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Role of Xanthine Oxidase-Derived Oxidants and Granulocytes in Ischemia/Reperfusion

  • Barbara J. Zimmerman
  • D. Neil Granger
Conference paper

Abstract

There is now a large body of experimental data which suggests that oxygen radicals mediate the microvascular and parenchymal cell damage observed during reperfusion of ischemic tissues. The information derived from several studies performed in our laboratory and by others have led us to construct a biochemical scheme to explain oxygen-dependent reperfusion injury (Fig. 1). The scheme predicts that xanthine oxidase-derived oxidants produced after reoxygenation of ischemic intestine play an important role in recruiting and activating circulating granulocytes, which ultimately mediate reperfusion-induced microvascular injury. Although the proposed mechanism may be applicable to several organ systems, the following discussion is largely confined to the small intestine (Granger, 1988).

Keywords

Xanthine Oxidase Leukocyte Adherence Intestinal Ischemia Microvascular Permeability Xanthine Oxidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin, Heidelberg 1990

Authors and Affiliations

  • Barbara J. Zimmerman
    • 1
  • D. Neil Granger
    • 1
  1. 1.Department of PhysiologyLouisiana State University Medical CenterShreveportUSA

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