Abstract
In steady state, bone marrow and blood haematopoietic pools are in dynamic equilibrium, with 98% of all committed progenitor cells located in marrow and only 0.1% circulating in blood at any given time [7]. More immature cells, namely CD34 positive cells, represent a proportion of approximatively 1.5% among the total bone marrow mononuclear cells (MNC) [3], and ten times less in blood [1]. Consequently, it would be futile to hope achievement of successful blood derived stem cell transplantation by simple transfusion of whole blood or even of buffy coat.
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References
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© 1993 Springer-Verlag Berlin Heidelberg
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Henon, P.R., Wunder, E., Zingsem, J., Lepers, M., Siegert, W., Eckstein, R. (1993). Collection of Peripheral Blood Stem Cells Apheresis Monitoring and Procedure. In: Wunder, E.W., Henon, P.R. (eds) Peripheral Blood Stem Cell Autografts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75717-4_19
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DOI: https://doi.org/10.1007/978-3-642-75717-4_19
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