Pharmacokinetics of Bismuth Compounds in Patients with Gastritis and Ulcer Disease During Standard Treatment

  • R. Raedsch
  • I. Walter-Sack
  • E. Weber
  • J. Blessing
Conference paper

Abstract

Since Helicobacter pylori was identified as an important factor in the pathogenesis of gastritis and ulcer disease, bismuth compounds have been widely used in the treatment of these diseases. The bismuth compounds at present on the market comprise subcitrate, subsalicylate, nitrate, gallate, and aluminate salts. After oral ingestion of these preparations, bismuth is partly absorbed from the intestine. Encephalopathy has been reported as one of several side effects of bismuth therapy in patients using large doses of bismuth preparations. In these patients, bismuth concentrations exceeding 100 µg/1 have been measured. From these findings, the recommendations were derived that bismuth treatment should be stopped if bismuth levels rise above 100 µg/1 [1]. Recently, peak bismuth concentrations in plasma exceeding 100 µg/1 have been reported in patients and healthy subjects after oral ingestion of standard doses of tripotassium dicitratobismuthate [2,3]. In the present study, we investigated the pharmacokinetics of the widely used compound bismuth subsalicylate and compared it with bismuth subcitrate.

Keywords

Graphite Bismuth Gastritis 

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References

  1. 1.
    Bader JP (1987) The safety profile of De-Nol. Digestion 37 [Suppl 2]::53–59PubMedCrossRefGoogle Scholar
  2. 2.
    Gavey CJ, Szeto ML, Nwokolo CU, Sercombe J, Pounder RE (1989) Bismuth accumulates in the body during treatment with tripotassium dicitrato bismuthate. Aliment Pharmacol Therap 3::21–28CrossRefGoogle Scholar
  3. 3.
    Nwokolo CU, Gavey CJ, Smith JTL, Pounder RE (1989) The absorption of bismuth from oral doses of tripotassium dicitrato bismuthate. Aliment Pharmacol Therap 3::29–39CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • R. Raedsch
  • I. Walter-Sack
  • E. Weber
  • J. Blessing

There are no affiliations available

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