Catecholamines and Pulmonary Perfusion
β-phenylethylamine can be viewed as the parent Compound of the sympathomimetic amines, consisting of a benzene ring and an ethylamine side chain. The structure permits substitutions to be made on the aromatic ring, the alpha- and β-carbon atoms, and the terminal amino group, to yield a great variety of Compounds with sympathomimetic activity. Norepinephrine, epinephrine, dopamine, dobutamine, dopexamine and isoproterenol have OH groups substituted in the 3 and 4 positions of the benzene ring. Since dihydroxybenzene is also known as catechol, sympathomimetic amines with these OH substitutions in the aromatic ring are termed catecholamines (fig 1).
KeywordsPulmonary Circulation Vasodilator Response Hypoxic Pulmonary Vasoconstriction Pulmonary Perfusion Blood Flow Distribution
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