Peripheral Blood Stem Cells: 1909 to the Nineties

  • D. M. McCarthy


Allogeneic bone marrow transplantation from a fully matched sibling donor is now the treatment of choice for many malignant and nonmalignant diseases. Since many patients do not have a suitable sibling donor and because grafting from either a mismatched family donor or from a fully matched unrelated donor at present carries considerable risk, the role of autotransplantation, especially for the treatment of haematological and other malignancies, has been explored. Useful results have been obtained with this approach particularly in acute myeloid leukaemia [79, 4], and phase 3 multicentre trials, which examine the effect of autografting in acute myeloid leukaemia patients in first complete remission, are in progress. The roles of autografting in Hodgkin’s [80, 15] and non-Hodgkin’s lymphoma [69, 61], multiple myeloma [6] and various non-haematological malignancies [81, 26, 82] are being actively investigated.


Peripheral Blood Stem Cell Paroxysmal Nocturnal Haemoglobinuria Chronic Myeloid Leukaemia Patient Autologous Bone Marrow Transplantation Acute Myeloblastic Leukaemia 
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  1. 1.
    Abrams RA, Glaubiger D, Appelbaum FR, Deisseroth AB (1980) Result of attempted haemopoietic reconstitution using autologous peripheral blood mononuclear cells: a case report. Blood 56 (3): 516–520PubMedGoogle Scholar
  2. 2.
    Abrams RA, Johnston-Early A, Kramer C, Minna JD, Cohen MH, Deisseroth AB (1981) Amplification of circulating granulocyte-monocyte stem cell numbers following chemo-therapy in patients with extensive small cell carcinoma of the lung. Cancer Res 41: 35–41PubMedGoogle Scholar
  3. 3.
    Adams JA, Barrett AJ, Beard J, McCarthy DM (1988) Primary polycythaemia, essential thrombocythaemia and myelofibrosis — three facets of a single disease process. Acta Haematol 79: 33–37PubMedCrossRefGoogle Scholar
  4. 4.
    Anderson CC, Goldstone AH, Linch DC, Jones HM, Franklin IM, Boughton BJ, Cawley JC, Richards JDM (1987) Autologous bone marrow transplantation for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia — a comparison. Bone Marrow Transplant 1: 271–279PubMedGoogle Scholar
  5. 5.
    Ash RC, Detrick RA, Zanjani ED (1981) Studies of human pluripotential hemopoietic stem cells ( CFU-GEMM) in vitro. Blood 58: 309–316PubMedGoogle Scholar
  6. 6.
    Barlogie B, Alexanian R, Dicke K, Zagors G, Spitzer G, Jagannath S, Horwitz L (1987) High dose chemotherapy and autologous bone marrow transplantation for resistant multiple myeloma. Blood 70: 869–872PubMedGoogle Scholar
  7. 7.
    Barr RD, Whang-Peng J, Perry S (1975) Haemopoietic cells in human peripheral blood. Science 190: 280–281CrossRefGoogle Scholar
  8. 8.
    Barrett AJ, Longhurst P, Sneath P, Watson JC (1978) Mobilisation of CFU-C by exercise and ACTH-induced stress in man Exp Hematol 6: 590–594PubMedGoogle Scholar
  9. 9.
    Bell AH, Figes A, Oscier DG, Hamblin TH (1986) Peripheral blood stem cell autografting. Lancet 1: 1027PubMedCrossRefGoogle Scholar
  10. 10.
    Bell AJ, Williamson PJ, North J, Watts EJ, Stephens JR (1989) Circulating stem cell autografts in high risk myeloma. Br J Haematol 71: 162–163PubMedCrossRefGoogle Scholar
  11. 11.
    Bernard PL, Reiffers J, Vezon G, Sarrat A, Marit G, David B, Broustet A (1985) Collection of circulating haemopoietic cells after chemotherapy in acute non-lymphocytic leukaemia. B J Haematol 61: 577–594CrossRefGoogle Scholar
  12. 12.
    Brecher G, Cronkite EP (1951) Postradiation parabiosis and survival in rats. Proc Soc Exp Biol Med 77: 292–294PubMedGoogle Scholar
  13. 13.
    Brito-Bapapulle F, Bowcock SJ, Marcus RE, Applerly J, Th’ng KH, Dowding C, Rassool F, Ai-Pu G, Catovsky D, Galton DAG, McCarthy DM, Goldman JM (1989) Autografting for chronic myeloid leukaemia in chronic phase; peripheral blood stem cells may have a finite capacity to maintain haemopoiesis. Br J Haematol 73: 76–89CrossRefGoogle Scholar
  14. 14.
    Burnett AK, Tansey P, Mills C, Alcorn MJ, Sheehan T, McDonald GA, Banham GA (1982) Haematological reconstitution following high dose supralethal chemotherapy/ radiotherapy using stored non-cryopreserved autologous bone marrow. Br J Haematol 54: 309–316CrossRefGoogle Scholar
  15. 15.
    Carella AM, Marmont AM (1988) Salvage treatment for advanced resistant Hodgkins lymphoma; the role of bone marrow transplantation. Haematologica 73: 93–99PubMedGoogle Scholar
  16. 16.
    Castaigne S, Calvo F, Douay L, Thomas F, Benbunan M, Gerota J, Degos L (1986) Successful haematopoietic reconstitution using autologous peripheral blood mono- nucleated cells in a patient with acute promyelocytic leukaemia. Br Haematol 63: 209–211CrossRefGoogle Scholar
  17. 17.
    Cavins JA, Scheer SC, Thomas ED, Ferrebee JW (1964) The recovery of lethally irradiated dogs given infusions of autologous leukocytes preserved at -80°C. Blood 23: 38–43PubMedGoogle Scholar
  18. 18.
    Chervenick PA, Boggs DR (1971) In vitro growth of granulocytic and mononuclear cell colonies from blood of normal individuals. Blood 37: 131–135PubMedGoogle Scholar
  19. 19.
    Clark J, Pati A, McCarthy D (1991) Successful cryopreservation of human bone marrow does not require a controlled rate freezer. Bone Marrow Transplantation 7: 121–125PubMedGoogle Scholar
  20. 20.
    Cline MJ, Golde DW (1977) Mobilisation of hematopoietic stem cells ( CFU-C) into the peripheral blood of man by endotoxin. Exp Hematol 5: 186PubMedGoogle Scholar
  21. 21.
    Dinsmore RE, Straus DS; Pollack MS, Garrett TJ, Young CW, Clarkson BD, Dupont B (1980) Fatal graft versus host disease following blood transfusion in Hodgkin’s disease documented by HLA typing. Blood 55: 831–834PubMedGoogle Scholar
  22. 22.
    Fauser AA, Messner HA (1978) Granuloerythopoietic colonies in human bone marrow, peripheral blood and cord blood. Blood 52: 1243PubMedGoogle Scholar
  23. 23.
    Fauser AA, Messner HA (1979) Identification of megakarg and macrophages in colonies of human bone marrow containing neutrophilic granulocytes and crythroblasts. Blood 53:1023-1028PubMedGoogle Scholar
  24. 24.
    Fliedner TM, Calvo W, Korbling M, Nothdurft W, Pflieger H, Ross W (1979) Collection storage and transfusion of blood stem cells for the treatment of haemopoietic failure. Blood Cells 5: 313–328PubMedGoogle Scholar
  25. 25.
    Fliedner TM, Korbling M, Arnold R, Grilli G, Haen M, Kreutzmann H, Pflieger H (1979) Collection and cryopreservation of mononuclear blood leucocytes and of CFU-GEMM. Exp Hematol 7 [Suppl 5]: 398–408PubMedGoogle Scholar
  26. 26.
    Frei III E, Antman K, Teicher B, Eder P, Schniffer L (1989) Bone marrow autotransplantation for solid tumours — prospects. J Clin Oncol 8 (4): 515–526Google Scholar
  27. 27.
    Freireich EJ, Levin RH, Whang J, Carbone PP, Bronson W, Morse EE (1964) The function and fate of transfused leucocytes from donors with chronic myelocytic leukaemia in leucopenic recipients. Ann NY Acad Sci 113: 1081–1089PubMedCrossRefGoogle Scholar
  28. 28.
    Ganser A, Hoelzer D (1985) Megakaryocytic differentiation capacity of human pluripo- tent bone marrow progenitor cells CFU-GEMM in vitro after cryopreservation. Scand J Haematol 35: 418–422PubMedCrossRefGoogle Scholar
  29. 29.
    Geissler K, Hinterberger W, Lechner K (1986) Increased ratio of granulocyte/macrophage progenitor cells (CFU-GM) to multilineage progenitor cells ( CFU-mix) in the peripheral blood from patients with acute nonlymphoblastic leukaemia in very early remission. Br J Haematol 62: 596–597PubMedCrossRefGoogle Scholar
  30. 30.
    Gianni AM, Siena S, Bregni M, Torella C, Stern AC, Pileri A, Bonadonna G (1989) Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation. Lancet 11: 580–585CrossRefGoogle Scholar
  31. 31.
    Goldman JM, Th’ng KH, Lowenthal RM (1974) In vitro colony forming cells and colony stimulating factor in chronic granulocytic leukaemia. Br J Cancer 30: 1–12PubMedCrossRefGoogle Scholar
  32. 32.
    Goldman JM (1980) Haemopoietic stem cell autografts for leukaemia. Blut 41: 71–79PubMedCrossRefGoogle Scholar
  33. 33.
    Goldman JM, Catovsky D, Goolden AWG, Johnson SA, Galton DAG (1981) Buffy coat autografts for patients with chronic granulocytic leukaemia in transformation. Blut 42: 149–155PubMedCrossRefGoogle Scholar
  34. 34.
    Goodman JW, Hodgson BS (1962) Evidence for stem cells in the peripheral blood of mice. Blood 19: 702–704PubMedGoogle Scholar
  35. 35.
    Haines MA, Goldman JM, Worsely AM, McCarthy DM, Wyatt SE, Dowding C, Kearney L, Th’ng KH, Wareham N, Pollock A, Galvin MC, Samson D, Geary CG, Catovsky D, Galton DAG (1984) Chemotherapy and autografting for chronic granulocytic leukaemia in transformation: probable prolongation of survival for some patients. Br J Haematol 58: 714–721CrossRefGoogle Scholar
  36. 36.
    Hathaway WE, Fulginiti VA, Pierce CW, Githens J, Pearlman DS, Muschenheim F, Kempe CH (1967) Graft versus host reaction following a single blood transfusion. JAMA 201: 1015PubMedCrossRefGoogle Scholar
  37. 37.
    Henon P, Beck G, Debecker A, Eisenmann JC, Lepers M, Kandel G (1988) Autograft using peripheral blood stem cells collected after high dose melphalan in high risk multiple myeloma. Br J Haematol 70: 254–255PubMedCrossRefGoogle Scholar
  38. 38.
    Hershko C,Gale RP, Ho WG, Cline MJ (1979) Cure of aplastic anaemia in paroxysmal nocturnal haemoglobinuria by marrow transfusion from identical twin: failure of peripheral leucocyte tansfusion to correct marrow aplasia. Lancet 11: 945–947Google Scholar
  39. 39.
    Jacobson LO, Marks EK, Robson M, Gaston E (1949) The effect of spleen protection on mortality following x-irradiation. J Lab Clin Med 34: 1538Google Scholar
  40. 40.
    Jacobson LO, Marks EK, Gaston EO, Robson MJ, Zirkle RE (1949) Role of the spleen in radiation injury. Proc Soc Exp Biol Med 70: 740PubMedGoogle Scholar
  41. 41.
    Juttner CA, To LB, Haylock DN, Branford A, Kimber RJ (1985) Circulating autologous stem cells collected in very early remission from acute non-lymphoblastic leukaemia produce prompt but incomplete haemopoietic reconstitution after high dose melphalan or supralethal radiotherapy. Br J Haematol 61: 739 - 745PubMedCrossRefGoogle Scholar
  42. 42.
    Juttner CA, To LB, Dyson P, Haylock DN, Branford A, Kimber RJ (1986) The peripheral blood CFU-MIX:CFU-GM ratio during very early remission from acute lymphoblastic leukaemia. Br J Haematol 62: 598–599PubMedCrossRefGoogle Scholar
  43. 43.
    Kessinger A, Armitage JO, Landmark JD, Smith DM, Weisenburger (1988) Autologous peripheral haematopoietic stem cell transplantation restores haematopoietic function following marrow ablative therapy. Blood 71: (3)723–727PubMedGoogle Scholar
  44. 44.
    Korbling M, Burke P, Braine H, Elfenbein G, Santos GW, Kaizer H (1981) Successful engraftment of blood-derived normal hemopoetic stem cells in chronic myelogenous leukaemia. Exp Hematol 9: 684–690PubMedGoogle Scholar
  45. 45.
    Korbling M, Dorken B, Ho AD, Pezzutto A, Hunstein W, Fliedner TM (1986) Autologous transplantation of blood derived haemopoietic stem cells after myeloablative therapy in a patient with Burkitt’s lymphoma. Blood 67 (2): 529–532PubMedGoogle Scholar
  46. 46.
    Lasky L, Ash R, Kersey JH, Zanjani ED, McCullough J (1982) Collection of pluripotential hemopoietic stem cells by cytapheresis. Blood 59: 822–827PubMedGoogle Scholar
  47. 47.
    Lewis JR, Trobaugh FE Jr (1964) The assay of the transplantation potential of fresh and stored bone marrow by two in vivo systems. Ann NY Acad Sei 114: 677CrossRefGoogle Scholar
  48. 48.
    Lohrman HP, Schreml W, Lang M, Betzier N, Fliedner TM, Heimpel H (1978) Changes of granulopoiesis during and after adjuvant chemotherapy of breast cancer. Br J Haematol 40: 369–81CrossRefGoogle Scholar
  49. 49.
    Lopez M, Pouillart P, Mortel O, Fechtenbaum J (1988) Reconstitution of hemopoietic function with autologous cryopreserved peripheral blood stem cells and marrow incubated in vitro with mafosfamide in 6 patients with solid tumors. Exp Hematol 16 [suppl]: 158Google Scholar
  50. 50.
    Malinin TI, Perry VP, Kerby CC, Dolan MF (1965) Peripheral leukocyte infusion into lethally irradiated guinea pigs. Blood 25: 693–702Google Scholar
  51. 51.
    Maximow WA (1909) Der Lymphozyt als gemeinsame Stammzelle der verschiedenen Blutelemente in der embryonalen Entwicklung und im postfetalen Leben der Säugetiere. In: Kreutzmann H, Fliedner TM (1979) Scand J Haematol 23: 360Google Scholar
  52. 52.
    McCredie K, Hersh EM, Freireich EJ (1971) Cells capable of colony formation in the peripheral blood of man. Science 171: 293–294PubMedCrossRefGoogle Scholar
  53. 53.
    McElwain TS, Medley DW, Gordon MY, Jarman M, Millar JL, Pritchard J (1979) High dose melphalan and non cryopreserved autologous bone marrow treatment of malignant melanoma and neuroblastoma. Exp Hematol 7 [suppl 5]: 76Google Scholar
  54. 54.
    Merwin RM (1959) Repopulation of haematopoietic tissues of X-irradiated mice by cells from leukemoid blood. Proc Soc Exp Biol Med 101: 9–11PubMedGoogle Scholar
  55. 55.
    Moore M, Williams AN, Metealf D (1973) In vitro colony formation by normal and leukaemic haematopoietic cells: characterisation of the colony forming cells. JNCI 50: 603–623PubMedGoogle Scholar
  56. 56.
    Morra L, Ponassi A, Parodi CB, Caristo G, Bruzzi G, Sacchetti C (1981) Mobilisation of colony forming cells ( CFU-U) into the peripheral blood of man by hydrocortisone. Biomed 35: 87Google Scholar
  57. 57.
    Netzl B, Brehm G, Grosse-Wilde H, Ruppert WS, Thierfelder S (1974) Enrichment of large quantités of granulopoietic progenitor cells from human peripheral blood. Exp Hematol 2: 275Google Scholar
  58. 58.
    Nothdurft W, Fliedner TM, Calvo W, Flad H-D, Miget R, Korbling M, Krumbacher-von- Loringhofen K, Ross WM, Schnappauf H-P, Steinbach L (1978) CFU-U populations in blood and bone marrow of dogs after lethal irradiation and allogeneic transfusion with cryopreserved blood mononuclear cells. Scand J Haematol 21: 115–130PubMedCrossRefGoogle Scholar
  59. 59.
    Ogawa M, Brush OC, O’Dell RF, Hara M, McEachern MD (1977) Circulating erythopoietic precursors assessed in culture: characteristics in normal men and patients with haemoglobinopathies. Blood 50: 1081–1092PubMedGoogle Scholar
  60. 60.
    Parkman R, Mosier D, Umansky I, Cochran W, Carpenter CB, Rosen FS (1974) Graft versus host disease after intrauterine and exchange transfusions for hemolytic disease of the newborn. N Engl J Med 190: 359–363CrossRefGoogle Scholar
  61. 61.
    Philip T, Armitage JO, Spitzer G, Chauvin F, Jagannath S, Cahn JY, Colombat P, Goldstone AH, Gorin NC, Flesh M, Laporte JP, Maraninchi D, Pico J, Bosley A, Anderson C, Schots R, Biron P, Cabamillas F, Dicke K (1987) High dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate grade or high grade non-Hodgkin’s lymphoma. N Engl J Med 316: 1493–1498PubMedCrossRefGoogle Scholar
  62. 62.
    Popp R (1960) Erythrocyte repopulation in x-irradiated recipients of nucleated peripheral blood cells of normal mice. Proc Soc Exp Biol Med 104: 7214Google Scholar
  63. 63.
    Reid CDL, Kirk A, Muir J, Chanarin I (1989) The recovery of circulating progenitor cells after chemotherapy in AML and ALL and its relation to the rate of bone marrow regeneration after aplasia. Br J Haematol 72: 21–27PubMedCrossRefGoogle Scholar
  64. 64.
    Reiffers J, Bernard P, David B, Vegos G, Sarrat A, Marit G, Moulinier J, Broustet A (1986) Successful autologous transplantation with peripheral blood haemopoietic cells in a patient with acute leukaemia. Exp Hematol 14: 312–315PubMedGoogle Scholar
  65. 65.
    Reiffers J, Marit G, Bernard P, David B, Sarrat A, Chevaleyre J, Vezon G, Broustet A (1987) Haemopoietic reconsittution after peripheral blood stem cell autografting. Bone Marrow Transplant 2 [suppl 1]: 71Google Scholar
  66. 66.
    Rich KC, Richman CM, Mejias E, Daddona P (1980) Immunoreconstitution by peripheral blood leucocytes in adenosine deaminase-defîcient severe combined immunodeficiency. J Clin Invest 66: 389–395PubMedCrossRefGoogle Scholar
  67. 67.
    Richman CM, Weiner RS, Yankee RA (1976) Increase in circulating stem cells following chemotherapy in man. Blood 47: 1031–1039PubMedGoogle Scholar
  68. 68.
    Ross DD, Poliak A, Akman SA, Bachur NR (1980) Diurnal variation of circulating human myeloid progenitor cells. Exp Hematol 8: 954PubMedGoogle Scholar
  69. 69.
    Schouten HC, Bierman PJ, Vaughan WP, Kessinger A, Vose JM, Weisenburger DD, Armitage JO (1989) Autologous bone marrow transplantation in follicular non Hodgkin’s lymphoma before and after histologic transformation. Blood 74 (7): 2579–2584PubMedGoogle Scholar
  70. 70.
    Socinski MA, Cannistra SA, Elias A, Antman KH, Schniffer L, Griffen JD (1988) Granulocytic macrophage colony stimulating factor expands the circulating haemopoietic progenitor cells compartment in man. Lancet 1: 1194–1198PubMedCrossRefGoogle Scholar
  71. 71.
    Stiff PJ, Murgo AJ, Wittes RE, De Risi MF, Clarkson BD (1983) Quantification of the peripheral blood colony forming unit-culture rose following chemotherapy: could leucocytaphereses replace bone marrow for autologous transplantation? Transfusion 23: 500–503PubMedCrossRefGoogle Scholar
  72. 72.
    Stiff PJ, Murgo AJ, Zaroulis CG, De Risi MF, Clarkson BD (1983) Unfractionated human bone marrow cell cryopreservation using dimethyl sulfoxide and hydroxyethyl starch. Cryobiology 20: 17–24PubMedCrossRefGoogle Scholar
  73. 73.
    Stiff PJ, Koester AR, Weidner MK, Dvorak K, Fisher RI (1987) Autologous bone marrow transplantation using unfractionated cells cryopreserved in dimethyl sulfoxide and hydroxyethyl/starch without controlled rate freezing. Blood 70: 974–978PubMedGoogle Scholar
  74. 74.
    Storb R, Prentice R, Thomas ED (1977) Letter. N Engl J Med 297: 58CrossRefGoogle Scholar
  75. 75.
    Storb R, Graham TC, Epstein RB, Sale GE, Thomas ED (1977a) Demonstration of hemopoietic stem cells in the peripheral blood of baboons by cross circulation. Blood 50: 537–542PubMedGoogle Scholar
  76. 76.
    Takaue Y, Watanabe T, Kawano Y, Koyama T, Abe T, Suzue T, Satoh J, Shimokawa T, Ninomiya T, Kosaka M, Shimizu E, Ogura T, Kuroda Y (1989) Isolation and storage of peripheral blood hematopoietic stem cells for autotransplantation into children with cancer. Blood 74 (4): 1245–1251PubMedGoogle Scholar
  77. 77.
    Tilly H, Bastit D, Lucet J-C, Esperou H, Monconduit M, Piguet M (1986) Haemopoietic reconstitution after autologous peripheral blood stem cell transplantation in acute leukaemia. Lancet II: 154–155CrossRefGoogle Scholar
  78. 78.
    To LB, Haylock DN, Kimber J, Juttner CA (1984) High levels of circulating haemopoietic stem cells in very early remission from acute non-lymphoblastic leukaemia and their collection and cryopreservation. Br J Haematol 58: 399–410PubMedCrossRefGoogle Scholar
  79. 79.
    Tutschka PJ, Copelan EA, Klein JP (1987) Bone marrow transplantation for leukaemia following a new busulfan and cyclophosphamide regime. Blood 70: 1382–1388PubMedGoogle Scholar
  80. 80.
    Williams SF, Bitran JD (1989) The role of high-dose therapy and autologous bone marrow reinfusion in the treatment of Hodgkin’s disease. Hematol Clin North Am 3 (2): 319–330Google Scholar
  81. 81.
    Williams SF, Nick R, Desser R, Golick J, Beschorner J, Bitran JD (1989) High dose consolidation therapy with autologous stem cell rescue in stage IV breast cancer. J Clin Oncol 7 (12): 1824–1830PubMedGoogle Scholar
  82. 82.
    Wolff SN, Herzig RH, Fay JW, LeMaistre CF, Frei-Lahr D, Lowder J, Bolwell B, Giannono L, Herzig GP (1989) High-dose thiotepa with autologous bone marrow transplantation for metastatic malignant melanoma: results of phase I and II studies of the North American Bone Marrow Transplant Group. J Clin Oncol 7 (2): 245–249PubMedGoogle Scholar
  83. 83.
    Zander AR, Gray KN, Hester JP, Johnston DA, Spitzer G, Raulston GL, McCredie KB, Jardine JH, Wu J, Gleiser C, Cundiff J, Dicke KA (1984) Rescue by peripheral blood mononuclear cells in dogs from bone marrow failure after total body irradiation. Transfusion 24 (l): 42–45PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • D. M. McCarthy
    • 1
  1. 1.Haematology DepartmentCharing Cross and Westminster Medical SchoolLondonUK

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