Advertisement

Mobilization of Stem Cells and Progenitors After Thiamphenicol-Induced Hematopoietic Stress

  • H. Goris
  • B. Bungart
  • M. Loeffler
  • B. Dontje
  • W. Nijhof

Abstract

The presence of immature hematopoietic cells (CFU-S, CFU-GM, BFU-E) in the peripheral blood during recovery from hematopoietic stress is thought to be an event accompanying the redistribution of hematopoiesis. The harvest of these cells from the peripheral blood appears to be a valuable method in (auto)grafting. Insight into the processes following hematopoietic stress may improve the applicability of circulating immature cells in the cure of hematopoietic failure [1–3].

Keywords

Cell Stage Erythroid Precursor Stem Cell Regulation Recovery Pattern Total Bone Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    To LB, Haylock DN, Kimber RJ, Juttner CA (1984) High levels of circulating hematopoietic cells in very early remission from acute non-lymphoblastic leukemia and their collection and cryopreservation. Br J Haematol 58: 399–410PubMedCrossRefGoogle Scholar
  2. 2.
    Bell A J, Figes A, Oswer DG, Hamblin TJ (1987) Peripheral blood stem cell autografts in the treatment of lymphoid malignancies: initial experience in three patients. Br J Haematol 66: 63–68PubMedCrossRefGoogle Scholar
  3. 3.
    Kessinger A, Armitage J, Landmark JD, Smith DM, Weisenburger DD (1988) Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood 71: 723–727PubMedGoogle Scholar
  4. 4.
    Hara H, Ogawa M (1976) Erythropoietic precursors in mice with phenylhydrazine-induced anemia. Am J Hematol 1: 453–458PubMedCrossRefGoogle Scholar
  5. 5.
    Rencricca NJ, Rizzoli V, Howard D, Duffy P, Stohlman F (1970) Stem cell migration and proliferation during severe anemia. Blood 36: 764–771PubMedGoogle Scholar
  6. 6.
    Vos O, Buurman WA, Ploemacher RE (1972) Mobilization of haemopoietic stem cells ( CFU) into the peripheral blood of the mouse; effects of endotoxin and other compounds. Cell Tissue Kinet 5: 467–479PubMedGoogle Scholar
  7. 7.
    Monette FC, Morse BS, Howard D, Niskanen E, Stohlman F (1972) Hemopoietic stem cell proliferation and migration following Bordetella pertussis vaccine. Cell Tissue Kinet 5: 121–129PubMedGoogle Scholar
  8. 8.
    Kindler V, Thorens B, de Kossodo S, Allet B, Eliason JF, Thatcher D, Farber N, Vassalli P (1986) Stimulation of hematopoiesis in vivo by recombinant bacterial murine interleu- kin-3. Proc Natl Acad Sei USA 83: 1001–1005CrossRefGoogle Scholar
  9. 9.
    Tamura M, Hattorii K, Nomura H, Oheda M, Kubota N, Imazeka I, Ono M, Ueyema Y, Nagata S, Shirafugi N, Asano S (1987) Induction of neutrophilic granulocytosis in mice by administration of purified human native granulocyte colony-stimulating factor ( G-CSF ). Biochem Biophys Res Commun 142: 454–460PubMedCrossRefGoogle Scholar
  10. 10.
    Bungart B, Loeffler M, Goris H, Dontje B, Diehl V, Nijhof W (1990) Differential effects of recombinant human colony stimulating factor (rhG-CSF) on stem cells in marrow, spleen and peripheral blood in mice. Br J Haematol 76: 174–179PubMedCrossRefGoogle Scholar
  11. 11.
    Nijhof W, Wierenga PK (1982) The regeneration of stem cells after bone marrow depression induced by thiamphenicol. Exp Hematol 10: 36–43PubMedGoogle Scholar
  12. 12.
    Goris H, Loeffler M, Bungart B, Schmitz S, Nijhof W (1989) Hemopoiesis during thiamphenicol treatment: I. Stimulation of stem cells during eradication of intermediate cell stages. Exp Hematol 17: 957–961PubMedGoogle Scholar
  13. 13.
    Perper RJ, Zee TW, Mickelson MM (1968) Purification of lymphocytes and platelets by gradient centrifugation. J Lab Clin Med 72: 842–848PubMedGoogle Scholar
  14. 14.
    Till JE, McCulloch EA (1961) A direct measurement of radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14: 213–219PubMedCrossRefGoogle Scholar
  15. 15.
    Becker A J, McCulloch EA, Siminovitch L, Till JE (1965) The effect of differing demands for blood cell productin on DNA synthesis by hemopoietic colony-forming cells in mice. Blood 26: 296–308PubMedGoogle Scholar
  16. 16.
    Iscove NN, Sieber F (1975) Erythroid progenitors in mouse bone marrow detected by macroscopic colony formation in culture. Exp Hematol 3: 32–43PubMedGoogle Scholar
  17. 17.
    Loeffler M (1985) The role of the spleen in hemopoiesis. In: Wichmann HE, Loeffler M (eds) Mathematical modeling of cell proliferation: stem cell regulation in hemopoiesis, vol 2 CRC, Boca Raton, p 163Google Scholar
  18. 18.
    Wichmann HE, Loeffler M (1985) Structure of the model. In: Wichmann HE, Loeffler M (eds) Mathematical modeling of cell proliferation: stem cell regulation in hemopoiesis, Vol 1, CRC Boca Raton, p 55Google Scholar
  19. 19.
    Wright EG, Lord BI (1977) Regulation of CFU-S proliferation by locally produced endogenous factors. Biomedicine 27: 215–218PubMedGoogle Scholar
  20. 20.
    Ploemacher RE, van Soest PL, Vos O (1977) Kinetics of erythropoiesis in the liver induced in adult mice by Phenylhydrazine. Scand J Haematol 19: 424–434PubMedCrossRefGoogle Scholar
  21. 21.
    Pannacciulli IM, Massa GG, Saviane AG, Ghio RL, Bianchi GL, Bogliolo GV (1977) Effect of bleeding on in vivo and in vitro colony forming hemopoietic cells. Acta Hematol (Basel) 58: 27–32CrossRefGoogle Scholar
  22. 22.
    Seidel HJ, Kreja L (1985) Combination of irradiation and bleeding. In: Wichmann, Loeffler M (eds) Mathematical modeling of cell proliferation: stem cell regulation in hemopoiesis, vol 2. CRC, Boca Raton, p 43Google Scholar
  23. 23.
    Marsh JC, Boggs DR, Chervenick PA, Cartwright GE, Wintrobe MM (1968) Factors influencing hematopoietic spleen colony formation in irradiated mice. IV The effect of erythropoietic stimuli. J Cell Physiol 71: 65–75PubMedCrossRefGoogle Scholar
  24. 24.
    Moore MAS, Welte K, Gabrilove J, Souza LM (1987) Biological activities of recombinant human granulocyte colony stimulating factor (rhG-CSF) and tumor necrosis factor: in vivo and in vitro analysis. In: Neth R, Gallo RC, Greaves MF, Kabisch H (eds) Modern trends in human leukemia 7. Springer, Berlin Heidelberg New York, p210 (Hematology and blood transfusion, vol 31 )Google Scholar
  25. 25.
    Pojda Z, Molineux G, Dexter TM (1990) Hematopoietic effects of short-term in vivo treatment in mice with various doses of rhG-CSF. Exp Hematol 18: 27–31PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H. Goris
    • 1
  • B. Bungart
    • 2
  • M. Loeffler
    • 2
  • B. Dontje
    • 1
  • W. Nijhof
    • 1
  1. 1.Laboratory of Physiological ChemistryState UniversityGroningenThe Netherlands
  2. 2.Medical Clinic IUniversity of CologneKöln 41Germany

Personalised recommendations