Stem Cell Mobilization by Myelosuppressive Chemotherapy

  • L. B. To
  • C. A. Juttner


Increased peripheral blood (PB) levels of granulocyte macrophage colony-froming units (CFU-GM) during haematopoietic recovery following cytotoxic-induced myelosuppression were first described in 1976 and 1979 [1, 2]. Richman et al. postulated that sufficient haematopoietic stem cells for autologous haematopoietic reconstitution could be collected by leukapheresis during such recovery. Further investigation of this alternative source of haematopoietic stem cells was initially limited, partly by the lack of technical expertise in stem cell apheresis and partly by the general view that PB stem cells (PBSC) were inferior to bone marrow stem cells in self-renewal and capacity to produce haematopoietic reconstitution (HR). This latter view resulted from murine studies [3–5] and from two reports of failed HR after PBSC infusion in humans [6, 7].


Pluripotent Stem Cell Recovery Phase Acute Myeloid Leukaemia Peripheral Blood Stem Cell Acute Myeloid Leukaemia Patient 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • L. B. To
    • 1
  • C. A. Juttner
    • 1
  1. 1.Division of Haematology, Institute of Medical and Veterinary Science, and Clinical Haematology and Bone Marrow Transplantation UnitRoyal Adelaide HospitalAdelaideAustralia

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