Abstract
Thermotolerance, the acquisition of a transiently increased resistance to heat induced by exposure to elevated temperature was first observed in mammalian cells subjected to fractionated hyperthermia in the treatment of cancer (Gerner and Schneider 1975; Henle and Leeper 1976). The increased resistance is marked; a preconditioning heat treatment can result in increased survival following severe heat treatment in the order of 104 to 105. This phenomenon is distinct from a clonal selection of resistant cells, as often seen with drug resistance, since it is noninheritable and can be induced by non-lethal preconditioning treatments. Thermotolerance appears to be a universal phenomenon, being observed in all organisms tested (reviewed in Lindquist and Craig 1988; Subjeck and Shyy 1986). The expression of thermotolerance is also seen at the level of the whole organism and occurs under natural conditions as well as following laboratory manipulations (e.g., Easton et al. 1987). Despite its universal nature, little is known of the mechanisms which lead to the enhanced survival of thermotolerant cells.
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Black, A.R., Subjeck, J.R. (1990). Mechanisms of Stress-Induced Thermo- and Chemotolerances. In: Schlesinger, M.J., Santoro, M.G., Garaci, E. (eds) Stress Proteins. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75815-7_9
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DOI: https://doi.org/10.1007/978-3-642-75815-7_9
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