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Biological Dosimetry of Absorbed Radiation Dose: Considerations of Low-Level Radiations

  • M. S. Sasaki
  • Y. Ejima
  • S. Saigusa

Abstract

Chromosome aberration analysis in peripheral blood lymphocytes provides a valuable means for dose assessment in persons exposed to ionizing radiation. To date, several methods have been proposed for the chromosome-based dose assessment (IAEA 1986). However, in spite of the growing importance in the risk assessment, the dose-yield kinetics of chromosome aberrations and their implications for dose assessment are not well established in exposures to low-level radiation.

Keywords

International Atomic Energy Agency Chromosome Aberration Fluence Rate Relative Biological Effectiveness Fission Neutron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Booz J, Feinendegen LE (1988) A microdosimetric understanding of low-dose radiation effects. Int J Radiat Biol 53: 13–21CrossRefGoogle Scholar
  2. Buckton KE, Court Brown WM, Smith PG (1967) Lymphocyte survival in man treated with X-rays for ankylosing spondylitis. Nature 214: 470–473PubMedCrossRefGoogle Scholar
  3. Buckton KE, Langlands AO, Woodcock GE (1967b) Cytogenetic damage following Thorotrast administration. Int J Radiat Biol 12: 565–577CrossRefGoogle Scholar
  4. Edwards AA, Purrott RJ, Prosser JS, Lloyd DC (1980) The induction of chromosome aberrations in human lymphocytes by alpha-radiation. Int J Radiat Biol 38: 83–91CrossRefGoogle Scholar
  5. International Atomic Energy Agency (IAEA) (1986) Biological dosimetry: chromosomal aberration analysis for dose assessment. IAEA Technical Report Series No. 260Google Scholar
  6. Kemmer W, Muth H, Tranekjer F, Edelmann L (1971) Dose dependence of the chromosome aberration rate in Thorotrast patients. Biophysik 7: 342–351PubMedCrossRefGoogle Scholar
  7. Kemmer W, Steinsträsser A, Muth H (1979) Chromosome aberrations as a biological dosimeter in Thorotrast patients: dosimetric problems. Environ Res 18: 178–183PubMedCrossRefGoogle Scholar
  8. Lloyd DC, Edwards AA, (1983) Chromosome aberrations in human lymphocytes: effect of radiation quality, dose, and dose rate. In: Ishihara T, and Sasaki MS (eds) Radiation-induced chromosome damage in man. Liss, New York pp 23–49Google Scholar
  9. Norman A, Sasaki MS, Ottoman RE, Fingerhut AG (1965) Lymphocyte lifetime in women. Science 147: 745PubMedCrossRefGoogle Scholar
  10. Preston DL, McConney MR, Awa AA, Ohtaki K, Itoh M, Honda T (1988) Comparison of the dose- response relationships for chromosome aberration frequencies between the T65D and DS86 dosimetries. Radiation Effects Research Foundation Technical Report, RERF TR pp 7–88Google Scholar
  11. Roesch WC (ed) 1987 US-Japan Joint Reassessment of Atomic Bomb Radiation Dosimetry in Hiroshima and Nagasaki, vol 1. Radiation Effects Research Foundation, HiroshimaGoogle Scholar
  12. Rundo J (1955) Considerations of the limits of radiation dosage from Thorotrast. Br J Radiol 28: 615–619PubMedCrossRefGoogle Scholar
  13. Sasaki MS, Takatsuji T, Ejima Y, Kodama S, Kido C (1987) Chromosome aberration frequency and radiation dose to lymphocytes by alpha-particles from internal deposit of Thorotrast. Radiat Environ Biophy 26: 227–238CrossRefGoogle Scholar
  14. Savage JRK (1970) Site of radiation induced chromosome exchanges. Curr Top Radiat Res 6: 130–194Google Scholar
  15. Shimizu Y, Kato H, Schull WJ, Preston DL, Fujita S, Pierce DA (1987) Life span study report 11, part 1. Comparison of risk coefficients for site-specific cancer mortality based on the DS86 and T65D shielded kerma and organ doses. Radiation Effects Research Foundation Technical Report, RERF TR 12–87Google Scholar
  16. Wolff S, Azal V, Wiencke JK, Olivieri G, Michaeli A (1988) Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA. Int J Radiat Biol 53: 39–48CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. S. Sasaki
  • Y. Ejima
  • S. Saigusa
    • 1
  1. 1.Radiation Biology CenterKyoto UniversityYoshida-Konoecho, Sakyo-ku, Kyoto 606Japan

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