In Vitro Evaluation of the Effects of Macrophages and Synthetic Materials on the Fibroblast Proliferation and Collagen Synthesis

  • Jeong OK Lim
  • C. C. Chu
  • Max Appel

Abstract

The essential role of macrophages in the biological defense system has been well illustrated in many studies using foreign materials of either biological or synthetic nature.1 – 5 The presence of synthetic foreign materials whether because of necessity like modern surgical devices for the reconstruction of injured or diseased tissues/organs (e.g., vascular grafts, surgical mesh fabrics, artificial knee joint, etc.), or because of incidences like silica asbestos particles, eventually lead to a chronic inflammatory response followed by fibrous capsule formation around the synthetic foreign materials. A recent study of the ultra-structure of large accumulated cells immediately adjacent to synthetic foreign materials (i.e., a biodegradable wound closure material) indicated that macrophages played a major role in the phagocytosis of wound debris, and subsequent degradation, invasion, and phagocytosis of the synthetic foreign material.6

Keywords

Dust Polyethylene Rubber Prostaglandin Glucocorticoid 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Jeong OK Lim
    • 1
  • C. C. Chu
    • 1
  • Max Appel
    • 1
  1. 1.Department of Textiles & Apparel, Martha Van Rensselaer HallCornell UniversityIthacaUSA

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