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Theoretical and Practical Considerations on the Use of Recombinant Human GM-CSF in Transplantation

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Peripheral Blood Stem Cell Autografts
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Abstract

It is of interest to review the uses of recombinant human GM-CSF (rhGM-CSF) in bone marrow transplantation at a time when there is so much clinical investigation directed at this topic. Indeed, only a year or so ago this subject would have been found in a section of this book entitled “New Developments and Future Concepts”. Now, it is established procedure, but one requiring careful and detailed refinement.

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References

  1. Aglietta M, Piacibello W, Sanavio F, Stacchini A, Apra F, Schena M, Caligaris-Cappio F, Camino F, Mossetti C, Gavosto F (1989) Kinetics of human hemopoietic cells after in vivo administration of GM-CSF. J Clin Invest 83: 551–557

    Article  PubMed  CAS  Google Scholar 

  2. Antman KS, Griffen JD, Ellas A, Socinski M, Ryan L, Cannistra S, Oette D, Whitley M, Frei E, Schnipper LE (1988) Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med 319: 593–598

    Article  PubMed  CAS  Google Scholar 

  3. Biesma B, DeVries E, Willemse P, Sluiter W, Postmus P, Limburg P, Vellenga E, Stern A (1990) Efficacy and tolerability of recombinant human granulocyte-macrophage colony- stimulating factor in patients with chemotherapy related leukopenia and fever. Eur J Cancer 26 (9): 932–936

    Article  PubMed  CAS  Google Scholar 

  4. Blazar BR, Widmer MB, Soderling CCB, Gillis S, Vallera DA (1988) Enhanced survival but reduced engraftment in murine recipients of recombinant granulocyte/macrophage colony-stimulating factor following transplantation of T-cell-depleted histoincompatible bone marrow. Blood 72: 1148–1154

    PubMed  CAS  Google Scholar 

  5. Blazar BR, Kersey JH, McGlave PB, Valera DA, Lasky LC, Haake RJ, Bostrom B, Weisdor DR, Epstein C, Ramsay NKC (1989) In vivo administration of recombinant human granulocyte/macrophage colony-stimulating factor in acute lymphoblastic leukemia patients receiving purged autografts. Blood 73: 849–857

    PubMed  CAS  Google Scholar 

  6. Brandt SJ, Peters WP, Atwater SK, Kurtzberg J, Borowitz MJ, Jones RB, Shpall EJ, Bast RC, Gilbert CJ, Oette D (1988) Effect of recombinant human granulocyte- macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. N Engl J Med 318:869– 875

    Article  PubMed  CAS  Google Scholar 

  7. Champlin RE, Nimer SD, Ireland P, Oette DH, Golde DW (1989) Treatment of refractory aplastic anemia with recombinant human granulocyte-macrophage colony stimulating factor. Blood 73: 694–699

    PubMed  CAS  Google Scholar 

  8. Cosman D (1988) Colony-stimulating factors in vivo and in vitro. Immunol Today 9:97– 98

    Article  PubMed  CAS  Google Scholar 

  9. Devereux S, Linch DC, Campos-Costa D, Spittle MF, Jelliffe AM (1987) Transient leukopenia induced by granulocyte-macrophage colony-stimulating factor. Lancet 2: 1523–1524

    Article  PubMed  CAS  Google Scholar 

  10. Devereux S, Bull HA, Campos-Costa D, Salb R, Linch DC (1989) Granulocyte- macrophage colony stimulating factor induced changes in cellular adhesion molecule expression and adhesion to endothelium: in-vitro and in-vivo studies in man. Br J Haematol 71: 323–330

    Article  PubMed  CAS  Google Scholar 

  11. De Witte T, Gratwohl A, Van der Lely N, Bacigalupo A, Speck B, Schattenberg T, Nissen C, Gluckman E, Fibbe WE, Stern AC (1992) Recombinant human granulocyte- macrophage colony stimulating factor (GM-CSF) accelerates neutrophil and monocyte recovery after allogeneic T-cell depleted bone marrow transplantation. Blood 79:1359– 1365

    PubMed  Google Scholar 

  12. DiPersio JF, Billing P, Williams R, Gasson JC (1988) Human granulocyte-macrophage colony-stimulating factor and other cytokines prime human neutrophils for enhanced arachidonic acid release and leukotriene b4 synthesis. J Immunol 140: 4315–4322

    Google Scholar 

  13. Ganser A, Völkers B, Greher J, Ottmann OG, Walther F, Becher R, Bergmann L, Schulz G, Hoelzer D (1989) Recombinant human granulocyte-macrophage colony stimulating factor in patients with myelodysplastic syndromes - a phase I/II trial. Blood 73: 31–37

    PubMed  CAS  Google Scholar 

  14. Gerhartz HH, Stern AC, Schmetzer H, Wolf-Hornung B, Wilmanns B (1989a) Placebo- controlled double blind study of granulocyte/macrophage colony-stimulating factor in chemotherapy-induced leukopenia. Xth congress of International Society of Hematology ( European and African Div ). Jerusalem Sept 3–8

    Google Scholar 

  15. Gerhartz HH, Visani G, Delmer A et al. (1989b) Randomized phase II study with GM- CSF and low dose ARA-C in patients with “high risk” myelodysplastic syndromes (MDS). 31st annual meeting of the American Society of Hematology. Blood 74:119 a

    Google Scholar 

  16. Gianni AM, Bregni M, Stern AC, Siena S, Tarella C, Orazi A, Bonadonna G (1989a) Very rapid and complete hematopoietic reconstitution following combined transplantation of autologous bone marrow and GM-CSF-exposed stem cells. Bone Marrow Transplant 4: 78

    Google Scholar 

  17. Gianni AM, Bregni M, Stern AC, Bonadonna G, Siena S, Tarella C, Pileri A (1989) Granulocyte-macrophage colony-stimulating factor to harvest circulating hemopoietic stem cells for autotransplantation. Lancet i: 580–584

    Article  Google Scholar 

  18. Gianni AM, Bregni M, Siena S, Orazi A, Stern AC, Gandola L, Bonadonna G (1990) hrGM-CSF reduces hematologic toxicity and widens clinical applicability of high-dose cyclophosphamide treatment in breast cancer and non-Hodgkin’s lymphoma. J Clin Oncol 8: 111

    Google Scholar 

  19. Groopman JE, Mitsuyasu RT, DeLeo MJ, Oette DH, Golde DW (1987) Effect of recombinant human granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. N Engl J Med 317: 593–598

    Article  PubMed  CAS  Google Scholar 

  20. Gulati SC, Bennet CL (1992) Granulocyte-macrophage colony-stimulating factor ( GM- CSF) as adjunct therapy in relapsed Hodgkin disease. Ann Intern Med 116: 177–182

    PubMed  CAS  Google Scholar 

  21. Lieschke GJ, Mäher D, Cebón J, O’Connor M, Green M, Sheridan W, Boyd A, Railings M, Bonnern E, Metealf D, Burgess AW, McGratj K, Fox RM, Morstyn G (1989a) Effects of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy. Ann Intern Med 110: 357–364

    PubMed  CAS  Google Scholar 

  22. Lieschke GJ, Cebon J, Morstyn G (1989b) Characterization of the clinical effects after the first dose of bacterially synthesized recombinant human granulocyte-macrophage colony stimulating factor. Blood 74: 2634–2643

    PubMed  CAS  Google Scholar 

  23. Lopez AF, Williamson DJ, Gamble JR, Begley CG, Harlan JM, Klebanoff SJ, Waltersdorph A, Wong G, Clark SC, Vadas MA (1986) Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression and survival. J Clin Invest 78:1200– 1228

    Article  Google Scholar 

  24. Mayer P, Valent P, Schmidt G, Liehl E, Bettelheim P (1989) The in-vivo effects of recombinant human interleukin-3: demonstration of basophil differentiation factor, histamine-producing activity, and priming of GM-CSF-responsive progenitors in non- human primates. Blood 74: 613–621

    PubMed  CAS  Google Scholar 

  25. Metcalf D (1989) The molecular control of cell division, differentiation commitment and maturation in hemopoietic cells. Nature 339: 27–30

    Article  PubMed  CAS  Google Scholar 

  26. Monroy RL, Skelly RR, MacVittie RJ, Davis TA, Sauber JJ, Clark SC, Donahue RE, (1987) The effect of recombinant GM-CSF on the recovery of monkeys transplanted with autologous bone marrow. Blood 70: 1696–1699

    PubMed  CAS  Google Scholar 

  27. Nemunaitis J, Singer JW, Buckner CD, Hill R, Storb R, Thomas ED, Appelbaum FR (1988) Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies. Blood 72: 834–836

    PubMed  CAS  Google Scholar 

  28. Nienhuis AW, Donahue RE, Karlsson S, Clark SC, Agricola B, Antinoff N, Pierce JE, Turner P, Anderson WF, Nathan DG (1987) Recombinant human granulocyte-macrophage colony-stimulating factor ( GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. J Clin Invest 80: 573–577

    Article  PubMed  CAS  Google Scholar 

  29. Peters WP, Stuart A, Affronti ML, Kim CS, Coleman RE (1988) Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusing after autologous bone marrow transplantation in humans. Blood 72:1310–1315

    PubMed  CAS  Google Scholar 

  30. Piguete D (1990) Personal communication

    Google Scholar 

  31. Powles R, Smith C, Milan S, Treleaven J, Millar J, McElwain T, Gorden-Smith E, Millikenm S, Tiley C, (1990) Human recombinant GM-CSF in allogeneic bone-marrow transplantation for leukaemia: double-blind, placebo controlled trial. The Lancet 336: 1417–1420

    Article  CAS  Google Scholar 

  32. Rankin EM, Mill L, Arden-Jones M, Kaye SB (1991) Once-daily subcutaneous injection of recombinant granulocyte-macrophage colony-stimulating factor (rhGM-CSf) helps reduce chemotherapy-induced neutropenia: a double-blind, placebo-controlled study. Sumitted for publication

    Google Scholar 

  33. Siena S, Bregni M, Brando B, Ravagnani F, Bonadonna G, Gianni AM (1989) Circulation of CD34-hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide treated patients: enhancement by intravenous recombinant human granulocyte-macrophage colony-stimulating factor. Blood 74: 1905–1914

    PubMed  CAS  Google Scholar 

  34. Socinski MA, Elias A, Schnipper L, Cannistra SA, Antman KA, Griffin JD (1988) Granulocyte-macrophage colony stimulating factor expands the circulating hematopoietic progenitor cell compartment in man. Lancet i: 1194–1198

    Article  Google Scholar 

  35. Steward WP, Scarffe JH, Austin R, Bonnem E, Thatcher N, Morgenstern G, Crowther D (1989) Recombinant human granulocyte macrophage colony-stimulating factor (rhGM- CSF) given as daily short infusions — phase I dose-toxicity study. Br J Cancer 59:142–145

    Article  PubMed  CAS  Google Scholar 

  36. Stoter G, Punt CJA, Jansen RLH et al. (1989) GM-CSF is effective during repeated multiple cycles of myelosuppression chemotherapy. Proc Am Soc Clin Oncol 8: 737

    Google Scholar 

  37. Taylor K, Spitzer G, Jagannath S, Dicke K, Vincent M, Souza L (1988) rhG-CsF hastens granulocyte recovery in Hodgkin’s disease after high-dose chemotherapy and autologous bone marrow transplant ( ABMT ). Exp Hematol 16: 413

    Google Scholar 

  38. Vose JM, Bierman PJ, Kessinger A, Coccia P, Oldham FB, Epstein C, Armitage JO (1989) The use of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) for delayed engraftment following high dose therapy and autologous hematopoietic stem cell transplantation for lymphoid malignancies. Blood 74:283 a

    Google Scholar 

  39. Wing EJ, Magee DM, Whiteside TL, Kaplan SS, Shadduck RK (1989) Recombinant human granulocyte/macrophage colony-stimulating factor enhances monocyte cytotoxicity and secretion of tumor necrosis factor-a and interferon in cancer patients. Blood 73: 636–646

    PubMed  Google Scholar 

  40. Zimmerli W, Zarth A, Gratwohl A, Nissen C, Speck B (1989) Granulocyte-macrophage colony-stimulating factor for defects of bone marrow transplant patients. Lancet i: 494

    Article  Google Scholar 

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© 1993 Springer-Verlag Berlin Heidelberg

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Jones, T.C. (1993). Theoretical and Practical Considerations on the Use of Recombinant Human GM-CSF in Transplantation. In: Wunder, E.W., Henon, P.R. (eds) Peripheral Blood Stem Cell Autografts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75717-4_11

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  • DOI: https://doi.org/10.1007/978-3-642-75717-4_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75719-8

  • Online ISBN: 978-3-642-75717-4

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