Morphological and Functional Studies on Implanted Diffusion Membranes

  • U. Siebers
  • T. Zekorn
  • R. G. Bretzel
  • R. Sturm
  • H. Planck
  • M. Renardy
  • J. Trauter
  • P. Zschocke
  • K. Federlin
Conference paper

Abstract

Immunoisolated transplantation of islets of Langerhans inside preformed membranes may be a suitable therapy of insulin dependent diabetes mellitus (1.2). In vitro, morphological and functional survival of islets inside the device similar to that of free floating islets has been demonstrated previously (3). Nevertheless, for a transplantation therapy, behaviour of the artificial membranes in vivo must be investigated. In this study foreign body reaction towards different membranes was examined histologically and insulin diffusibility of explanted membranes was determined.

Keywords

Paraffin Collagenase Polysulfone Polyetheretherketone 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • U. Siebers
    • 1
  • T. Zekorn
    • 1
  • R. G. Bretzel
    • 1
  • R. Sturm
    • 1
  • H. Planck
    • 2
  • M. Renardy
    • 2
  • J. Trauter
    • 2
  • P. Zschocke
    • 2
  • K. Federlin
    • 1
  1. 1.Med.Klinik III der UniversitätGiessenGermany
  2. 2.ITV DenkendorfDenkendorfGermany

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