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Bioartificial Endocrine Pancreas

Prerequisites and Current Status
  • Konrad Federlin
  • Tobias Zekorn
Conference paper

Abstract

Diabetes mellitus has an incidence of 2–4% in the population of Western Europe. 20 – 25% of patients either require insulin from the beginning (type-1-diabetes) or after years of treatment with insulin secretion stimulating drugs (secundary insulin-dependent type-2-diabetes). Although the introduction of insulin treatment remarkebly prolonged life expectancy, many patients develop severe late complications during the course of the disease. Diabetes is the most common reason for blindness and endstage renal failure leading to dialysis. Patients often develop macro- and microangiopathy and neuropathy during the course of the disease macro- and microangiopathy and neuropathy. This process can only be inhibited by an intensified insulin treatment. Successful islet transplantation would be the optimal treatment as insulin producing tissue would be replaced. Availibility of islets and immunological problems led to the idea of islet transplantation inside semipermeable artificial membranes i.e. the bioartificial pancreas (BAP). Different implantable devices are described and evaluated in this paper (BAP connected with blood circulation; macro- and microencapsulation). An introduction to problems of biocompatibility, diffusion conditions, islet survival and immuno isolation is presented together with an attempt to define required characteristics of membranes.

Keywords

Hollow Fiber Insulin Treatment Endstage Renal Failure Islet Transplantation Stimulate Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Konrad Federlin
    • 1
  • Tobias Zekorn
    • 1
  1. 1.Medizinische Klinik III und PoliklinikJustus Liebig-UniversitätGiessenWest-Germany

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