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Stem Cell Mobilization by Myelosuppressive Chemotherapy

  • L. B. To
  • C. A. Juttner

Abstract

Increased peripheral blood (PB) levels of granulocyte macrophage colony-froming units (CFU-GM) during haematopoietic recovery following cytotoxic-induced myelosuppression were first described in 1976 and 1979 [1, 2]. Richman et al. postulated that sufficient haematopoietic stem cells for autologous haematopoietic reconstitution could be collected by leukapheresis during such recovery. Further investigation of this alternative source of haematopoietic stem cells was initially limited, partly by the lack of technical expertise in stem cell apheresis and partly by the general view that PB stem cells (PBSC) were inferior to bone marrow stem cells in self-renewal and capacity to produce haematopoietic reconstitution (HR). This latter view resulted from murine studies [3–5] and from two reports of failed HR after PBSC infusion in humans [6, 7].

Keywords

Pluripotent Stem Cell Recovery Phase Acute Myeloid Leukaemia Peripheral Blood Stem Cell Acute Myeloid Leukaemia Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Richman CM, Weiner RS, Yankee RS (1976) Increase in circulating stem cells following chemotherapy in man. Blood 47: 1031–1039PubMedGoogle Scholar
  2. 2.
    Lohrmann HP, Schreml W, Fliedner TM, Heimpel H (1979) Reaction of human granulopoiesis to high-dose cyclophosphamide therapy. Blut 38: 9–16PubMedCrossRefGoogle Scholar
  3. 3.
    Micklem HS, Anderson N, Ross R (1975) Limited potential of circulating haemopoietic stem cells. Nature 256: 41–43PubMedCrossRefGoogle Scholar
  4. 4.
    Monette FC, Stockel JB (1980) Blood-borne stem cells are immunologically distinct from those in other haemopoietic tissues. Exp Hematol 8: 89–95PubMedGoogle Scholar
  5. 5.
    Chertkov JL, Gurevitch OA, Udalov G A (1982) Self-maintenance ability of circulating hemopoietic stem cells. Exp Hematol 10: 90–97PubMedGoogle Scholar
  6. 6.
    Hershko C, Ho WG, Gale RP, Cline MJ (1979) Cure of aplastic anaemia in paroxysmal nocturnal haemoglobulinuria by marrow transfusion from identical twin: failure of peripheral leucocyte transfusion to correct marrow aplasia. Lancet i: 945–947CrossRefGoogle Scholar
  7. 7.
    Abrams RA, Glaubiger D, Appelbaum FR, Deisseroth AB (1980) Result of attempted hematopoietic reconstitution using isologous peripheral blood mononuclear cells: a case report. Blood 56: 516–520PubMedGoogle Scholar
  8. 8.
    Storb R, Graham TC, Epstein RB, Sale GE, Thomas ED (1977) Demonstraton of hemopoietic stem cells in the peripheral blood of baboons by cross circulation. Blood 50: 537–542PubMedGoogle Scholar
  9. 9.
    Nothdurft W, Brush C, Fliedner TM, Ruber E (1977) Studies on the regeneration of the CFUc-population in blood and bone marrow of lethally irradiated dogs after autologous transfusion of cryopreserved mononuclear blood cells. Scand J Haematol 19: 470–481PubMedCrossRefGoogle Scholar
  10. 10.
    Abrams RA, McCormack K, Bowles C, Deisseroth AB (1981) Cyclophosphamide treatment expands the circulating haematopoietic stem cell pool in dogs. J Clin Invest 67: 1392–1399PubMedCrossRefGoogle Scholar
  11. 11.
    Korbling M, Burke P, Braine H, Elfenbein G, Santos GW, Kaizer H (1981) Successful engraftment of blood-derived normal hemopoietic stem cells in chronic myelogenous leukemia. Exp Hematol 9: 684–690PubMedGoogle Scholar
  12. 12.
    Goldman JM, Lu DP (1982) New approaches in chronic granulocytic leukemia - origin, prognosis and treatment. Semin Hematol 19: 241–256PubMedGoogle Scholar
  13. 13.
    McCarthy DM, Goldman JK (1984) Transfusion of circulating stem cells. CRC Crit 20: 1–24Google Scholar
  14. 14.
    To LB, Haylock DN, Kimber RJ, Juttner CA (1984) High levels of circulating haemopoietic stem cells in very early remission from acute non-lymphoblastic leukaemia and their collection and cryopreservation. Br J Haematol 58: 399–410PubMedCrossRefGoogle Scholar
  15. 15.
    Juttner CA, To LB, Haylock DN, Branford A, Kimber RJ (1985) Circulating autologous stem cells collected in very early remission from acute non-lymphoblastic leukaemia produce prompt but incomplete haemopoietic reconstitution after high dose melphalan and supralethal chemoradiotherapy. Br J Haematol 61: 739–746PubMedCrossRefGoogle Scholar
  16. 16.
    Korbling M, Dorken B, Ho AD, Pezzuto A, Hunstein W, Fliedner TM (1986) Autologous transplantation of blood-derived hemopoietic stem cells after myeloablative therapy in a patient with Burkett’s lymphoma. Blood 67: 629–632Google Scholar
  17. 17.
    Reiffers J, Bernard P, David B, Veszon G, Sarrat A, Marit G, Moulinier J, Broustet A (1986) Successful autologous transplantation with peripheral blood haemapoietic cells in a patient with acute leukaemia. Exp Hematol 14: 312–315PubMedGoogle Scholar
  18. 18.
    Bell AJ, Figes A, Oscier DG, Hamblin TJ (1986) Peripheral blood stem cell autografting. Lancet i: 1027CrossRefGoogle Scholar
  19. 19.
    Tilly H, Bastit D, Lucet JC, Esperou H, Monconduit M, Piguet H (1986) Haemopoietic reconstituion after autologous peripheral blood stem cell transplantation in acute leukaemia. Lancet ii: 154–155CrossRefGoogle Scholar
  20. 20.
    Mauch P, Ferrara J, Hellman S (1989) Stem cell self-renewal considerations in bone marrow transplantation. Bone Marrow Transplant 4: 601–607PubMedGoogle Scholar
  21. 21.
    Korbling M, Haas R, Knauf W, Holle R, Hunstein W (1990) Therapeutic efficacy of autologous blood stem cell transplantation (ABSCT): the role of cytotoxic/cytokine stem cell mobilization. Bone Marrow Transplant 5: 39–40PubMedGoogle Scholar
  22. 22.
    Brito-Babapulle F, Bowcock SJ, Marcus RE, Apperly J, Th’ng KH, Dowding C, Rassool F, Guo A-P, Catovsky D, Galton DAG, McCarthy D, Goldman JM (1989) Autografting for patients with chronic myeloid leukaemia in chronic phase: peripheral blood stem cells may have a finite capacity for maintaining haemopoiesis. Br J Haematol 73: 76PubMedCrossRefGoogle Scholar
  23. 23.
    Kessinger A, Armitage JO, Landmark JD, Weisenburger DD (1986) Reconstitution of human hematopoietic function with autologous cryopreserved circulating stem cells. Exp Hematol 14: 192–196PubMedGoogle Scholar
  24. 24.
    Kessinger A, Armitage JO, Landmark JD, Smith DM, Weisenburger DD (1988) Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood 71: 723–727PubMedGoogle Scholar
  25. 25.
    Kessinger A, Armitage JO, Smith DM, Landmark JD, Bierman PJ, Weisenburger DD (1989) High-dose therapy and autologous peripheral blood stem cell transplantation for patients with lymphoma. Blood 74: 1260–1265PubMedGoogle Scholar
  26. 26.
    Arlin ZA, Fried J, Clarkson BD (1978) Therapeutic role of cell kinetics in acute leukaemia. Clin Haematol 7: 339–362PubMedGoogle Scholar
  27. 27.
    To LB, Russell J, Moore S, Juttner CA (1987) Residual leukaemia cannot be detected in very early remission peripheral blood stem cell collections in acute non-lymphoblastic leukaemia. Leuk Res 4: 327–330CrossRefGoogle Scholar
  28. 28.
    Langlands K, Craig JIO, Parker AC, Anthony RS (1990) Molecular determination of minimal residual disease in peripheral blood stem cell harvests. Bone Marrow Transplant 5: 64–65PubMedGoogle Scholar
  29. 29.
    Sharp JG, Kessinger MA, DeBoer J, Mann S, Weisenburger DD (1989) Occult tumor cells in peripheral blood stem cell and bone marrow harvests of candidates for autologous transplantation. Exp Hematol 17: 650Google Scholar
  30. 30.
    Sieff CA (1990) Biology and clinical aspects of the hematopoietic growth factors. Annu Rev Med 41: 483–496PubMedCrossRefGoogle Scholar
  31. 31.
    Appelbaum FR (1989) The clinical use of hematopoietic growth factors. Semin Hematol 26: 7PubMedGoogle Scholar
  32. 32.
    Bell AJ, Oscier DG, Figes A, Hambin TJ (1987) Use of circulating stem cells to accelerate myeloid recovery after autologous bone marrow transplantation. Br J Haematol 67: 252–253PubMedCrossRefGoogle Scholar
  33. 33.
    To LB, Sheppard KM, Haylock DN, Dyson PG, Charles P, Thorp D, Dale BM, Dart GW, Roberts MM, Sage RE, Juttner CA (1990) Single high doses of cyclophosphamide enable the collection of high numbers of haemopoietic stem cells from the peripheral blood. Exp Hematol 18: 442–447PubMedGoogle Scholar
  34. 34.
    Broxmeyer HE, Jacobsen N, Kurland J, Mendelsohn N, Moore MAS (1978) In vitro suppression of normal granulocytic stem cells by inhibitory activity derived from human leukaemia cells. J Natl Cancer Inst 60: 497–511PubMedGoogle Scholar
  35. 35.
    Reiffers J, Bernard PH, Marit G, et al. (1986) Collection of blood-derived hemopoietic stem cells and applications for autologous transplantation. Bone Marrow Transplant 1: 371–372Google Scholar
  36. 36.
    To LB, Haylock DN, Dyson PG, Thorp D, Roberts MM, Juttner CA (1990) An unusual pattern of hemopoietic reconstitution in patients with acute myeloid leukaemia trans-planted with autologous recovery phase peripheral blood. Bone Marrow Transplant 6: 109–114PubMedGoogle Scholar
  37. 37.
    Lemischka IR, Raulet DH, Mulligan RC (1986) Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 45: 917–927PubMedCrossRefGoogle Scholar
  38. 38.
    Jones RJ, Celano P, Sharkis S, Sensenbrenner LL (1989) Two phases of engraftment established by serial bone marrow transplantation in mice. Blood 73: 397–401PubMedGoogle Scholar
  39. 39.
    Reiffers J, Leverger G, Marit G, Castaigne S, Tilley H, et al. (1988) Haematopoietic reconstitution after autologous blood stem cell transplantation. In: Gale RP, Champlin RE (eds) Bone marrow transplantation, current controversies, proceedings of Sandoz- UCLA symposium. Liss, New YorkGoogle Scholar
  40. 40.
    To LB, Haylock DN, Thorp D, Dyson PG, Branford AL, Ho JQKH, Dart GW, Roberts MM, Horvath N, Bardy P, Russell JA, Millar JL, Kimber RJ, Juttner C (1989) The optimisation of collection of peripheral blood stem cells for autotransplantation in acute myeloid leukaemia. Bone Marrow Transplant 4: 41–47PubMedGoogle Scholar
  41. 41.
    Stiff PJ, Koester AR, Lanzotti VJ (1986) Autologous transplantation using peripheral blood stem cells. Exp Hematol 14: 311Google Scholar
  42. 42.
    Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH (1984) Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-la cells. J Immunol 133: 157–165PubMedGoogle Scholar
  43. 43.
    Andrews RG, Singer JW, Bernstein ID (1989) Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properteis. J Exp Med 169: 1721–1730PubMedCrossRefGoogle Scholar
  44. 44.
    Berenson RJ, Andrews RG, Bensinger WI, Kalamasz D, Knitter G, Buckner CD, Bernstein ID (1988) Antigen CD34+ marrow cells engraft lethally irradiated babbons. J Clin Invest 81: 951–955PubMedCrossRefGoogle Scholar
  45. 45.
    Bender JG, Unverzagt KL, Walker DE, Lee W, Van Epps DE, Smith DH, Stewart CC, To LB (1991) Identification and comparison of CD34 positive cells from normal peripheral blood and bone marrow using multicolor flow cytometry. Blood 77: 259–296Google Scholar
  46. 46.
    Siena S, Bregni M, Brando B, Ravagnani F, Bonadonna G, Gianni AM (1989) Circulation of CD34+ hematopoietic stem cells in the peripheral blood of high dose cyclophospha- mide-treated patients: enhancement by intravenous recombinant human granulocyte- macrophage colony-stimulating factor. Blood 74: 1905PubMedGoogle Scholar
  47. 47.
    Juttner CA, To LB, Haylock DN, Dyson PG, Bradstock KF, Dale BM, Enno A, Sage RE, Szer J, Toogood IRG (1990) Approaches to blood stem cell mobilisation: initial Australian clinical results. Bone Marrow Transplant 5: 22–24PubMedGoogle Scholar
  48. 48.
    Lasky LC, Smith JA, McCullogh J, Zanjani (1987) Three-hour collection of committed and multipotent hematopoietic progenitor cells by apheresis. Transfusion 27: 276–278Google Scholar
  49. 49.
    Gianni AM, Siena S, Bregni M, et al. (1989) Granulocyte-macrophage colony-stimulating factor to harvest circulating haematopoietic stem cells for autotransplantation. Lancet 2: 580–585PubMedCrossRefGoogle Scholar
  50. 50.
    Gianni AM, Bregni M, Siena S, et al. (1989) Rapid and complete hemopoietic reconstitution following combined transplantation of autologous blood and bone marrow cells: a changing role for high dose chemoradiotherapy. Hematol Oncol 7: 139–148PubMedCrossRefGoogle Scholar
  51. 51.
    Klein B, Zhang XG, Jourdan M, Bataille R (1989) GM-CSF synergizes with IL-6 in supporting proliferation of human myeloma cells. Blood 74: 749Google Scholar
  52. 52.
    Bell AJ, Williamson PJ, North J, Watts EJ, Stephens JR (1989) Circulating stem cell autografts in high risk myeloma. Br J Haematol 71: 162–163PubMedCrossRefGoogle Scholar
  53. 53.
    Henon PH, Beck G, Debecker A, Eisenmann JC, Lepers M, Kandel G (1988) Autograft using peripheral blood stem cells collected after high dose melphalan in high risk multiple myeloma. Br J Haematol 70: 254–255PubMedCrossRefGoogle Scholar
  54. 54.
    Fernand JP, Levy Y, Gerota J, Cosset JM, Benbunan MN, Castaigne S, Seligman M, Broustet JC (1988) Treatment of aggressive multiple myeloma by high dose chemoradio-therapy and autologous blood stem cell graft. Bone Marrow Transplant 3: 80Google Scholar
  55. 55.
    Watanabe T, Takaue Y, Kawano Y, Koyama T, Huq MAHM, Shimokawa T, Ninomiya T, Aga Y, Inai T, Hiño M, Takehara H, Komi N, Kuroda Y (1989) Peripheral blood stem cell autotransplantation in treatment of childhood cancer. Bone Marrow Transplant 4: 261–265PubMedGoogle Scholar
  56. 56.
    Bell A J, Figes A, Oscier DG, Hamblin TJ (1987) Peripheral blood stem cell autografts in the treatment of lymphoid malignancies: initial experience in three patients. Br J Haematol 66: 63–68PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • L. B. To
    • 1
  • C. A. Juttner
    • 1
  1. 1.Division of Haematology, Institute of Medical and Veterinary Science, and Clinical Haematology and Bone Marrow Transplantation UnitRoyal Adelaide HospitalAdelaideAustralia

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