Abstract
Condylomata acuminata caused by human papillomavirus infection constitute one of the most common sexually transmitted diseases which is showing a worldwide increase of incidence [8, 10, 14]. Numerous therapeutic regimens are available such as conservative methods including application of podophyllin, fluorouracil, colchicine, or bleomycin solutions. The most widely employed surgical methods are electrocaustic resection of the warts, cryotherapy, and Neodym Yag or carbon dioxide laser therapy. Altogether these methods are not satisfying. The therapeutic procedures in most cases lead to a complete removal of the warts, but there is a high recurrence rate with all these methods. As Jensen [12] reported, the recurrence rate after 3 months is 43% after podophyllin application and 18% after electrocautery. Three months later more than 50% of the patients treated by electrocautery will again register the appearance of genital warts. Newer operative procedures such as laser resection may be easier to handle and lead to fewer side effects, but the rate of recurrence will be the same as after electrocaustic resection [15]. According to our observations in large (more than 7 mm diameter) and numerous (>20) warts and in warts which have been recalcitrant for more than 2 years the recurrence rate is higher still than mentioned in the study of Jensen [4, 15]. Thus, it is not uncommon for patients to consult their physician several times a year for more than 5 or even 10 years seeking relief for their recurring genital or perianal warts.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Creagan ET, Ahmann DL, Frytak S, Long HJ, Chang MN, Itri LM (1986) Phase II tials of recombinant leucocyte A interferon in disseminated malignant melanoma. Cancer Treat Rep 70: 619–626
De Villiers E-M, Wagner D, Schneider A, Wesch H, Miklaw H, Wahrendorf J, Papendick U, zur Hausen H (1987) Human papillomaviruses in women with and without abnormal cervical cytology. Lancet 11 (8561): 703–705
Douglas JM, Royers M, Judson FN (1986) The effect of asymptomatic infection with HTLV III on the response of anogenital warts to intralesional treatment with recombinant alpha-2 interferon. J Infect Dis 154 (2): 331–334
Eron LJ, Judson F, Tucker S, Prawer S, Mills J, Murphy K, Hickey M, Rogers M, Flanningan S, Hien N, Katz HI, Gottlieb A, Adams K, Burton P, Tanner D, Taylor E, Peets E (1986) Interferon therapy for condylomata acuminata. N Engl J Med 315 (17): 1059–1064
Erpenbach K, Derschum W, Wiese H, v. Vietsch H (1989) Results of the combined laser and adjuvant interferon alpha 2B therapy for patients with therapy resistant anogenital condylomata acuminata. International symposium of advances in diagnosis and therapy of genital papillomavirus infections, Hamburg, Feb 3–5, 1989 (abstracted)
Esposito R, Orlando G,Lazzarin A, Chianura Castagna A, Verani P, Noroni M (1986) Recombinant alpha interferon treatment of AIDS-related Kaposi sarcoma. J Interferon Res 6: 46
Gall SA, Hughes CE, Trofatter K (1985) Interferon for the therapy of condylomata acuminata. Am J Obstet Gynecol 153 (2): 157–163
Gissmann L, Gross G (1985) Association of human papilloma viruses with human genital tumors. Clin Invest Dermatol 3: 124–126
Gross G, de Villiers EM, Roussaki A, Papendick U, Schöpf E (1986) Successful treatment of condylomata acuminata and bowenoid papulosis with subcutaneous injections of low dose recombinant interferon-alpha. Arch Dermatol 122: 749–750
Gross G, Pfister H, Gissmann L, Hagedorn M (1982) Correlation between human papillomavirus ( HPV) type and histology of warts. J Invest Dermatol 78: 160–164
Hohenleutner U, Landthaler M, Braun-Falco O, Schmoeckel C, Hans D (1988) Condylomata acuminata gigantea; Behandlung mit dem CO2-Laser und Interferon. Dtsch Med Wochenschr 113: 985–987
Jensen SL (1985) Comparison of podophyllin application with simple surgical excision in clearance of perianal condylomata acuminate. Lancet 11: 1146–1148
Kirchner H (1984) Interferons. A group of multiple lymphokines Immunopathology 2: 347–374
Lowy DR, Androphy EJ (1987) Warts. In: Fitzpatric TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds) Dermatology in general Medicine, 3rd edn. McGraw-Hill, New York, pp 2355–2372
Duus BR, Philipsen T, Christensen JD, Lundvall F, Sondergaard J (1985) Refractory condylomata acuminata: a controlled clinical trial of carbon dioxide laser versus conventional surgical treatment. Genitourin Med 61: 59–61
Tiedemann KH, Ernst ThM (1988) Kombinationstherapie von rezidivierenden Condylomata acuminata mit Elektrokaustik und Alpha-2-Interferon. Aktuel Dermatol 14: 200–204
Trofatter KFJ, English PC, Hughes CE, Gall SA (1986) Human lymphoblastoid interferon in primary therapy of two children with condylomata acuminata. Obstet Gyneco167(1): 137–140
Vance JB, Bart BJ, Hansen RC, Reichman RC, Mcewen C, Hatch KD, Berman B, Tanner DJ (1986) Intralesional recombinant alpha-2 interferon for the treatment of patients with condylomata acuminata or verruca plantaris. Arch Dermatol 122: 272–277
Weck PhD, Debra A, Buddin MSN, Wisnant JK (1988) Interferons in the treatment of genital human papillomavirus infections. Am J Med 85 [Suppl 2a]: 159–164
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Tiedemann, KH. (1990). Adjuvant Interferon Treatment of Condylomata Acuminata. In: Gross, G., Jablonska, S., Pfister, H., Stegner, HE. (eds) Genital Papillomavirus Infections. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75723-5_32
Download citation
DOI: https://doi.org/10.1007/978-3-642-75723-5_32
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75725-9
Online ISBN: 978-3-642-75723-5
eBook Packages: Springer Book Archive