Immunology of Genital Papillomavirus Infections

  • S. Jablonska
  • S. Majewski
Conference paper


Anogenital carcinomas and benign anogenital warts are associated with specific types of human papillomaviruses (HPVs). HPV 16, 18, 31 and 33 are the most common HPVs associated with anogenital carcinomas and/or with cervical dysplasia (Durst et al. 1983; Ikenberg et al. 1983; Boshart et al. 1984; Beaudenon et al. 1986; zur Hausen 1987; Howley 1987; zur Hausen and Schneider 1987). Also the newly characterized HPVs 35 (Lorincz et al. 1987), 45 (Nagashfar et al. 1987), 51 (Nuovo et al. 1988) and 52 (Shimoda et al. 1988) have been found to be associated with intraepithelial neoplasia and invasive carcinoma of the cervix. In contrast, HPV 6 and 11 are associated, in general, with benign anogenital lesions, i.e. with condylomata acuminata and lowgrade cervical intraepithelial neoplasia (de Villiers et al. 1981; Gissmann et al. 1982, 1983). Some other newly characterized HPVs, 42 (Beaudenon et al. 1987) and 44 (Lorincz et al. 1989), can also be regarded as a low risk for the development of genital cancer. However, HPV 6 subtypes have been detected repeatedly in locally destructive anogenital verrucous carcinomas (Okagaki et al. 1984; Lehn et al. 1984; Boshart and zur Hausen 1986; Rando et al. 1986; Guillet et al. 1988; Kasher and Roman 1988). HPV 16 is also associated with bowenoid papulosis (Durst et al. 1983; Gross et al. 1985, 1986; Obalek et al. 1985, 1986), with histological features of Bowen’s atypia, usually regressing after several months or years of duration. However, in some cases of bowenoid papulosis malignant transformation may occur (Lloyd 1970; Bergeron et al. 1987).


Cervical Intraepithelial Neoplasia Genital Wart Verrucous Carcinoma Cervical Neoplasia Condyloma Acuminata 
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  • S. Jablonska
  • S. Majewski

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