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Peripheral Blood Stem Cell Autografts pp 209–240Cite as

Clinical Aspects of Autologous Blood Stem Cell Transplantations - Review of Indications

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Abstract

One of the main reasons to use blood rather than bone marrow-derived cells for autotransplants in malignancies is based on the hypothesis that they could be less likely contaminated by residual malignant cells and, consequently, that they might not carry the same risk of relapse as autologous bone marrow cells [1, 3]. This hypothesis originated from the fact that, in lymphohaematopoietic malignancies, the relapse often appears later in peripheral blood than in bone marrow. Some recent data from cytogenetic, genetic, immune and clonogenic assays from patients with malignancies prompt to moderate this assumption. Several variables can indeed influence the risk and the rate of neoplastic contamination. Probably the risk is different according to the type of disease and to its evolutive stage, to prior chemotherapy (in vivo “purging”), to the methods of mobilization and to the number of transplanted cells. Furthermore contribution to relapse of residual tumor cells in autologous grafts is ambiguous and remains to be determined for each individual disease.

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  1. P. R. Henon
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  1. Service d’Hématologie et Institut de Recherche en Hématologie, Transfusion Hospital du Hasenrain, 87 av. d’Altkirch, 68051, Mulhouse Cedex, France

    Eckart W. Wunder M.D. (Médecin attaché Prof. assoc., Head of Stem Cell Laboratory) & Philippe R. Henon M.D. (Chef de Service Prof. assoc., Director of Research) (Médecin attaché Prof. assoc., Head of Stem Cell Laboratory) &  (Chef de Service Prof. assoc., Director of Research)

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Henon, P.R. (1993). Clinical Aspects of Autologous Blood Stem Cell Transplantations - Review of Indications. In: Wunder, E.W., Henon, P.R. (eds) Peripheral Blood Stem Cell Autografts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75717-4_22

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