Production of Hematopoietic and Immune System Growth Factors After Marrow Transplantation and Their Use in Enhancing Haematopoietic and Immune Reconstitution
A severe combined cellular and humoral immune deficiency is consistently seen after both autologous and allogeneic marrow transplantation in humans , One of the most striking defects is the slow and abnormal return of T lymphocyte numbers, resulting in a long-term deficiency of CD4-positive T cells and a normal or increased number of CD8-positive T cells. Not surprisingly, this results in defects of T cell function including lymphokine production. Lymphokines produced by activated T lymphocytes include growth factors for both the immune system and the hematopoietic system. B cell function is also seriously impaired with absent or minimal antibody production by B cells, both in vitro and in vivo.
KeywordsPeripheral Blood Mononuclear Cell Abnormal Return Phorbol Myristate Acetate Total Body Irradiation Phorbol Myristate Acetate
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