Measuring Symptoms in Helicobacter pylori-Associated Gastritis and Non-Ulcer Dyspepsia
Methodological issues in measuring symptoms of Helicobacter pylori-associated gastritis (HPAG) and non-ulcer dyspepsia (NUD) for use in clinical trials to date have not received sufficient attention. To avoid confusion both the term HPAG and NUD will be defined first. The term HPAG is reserved for patients who are symptomatic and in whom after upper gastrointestinal endoscopy a firm diagnosis of histologically proven H. pylori gastritis is established. NUD patients are those persons that have histological evidence neither of gastritis nor of H. pylori. It should be stressed that we are not talking about patients with active duodenal ulceration, although symptom relief in these patients is also an important outcome measurement in clinical trials.
KeywordsIrritable Bowel Syndrome Symptom Measurement Irritable Bowel Syndrome Symptom Urea Breath Test Important Outcome Measurement
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- 6.Talley NJ, McNeil D, Hayden A, Piper DW. Randomized, double blind, placebo controlled crossover trial of cimetidine and pirenzepine in non-ulcer dyspepsia. Gastroenterology 91:149–156Google Scholar