Structure and Biosynthesis of Nerve Growth Factor

  • M. Fahnestock
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 165)


The first description of nerve growth factor (NGF) by Levi-Montalcini and Hamburger (1953) was of a factor from mouse sarcoma cells (S-180 and S-37) that elicited extensive growth of chick embryo neurons. Shortly thereafter, a serendipitous use of snake venom in the purification of this factor led Cohen to the discovery that NGF was present in moccasin snake venom as well (Cohen and Levi-Montalcini 1956). The finding that the mouse submaxillary gland — a homologue of snake venom glands — stores even larger quantities of NGF than does the snake venom gland (Cohen 1960) led to the extensive analyses of mouse salivary NGF that continue today.


Nerve Growth Factor Snake Venom High Molecular Weight Complex Nerve Growth Factor mRNA Nerve Growth Factor Protein 
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© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • M. Fahnestock
    • 1
  1. 1.Molecular Biology Department SRI InternationalMenlo ParkUSA

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