Abstract
Pregnancy, labor and delivery are potentially stressful states for the mother and fetus. Therefore, various researchers have measured β-endorphin in the peripheral plasma of women (a) during pregnancy, in labor, and after delivery; (b) in labor without and with epidural anesthesia; and (c) prior to and after induction of general or regional anesthesia for cesarian section. There have been also determinations of β-endorphin in the umbilical arterial and venous blood of newborns following spontaneous or operative vaginal and abdominal delivery, without and with fetal distress. It is the objective of this paper to summarize the data of other groups and to discuss our own measurements of maternal and neonatal β-endorphin in the light of other publications.
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References
Abboud TK, Noueihed R, Khoo SS, Hoffman DI, Varakian L, Henriksen E Goebelsmann U (1983a) Effects of induction of general and regional anesthesia for cesarean section on maternal plasma β-endorphin levels. Am J Obstet Gynecol 146: 927–930
Abboud TK, Sarkis F, Hung II, Khoo SS, Varakian L, Henriksen E, Noueihed R, Goebelsmann U (1983b) Effects of epidural anesthesia during labor on maternal plasma beta beta-en-dorphin levels. Anesthesiology 59: 1–5
Allen JR, Coor DM, Kendall JW, McGilvra R (1973) Maternal-fetal ACTH relationship in man. J Clin Endocrinol Metab 37: 230–234
Chernick V (1981) Endorphins and ventilatory control. N Engl J Med 304: 1227–1228
Csontos K, Rust M, Höllt V, Mahr W, Kromer W, Teschemacher HJ (1979) Elevated plasma β-endorphin levels in pregnant women and their neonates. Life Sci 25: 835–844
Davidson S, Gil-Ad I, Rogovin H, Laron Z, Reisner SH (1987) Cardiorespiratory depression and plasma β-endorphin levels in low-birth-weight infants during the first day of life. Am J Dis Child 41: 145–148
Distler W, Schwenzer T, Umbach G, Graf M (1988) β-Endorphin bei Frühgeburten und reifen Neugeborenen nach vaginaler und abdominaler Entbindung. Geburtshilfe Frauenheilkd 48: 140–142
Facchinetti F, Bagnoli F, Bracci R, Genazzani AR (1982) Plasma opioids in the first hours of life. Pediat Res 16: 95–98
Fraioli F, Genazzani AR (1980) Human placental β-endorphin. Gynecol Obstet Invest 11: 37–44
Genazzani AR, Facchinetti I, Parrini D (1981) β-Lipotropin and β-endorphin plasma levels during pregnancy. Clin Endocrinol (Oxf) 14: 409–418
Goebelsmann U, Abboud TK, Hoffman DI, Hung TT (1984) Beta- endorphin in pregnancy. Eur J Obstet Gynecol Reprod Biol 17: 77–89
Goland RS, Wardlaw SL, Stark RI, Frantz AG (1981) Human plasma β-endorphin during pregnancy, labor and delivery. J Clin Endocrinol Metab 52: 74–78
Goodlin RC (1981) Naloxone and its possible relationship to fetal endorphin levels and fetal distress. Am J Obstet Gynecol 139: 16–19
Hoffman DI, Abboud TK, Haase HR, Hung TT, Goebelsmann U (1984) Plasma β-endorphin concentrations prior to and during pregnancy, in labor and after delivery. Am J Obstet Gynecol 150: 492–498
Krieger DT, Liotta AS, Li CH (1977) Human plasma immunoreactive β-lipotropin: correlation with basal and stimulated plasma ACTH concentration. Life Sci 21: 1771–1777
Liotta AS Krieger DT (1980) In vitro biosynthesis and comparative translational processing of immunoreactive precursor corticotropin/β-endorphin by human placental and pituitary cells. Endocrinology 106: 1504–1511
Lord JAH, Waterfield A, Hughes J, Kosterlitz HW (1976) Multiple opiate receptors. In: Kosterlitz HW (ed) Opiates and endogenous opioid peptides. North-Holland, Amsterdam p 275
Orlowski JP, Lonsdale D, Denko CW (1982) β-Endorphin levels in infant apnea syndrome: a preliminary communication. Cleve Clin Q 49: 87–92
Pflug AE, Halter JB (1981) Effect of spinal anesthesia on adrenergic tone and neuroendocrine response to surgical stress in humans. Anesthesiology 55: 120–126
Pohjavuori M, Rovamo L, Laatikainen T (1985) Plasma immunoreactive β-endorphin and Cortisol in the newborn infant after elective caesarean section and after spontaneous labour. Eur J Obstet Gynecol Reprod Biol 19: 67–74
Reid RL, Hoff JD, Yen SSC, Li CH (1981) Effects of endogenous β-endorphin on pituitary hormone secretion and its disappearance rate in normal subjects. J Clin Endocrinol Metab 52: 1179–1184
Rust M, Csontos K, Mahr W, HöTlt V, Zilker T, Hegemann M, Teschemacher H (1980) Zum Verhalten von β-Endorphin in der Perinatalperiode. Geburtshilfe Frauenheilkd 40:769–774
Shaaban MM, Hung TT, Hoffmann DI, Lobo RA, Goebelsmann U (1982) β-Endorphin and β-lipotropin concentration in umbilical cord blood. Am J Obstet Gynecol 144: 560–568
Thomas TA, Fletcher JE, Hill RG (1982) Influence of medication, pain and progress in labor on plasma β-endorphin like immunoreactivity. Br J Anaesth 54: 401–408
Wardlaw SL., Stark RI, Baxi L, Frantz AG (1979) Plasma β- endorphin and β-lipotropin in the human fetus at delivery: correlation with arterial pH and pO2. J Clin Endocrinol Metab 49: 888–891
Wilkes MM, Stewart RD, Bruni JF, Quigley ME, Yen SSC, Ling N, Chretien M (1980) A specific homologous radioimmunoassay for human β-endorphin: direct measurement in biological fluids. J Clin Endocrinol Metab 50: 309–315
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Distler, W. (1990). Human Plasma β-Endorphin Levels in Pregnant Women and in Newborns. In: Distler, W., Beck, L. (eds) Endorphins in Reproduction and Stress. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75797-6_7
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DOI: https://doi.org/10.1007/978-3-642-75797-6_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52736-7
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