shibasaki T, Lederis K (1986) Distribution and efferent projections of corticotropin-releasing factor-like immunoreactivity in the rat amygdaloid complex. Brain Res 382: 213–238

    Article  PubMed  CAS  Google Scholar 

  • Sapolsky R, Rivier C, Yamamoto G, Plotsky P, Vale W (1987) Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238: 522–524

    Article  PubMed  CAS  Google Scholar 

  • Saunders WS, Thornhill JA (1986) Pressor, tachycardic and behavioral excitatory responses in conscious rats following icy administration of ACTH and CRF are blocked by naloxone pretreatment. Peptides 7: 597–601

    Article  PubMed  CAS  Google Scholar 

  • Sawchenko PE (1987) Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvocellular neurosecretory neurons: anatomic, peptide and steroid specificity. J Neurosci 7: 1093–1106

    PubMed  CAS  Google Scholar 

  • Schipper J, Steinbusch HWM, Vermes I, Tilders FJH (1983) Mapping of CRF-immunoreactive nerve fibers in the medulla oblongata and spinal cord of the rat. Brain Res 267: 145–150

    Article  PubMed  CAS  Google Scholar 

  • Scoggins BA, Coghlan JP, Denton DA, Fei DW, Nelson MA, Tregear GW, Tresham J, Wang X (1984) Intracerebroventricular infusions of corticotropin releasing factor (CRF) and ACTH (1–24) raise blood pressure in sheep. Clin Exp Pharmacol Physiol 11: 365–368

    Article  PubMed  CAS  Google Scholar 

  • Silverman A-J, HouYu A, Chen W (1989) Corticotropin-releasing factor synapses within the paraventricular nucleus of the hypothalamus. Neuroendocrinology 49: 291–299

    Article  PubMed  CAS  Google Scholar 

  • Skofitsch G, Jacobowitz DM (1985) Distribution of corticotropin releasing factor-like immunoreactivity in the rat brain by immunohistochemistry and radioimmunoassay: comparison and characterization of ovine and rat/human CRF antisera. Peptides 6: 319–336

    Article  PubMed  CAS  Google Scholar 

  • Suda T, Yajima F, Tomori N, Demura H, Shizume K (1985) In vitro study of immunoreactive corticotropin-releasing factor release from the rat hypothalamus. Life Sci 37: 1499–1505

    Article  PubMed  CAS  Google Scholar 

  • Suda T, Yajima F, Tomori N, Sumitomo T, Nakagami Y, Ushiyama T, Demura H, Shizume K (1986) Inhibitory effect of adrenocorticotropin on corticotropin-releasing factor release from rat hypothalamus in vitro. Endocrinology 118: 459–461

    Article  PubMed  CAS  Google Scholar 

  • Suda T, Yajima F, Tomori N, Sumitomo T, Nakagami Y, Ushiyama T, Demura H, Shizume K (1987a) Stimulatory effect of acetylcholine on immunoreactive corticotropin-releasing factor release from the rat hypothalamus in vitro. Life Sci 40: 673–677

    Article  PubMed  CAS  Google Scholar 

  • Suda T, Yajima F, Tomori N, Sumitomo T, Nakagami Y, Ushiyama T, Demura H, Shizume K (1987b) Inhibitory effect of norepinephrine on immunoreactive corticotropin-releasing factor release from the rat hypothalamus in vitro. Life Sci 40: 1645–1649

    Article  PubMed  CAS  Google Scholar 

  • Suemaru S, Hashimoto K, Hattori T, Inoue H, Kageyama J, Ota Z (1986) Starvation-induced changes in rat brain corticotropin-releasing factor ( CRF) and pituitary-adrenocortical response. Life Sci 39: 1161–1166

    Article  PubMed  CAS  Google Scholar 

  • Swanson LW, Sawchenko PE, Rivier J, Vale WW (1983) Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 36: 165–186

    Article  PubMed  CAS  Google Scholar 

  • Szemeredi K, Bagdy G, Stull R, Calogero AE, Kopin IJ, Goldstein DS (1988) Sympathoadrenomedullary inhibition by chronic glucocorticoid treatment in conscious rats. Endocrinology 123: 2585–2590

    Article  PubMed  CAS  Google Scholar 

  • Tache Y, Goto Y, Gunion MW, Vale W, Rivier J, Brown M (1983) Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor. Science 222: 935–937

    Article  PubMed  CAS  Google Scholar 

  • Takao T, Hashimoto K, Ota Z (1988) Effect of atrial natriuretic peptide on acetylcholine-induced release of corticotropin-releasing factor from rat hypothalamus in vitro. Life Sci 42: 1199–1203

    Article  PubMed  CAS  Google Scholar 

  • Tsagarakis S, Holly JMP, Rees LH, Besser GM, Grossman A (1988) Acetylcholine and norepinephrine stimulate the release of corticotropin-releasing factor-41 from the rat hypothalamus in vitro. Endocrinology 123: 1962–1969

    Article  PubMed  CAS  Google Scholar 

  • Tsagarakis S, Navara P, Ress LH, Besser M, Grossman A (1989a) Morphine directly modulates the release of stimulated corticotropin-releasing factor-41 from rat hypothalamus in vitro. Endocrinology 124: 2330–2335

    Article  PubMed  CAS  Google Scholar 

  • Tsagarakis S, Gillies G, Rees LH, Besser M, Grossman A (1989b) Interleukin-1 directly stimulates the release of corticotropin releasing factor from rat hypothalamus. Neuroendocrinology 49:98–101

    Article  PubMed  CAS  Google Scholar 

  • Valentino RJ, Wehby RG (1988) Corticotropin-releasing factor: evidence for a neurotransmitter role in the locus ceruleus during hemodynamic stress. Neuroendocrinology 48: 674–677

    Article  PubMed  CAS  Google Scholar 

  • Widmaier EP, Lim AT, Vale W (1989) Secretion of corticotropin-releasing factor from cultured rat hypothalamic cells: effects of catecholamines. Endocrinology 124: 583–590

    Article  PubMed  CAS  Google Scholar 

  • Williams CL, Peterson JM, Villar RG, Burks TF (1987) Corticotropin-releasing factor directly mediates colonic responses to stress. Am J Physiol 253: G582 - G586

    PubMed  CAS  Google Scholar 

  • Yajima F, Suda T, Tomori N, Sumitomo T, Nakagami Y, Ushiyama T, Demura H, Shizume K (1986) Effects of opioid peptides on immunoreactive corticotropin-releasing factor release from the rat hypothalamus in vitro. Life Sci 39: 181–186

    Article  PubMed  CAS  Google Scholar 

  • Young WS III, Walker LC, Powever RE, De Souza EB, Price DL (1986) Corticotropin-releasing factor mRNA is expressed in the inferior olives of rodents and primates. Mol Brain Res 1: 189–192

    Article  CAS  Google Scholar 

  • Zhang T-X, Ciriello J (1985) Effect of paraventricular nucleus lesions on arterial pressure and heart rate after aortic baroreceptor denervation in the rat. Brain Res 341: 101–109

    Article  PubMed  CAS  Google Scholar 

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Fisher, L.A., Brown, M.R. (1990). Corticotropin-Releasing Factor: Central Regulation of Autonomic Nervous and Visceral Function. In: Ganten, D., Pfaff, D. (eds) Behavioral Aspects of Neuroendocrinology. Current Topics in Neuroendocrinology, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75837-9_2

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