Intravenous Administration of Nitrates
The first decade, when arrhythmias were effectively detected and treated, but little could be offered to treat hemodynamic deterioration.
The second decade, when intravenous nitrates, together with the modern sympathomimetic amines, provided a therapeutic tool for acute hemodynamic deterioration.
The third period, which has just begun, is the era of interventional cardiology. It has created new indications for intravenous nitrates as adjuncts to percutaneous transluminal coronary angioplasty and thrombolysis.