Drugs and Pulmonary Perfusion

  • B. E. Marshall
  • C. Marshall
Conference paper
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 215)


The relationship between flow and pressure in the pulmonary circulation is non-linear and because the flow is high and the pressure is low, subtile changes in pressure may reflect quite profound changes in vascular properties. Principal among these properties is vascular tone, which is a functional concept representing the net State of the vasculature after all of the forces, both active and passive, have interacted.


Oxygen Tension Pulmonary Artery Pressure Pulmonary Circulation Pulmonary Vessel Hypoxic Pulmonary Vasoconstriction 
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  1. 1.
    Zhuang, F.Y., Y.C. Fung, and R.T. Yen: Analysis of blood flow in cat’s lung with detailed anatomical and elasticity data. J. Appl. Physiol. 55: 1341–1348, 1983.PubMedGoogle Scholar
  2. 2.
    Marshall, B.E., and C. Marshall: A model for hypoxic constriction of the pulmonary circulation. J. Appl. Physiol. 64: 68–77, 1988.PubMedCrossRefGoogle Scholar
  3. 3.
    Mitzner W: Resistance of the pulmonary circulation. Clin. Chest. Med. 4: 127–137, 1983.PubMedGoogle Scholar
  4. 4.
    Fung Y.C., S.S. Sobin, H. Tremer, M.R.T. Yen and H.H. Ho: Patency and compliance of pulmonary veins when airway pressure exceeds blood pressure. J. Appl. Physiol. 54: 1538–1549, 1983.PubMedGoogle Scholar
  5. 5.
    West J.B.: Ventilation/blood flow and gas exchange, Ed 3. Philadelphia, F.A. Davis, 1982.Google Scholar
  6. 6.
    Cox, R.H.: Comparison of mechanical and chemical properties of extra and intralobar canine pulmonary arteries. Am. J. Physiol. 242 (Heart Circ. Physiol. 11): H245–H253, 1982.PubMedGoogle Scholar
  7. 7.
    Maloney, J.E., S.A. Rooholamini, and L. Wexler.: Pressure-diameter relations of small blood vessels in isolated dog lungs. Microvasc. Res. 2: 1–12, 1970.PubMedCrossRefGoogle Scholar
  8. 8.
    Fung, Y.C. and S.S. Sobin: Elasticity of the pulmonary alveolar sheet. Circ. Res. 30: 451–469, 1972.PubMedGoogle Scholar
  9. 9.
    Rodman, D.M., T. Yamaguchi, R.F. O’Brien, and I.F. McMurtry: Hypoxie contraction of isolated rat pulmonary artery. J. Pharmacol. Exper. Ther. 248: 952–959, 1989.Google Scholar
  10. 10.
    Madden, J.A., C.A. Dawson, and D.R. Härder: Hypoxia induced activation in small isolated pulmonary arteries from the cat. J. Appl. Physiol. 59: 113–118, 1985.PubMedGoogle Scholar
  11. 11.
    Murray, T.R., B.E. Marshall, and E.J. Macarak: Hypoxie vasoconstriction in cultured smooth muscle cells. Am. J. Resp. Cell Mol. Biol. In press, 1990.Google Scholar
  12. 12.
    Marshall, C., and B.E. Marshall: Site and sensitivity for Stimulation of hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 55: 711–716, 1983.PubMedGoogle Scholar
  13. 13.
    Marshall, B.E., C. Marshall, M. Magno, P. Lilagen: Bronchial oxygen tension influences pulmonary vascular resistance. Physiologist 32: 195, 1989.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • B. E. Marshall
  • C. Marshall

There are no affiliations available

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