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Imaging, Cerebral Topography and Alzheimer’s Disease pp 41–51Cite as

Distribution of Neurochemical Deficits in Alzheimer’s Disease

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Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Summary

Cortical inhibitory neurotransmitters, neuropeptides, dopamine and probably noradrenaline are probably either not selectively or not critically affected in Alzheimer’s disease. It is, however, highly likely that shrinkage or loss of corticocortical pyramidal neurones is a key change. This change appears to be circumscribed and clinically relevant and to involve neurotransmitter glutamate. The putative pathogenic role of glutamate is briefly discussed.

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Authors
  1. D. M. Bowen
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  2. A. J. Cross
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  3. P. T. Francis
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  4. A. R. Green
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  5. S. L. Lowe
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  6. A. W. Procter
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  7. J. E. Steele
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  8. G. C. Stratmann
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Editor information

Editors and Affiliations

  1. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 20892, Bethesda, MD, USA

    Stanley I. Rapoport M.D.

  2. A.D.E.R.M.A., Faculté de Médecine, Université de Lille, 1, place de Verdun, F-59045, Lille Cédex, France

    Henri Petit M.D.  & Didier Leys M.D.  & 

  3. Fondation IPSEN pour la Recherche Thérapeutique, 30, rue Cambronne, F-75737, Paris Cédex, France

    Yves Christen Ph.D.

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© 1990 Springer-Verlag Berlin Heidelberg

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Bowen, D.M. et al. (1990). Distribution of Neurochemical Deficits in Alzheimer’s Disease. In: Rapoport, S.I., Petit, H., Leys, D., Christen, Y. (eds) Imaging, Cerebral Topography and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75690-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-75690-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75692-4

  • Online ISBN: 978-3-642-75690-0

  • eBook Packages: Springer Book Archive

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