Cytotoxicity Tests in the Biological Evaluation of Medical Devices
Since the early sixties mammalian and human cell cultures have been used as sensitive tool in the biological evaluation of medical and dental materials and devices. The three main areas of interest for the application of cell culture tests are:
Cytotoxicity tests are frequently used in the development, preclinical testing and quality assurance and are now subject to international standards. Based on the experience derived from testing more than 1000 medical and dental devices over a period of nine years some general remarks about cytotoxicity testing and examples of cytotoxicity test protocols are given.
mutagenicity tests, and
cell models for studying the interaction between device surface and surrounding tissue.
KeywordsPrimary Cell Culture Cytotoxicity Test Dental Material Biological Endpoint Optical Absorption Measurement
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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