Summary Comments on Presentations

  • S. I. Rapoport
Conference paper
Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)


When I became involved with Alzheimer’s disease about 10 years ago, I and others thought it to be a global dementia — showing global changes in neuropathology, cognition, and brain metabolism. In the meantime, however, we have discovered that it is a much more subtle disease, and that it deserves to be examined in terms of the topography of the anatomical, functional, and neurochemical systems that it selectively affects. In my introductory paper, I posed the hypothesis that association brain areas (neocortical assocation areas as well as nonneocortical, phylogenically older regions that are connected with association neocortical areas) are more vulnerable to Alzheimer’s disease than are other brain regions. This principle of selective regional vulnerability also applies, with different areas being affected, to Huntington’s disease, Parkinson’s disease, Pick’s disease, and several other neurodegenerative disorders.


Positron Emission Tomography Single Photon Emission Compute Tomography Alzheimer Patient Primary Progressive Aphasia Summary Comment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1990

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  • S. I. Rapoport

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