Mg2+ in Neurotrauma: Its Role and Therapeutic Implications

  • Robert Vink
  • Tracy K. McIntosh
  • Alan I. Faden


In Western, developed countries such as the USA, UK, New Zealand, and Australia, injury to the brain or spinal cord results in more deaths in individuals under 44 years of age than all other causes of death (Selecki et al. 1980; Frankowski et al. 1985). As such it can be considered the primary killer of young people in these countries. Aside from the significant mortality and morbidity associated with central nervous system (CNS) injury, in financial terms the cost to the community for hospitalization and rehabilitation runs into billions of dollars per year. Recent developments suggest that much of the injury associated with CNS trauma can be prevented. While some of the tissue damage associated with the development of irreversible injury occurs at the time of injury, much of it is delayed, arising hours to days after the initial insult (Cooper 1985). Recognition of the factors that contribute to the development of irreversible injury permits development of “antifactors” that may attenuate or even prevent manifestation. This review will concentrate on one factor that has been receiving increasing attention in the study of neurotrauma: Mg2+.


Traumatic Brain Injury Spinal Cord Injury Excitatory Amino Acid Traumatic Spinal Cord Injury Opiate Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Adam WR, Craik DJ, Hall JG, Kneen MM, Wellard RM (1988) Problems in the assessment of magnesium depletion in the rat by in vivo 31P NMR. Magn Reson Med 7:300–310PubMedCrossRefGoogle Scholar
  2. Aikawa JK (1981) Magnesium: it’s biologic significance. CRC, Boca RatonGoogle Scholar
  3. Allen AR (1911) Surgery of experimental lesion equivalent to crush injury of fracture dislocation of spinal column. JAMA 57:878–880CrossRefGoogle Scholar
  4. Altura BM, Altura BT (1985 a) New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system. I: clinical aspects. Magnesium 4:226–244PubMedGoogle Scholar
  5. Altura BM, Altura BT (1985 b) New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system. II: experimental aspects. Magnesium 4:245–271PubMedGoogle Scholar
  6. Altura BM, Altura BT, Gebrewold A, Ising H, Gunther T (1984) Magnesium deficient diets and microcirculatory changes in situ. Science 223:1315–1317PubMedCrossRefGoogle Scholar
  7. Altura BT, Altura BM (1982) The role of magnesium in etiology of strokes and cerebrospasm. Magnesium 1:277–291Google Scholar
  8. Bakshi R, Faden AI (1990) Competitive and non-competitive NMDA antagonists limit dynorphinA-induced rat hindlimb paralysis. Brain Res 507:1–5PubMedCrossRefGoogle Scholar
  9. Bara M, Guiet-Bara A (1984) Potassium, magnesium and membranes. Magnesium 3:212–225Google Scholar
  10. Borchgrevink PC, Bergan AS, Bakoy OE, Jynge P (1989) Magnesium and reperfusion of ischemic rat heart as assessed by 31P-NMR. Am J Physiol 256:H195–H204PubMedGoogle Scholar
  11. Brooks KJ, Bachelard HS (1989) Changes in intracellular free magnesium during hypoglycemia and hypoxia in cerebral tissue as calculated from 31P-nuclear magnetic resonance spectra. J Neurochem 53:331–334PubMedCrossRefGoogle Scholar
  12. Bygrave FL (1978) Mitochondria and the control of intracellular calcium. Biol Rev 53:43–79PubMedCrossRefGoogle Scholar
  13. Caudle RM, Isaac L (1988) A novel interaction between dynorphin (1–13) and an n-methyl-D-aspartate site. Brain Res 443:329–332PubMedCrossRefGoogle Scholar
  14. Cavaliere F, Sciarra M, Crea MA, Rossi M, Proietti R (1985) Variazioni del magnesio sierico ed urinario in pazienti traumatizzati cranici. Recenti Prog Med 76:563–566PubMedGoogle Scholar
  15. Chaudry IH, Clemens MG, Baue AE (1986) The role of ATP-magnesium in ischemia and shock. Magnesium 5:211–220PubMedGoogle Scholar
  16. Choi D (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369–379PubMedGoogle Scholar
  17. Cittadini A, Bossi D, Wolf FI, Dani AM (1982) The role of the intracellular Ca/Mg ratio in bioenergetic reactions. In: Anghileri LJ, Tuffet-Anghileri AM (eds) The role of calcium in biological systems, vol 1. CRC, Boca Raton, pp 189–200Google Scholar
  18. Cooper PR (1985) Delayed brain injury: secondary insults. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 217–228Google Scholar
  19. Corkey BE, Duszynski J, Rich TL, Matschinsky B, Williamson JR (1986) Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria. J Biol Chem 261:2567–2574PubMedGoogle Scholar
  20. Demediuk P, Saunders RD, Clendenon NR, Means ED, Anderson DK, Horrocks LA (1985) Changes in lipid metabolism in traumatized spinal cord. Prog Brain Res 63:1–16Google Scholar
  21. DeSalles AF, Kontos HA, Becker DP, Yang MS, Ward JD, Moulton R, Gruemer HD, Lutz H, Maset AL, Jenkins L, Marmarou A, Muizelaar P (1986) Prognostic significance of ventricular CSF lactic acidosis in severe head injury. J Neurosurg 65:615–624PubMedCrossRefGoogle Scholar
  22. DeWitt DS, Kong DL, Lyeth BG, Jenkins LW, Hayes RL, Wooten ED, Prough DS (1988) Experimental traumatic brain injury elevates brain prostaglandin E2 and thromboxane B2 levels in rats. J Neurotrauma 4:303–313CrossRefGoogle Scholar
  23. Dixon CE, Lyeth BG, Povlishock JT (1987) A fluid percussion model of experimental brain injury in the rat. J Neurosurg 67:110–119PubMedCrossRefGoogle Scholar
  24. Ebel H, Günther T (1980) Magnesium metabolism: a review. J Clin Chem Clin Biochem 18:257–270PubMedGoogle Scholar
  25. Ellis EF, Wright KF, Wei EP, Kontos HA (1981) Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury. J Neurochem 37:892–896PubMedCrossRefGoogle Scholar
  26. Enevoldsen EM, Cold G, Jensen FT (1976) Dynamic changes in regional CBF, intraventricular pressure, CSF, pH and lactate levels during the acute phase of head injury. J Neurosurg 44:191–214PubMedCrossRefGoogle Scholar
  27. Faden AI (1985) Pharmacologic therapy in acute spinal cord injury: experimental strategies and future directions. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 481–485Google Scholar
  28. Faden AI (1990) Opioid and non-opioid mechanisms may contribute to dynorphin’s pathophysiologic actions in spinal cord injury. Ann Neurol 27:67–74PubMedCrossRefGoogle Scholar
  29. Faden AI, Simon RP (1988) A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann Neurol 23:623–626PubMedCrossRefGoogle Scholar
  30. Faden AI, Jacobs TP, Holaday JW (1981) Opiate antagonists improve neurologic recovery after spinal injury. Science 211:493–494PubMedCrossRefGoogle Scholar
  31. Faden AI, Molineaux CJ, Rosenberger JG, Jacobs TP, Cox BM (1985) Endogenous opioid immunoreactivity in rat spinal cord following traumatic injury. Ann Neurol 17:386–390PubMedCrossRefGoogle Scholar
  32. Faden AI, Lemke M, Demediuk P (1988 a) Effects of BW755C, a mixed cyclo-oxygenase-lipoxygenase inhibitor, following traumatic spinal cord injury in rats. Brain Res 463:63–68PubMedCrossRefGoogle Scholar
  33. Faden AI, Lemke M, Simon RP, Noble LJ (1988 b) N-methyl-D-aspartate antagonist MK 801 improves outcome following traumatic spinal cord injury in rats: behavioural, anatomic, and neurochemical studies. J Neurotrauma 5:33–45PubMedCrossRefGoogle Scholar
  34. Faden AI, Sacksen I, Noble LJ (1988 c) Opiate receptor antagonist nalmefene improves neurological recovery after traumatic spinal cord injury in rats through a central mechanism. J Pharmacol Exp Ther 245:742–748PubMedGoogle Scholar
  35. Faden AI, Demediuk P, Panter S, Vink R (1989) Excitatory amino acids, n-methyl-D-aspartate receptors and traumatic brain injury. Science 244:798–800PubMedCrossRefGoogle Scholar
  36. Frankowski RF, Annegers JF, Whitman S (1985) Epidemiological and descriptive studies pt 1: the descriptive epidemiology of head trauma in the United States. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 33–43Google Scholar
  37. Garfinkel L, Garfmkel D (1985) Magnesium regulation of the glycolytic pathway and the enzymes involved. Magnesium 14:60–72Google Scholar
  38. Gennarelli TA, Thibault LE (1985) Biological models of head injury. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 391–404Google Scholar
  39. Ginsburg MD, Mela L, Wrobel-Kuhl K, Reivich M (1977) Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil. Ann Neurol 1:519–527CrossRefGoogle Scholar
  40. Grubbs RD, Maguire ME (1987) Magnesium as a regulatory cation: criteria and evaluation. Magnesium 6:113–127PubMedGoogle Scholar
  41. Gulati SC, Sood SC, Bali IM, Kak VK (1980) Cerebral metabolism following brain injury. Acta Neurochir (Wien) 53:39–51CrossRefGoogle Scholar
  42. Gunther T, Vormann J, Forster R (1984) Functional compartmentation of intracellular magnesium. Magnesium-Bull 6:77–81Google Scholar
  43. Gupta RK, Gupta P, Yushok WD, Rose ZB (1983) On the noninvasive measurement of intracellular free magnesium by 31P NMR spectroscopy. Physiol Chem Phys Med NMR 15:265–280PubMedGoogle Scholar
  44. Gupta RK, Gupta P, Moore RD (1984) NMR studies of intracellular metal ions in intact cells and tissue. Annu Rev Biophys Bioeng 13:221–246PubMedCrossRefGoogle Scholar
  45. Hall ED, McCall JM, Chase RL, Yonkers PA, Braughler JM (1987) A non-glucocorticoid steroid analog af methylprednisolone duplicates its high dose pharmacology in models of central nervous system trauma and neuronal membrane damage. J Pharmacol Exp Ther 242:137–142PubMedGoogle Scholar
  46. Hayes RL, Galinet BJ, Kulkarne P (1983) Effects of naloxone on systemic and cerebral responses to experimental concussive brain injury in cats. J Neurosurg 58:720–728PubMedCrossRefGoogle Scholar
  47. Hayes RL, Jenkins LW, Lyeth BG, Balster RL, Robinson SE, Clifton GL, Stubbins JF, Young HF (1988) Pretreatment with phencyclidine, an n-methyl-D-aspartate antagonist, attenuates long term behavioral deficits in the rat produced by traumatic brain injury. J Neurotrauma 5:259–274PubMedCrossRefGoogle Scholar
  48. Heaton FW (1980) Magnesium in intermediary metabolism. In: Cantin M, Seelig MS (eds) Magnesium in health and disease. Spectrum, New York, pp 43–55Google Scholar
  49. Hillered L, Siesjo BK, Arfors K-E (1984) Mitochondrial response to transient forebrain ischemia and recirculation in the rat. J Cereb Blood Flow Metab 4:438–446PubMedCrossRefGoogle Scholar
  50. Hsu CY, Halushka PV, Hogan EL, Banik NL, Lee WA, Perot LP (1985) Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. Neurology 35:1003–1009PubMedCrossRefGoogle Scholar
  51. Iseri LT, French JH (1984) Magnesium: nature’s physiologic calcium antagonist. Am Heart J 108:188–193PubMedCrossRefGoogle Scholar
  52. Kemp JA, Foster AC, Wong EHF (1987) Noncompetitive antagonists of excitatory amino acid receptors. Trends Neurosci 10:294–298CrossRefGoogle Scholar
  53. Kontos HA, Wei EP, Ellis EF et al. (1985) Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats. Circ Res 57:142–151PubMedCrossRefGoogle Scholar
  54. Kushmerick MJ, Dillon PF, Meyer RA, Brown TR, Krisanda JM, Sweeney HL (1986) 31P NMR spectroscopy, chemical analysis, and free Mg2+ of rabbit bladder and uterine smooth muscle. J Biol Chem 261:14420–14429PubMedGoogle Scholar
  55. Kwo S, Young W, DeCrescito V (1989) Spinal cord sodium, potassium, calcium and water concentration changes in rats after graded contusion injury. J Neurotrauma 6:13–24PubMedCrossRefGoogle Scholar
  56. Lemke M, Demediuk P, Mcintosh TK, Vink R, Faden AI (1987) Alterations in tissue Mg++, Na+ and spinal cord edema following impact trauma in rats. Biochem Biophys Res Commun 149:594–599CrossRefGoogle Scholar
  57. Lemke M, Faden AI (1990) Edema development and ion changes to rat spinal cord after impact trauma: injury dose response studies. J Neurotrauma 7:41–54PubMedCrossRefGoogle Scholar
  58. Lewin MG, Hansebout RH, Pappius HM (1974) Chemical characteristics of traumatic spinal cord edema in cats. J Neurosurg 40:65–75PubMedCrossRefGoogle Scholar
  59. Nayer ML, Westbrook GL, Cuthrie PB (1984) Voltage dependent block by Mg2+ of NMDA receptors in spinal cord neurones. Nature 309:261–263CrossRefGoogle Scholar
  60. Mcintosh TK, Vink R (1989) Biochemical and pathophysiologic mechanisms in experimental mild to moderate traumatic brain injury. In: Doran J Jr, Anderson TE, Cole TM (eds) Contemporary issues in neurological surgery, vol 1; mild to moderate head injury. Black-well, Boston, pp 35–46Google Scholar
  61. Mcintosh TK, Faden AI, Bendall MR, Vink R (1987) Traumatic brain injury in the rat: alterations in brain lactate and pH as characterized by 1H and 31P NMR. J Neurochem 49:1530–1540PubMedCrossRefGoogle Scholar
  62. Mcintosh TK, Faden AI, Yamakami I, Vink R (1988 a) Magnesium deficiency exacerbates and pretreatment improves outcome following traumatic brain injury in rats: 31P magnetic resonance spectroscopy and behavioral studies. J Neurotrauma 5:17–31PubMedCrossRefGoogle Scholar
  63. Mcintosh TK, Vink R, Faden AI (1988 b) An analog of thyrotropin-releasing hormone improves outcome after brain injury: 31P NMR studies. Am J Physiol 254:R785–R792PubMedGoogle Scholar
  64. Mcintosh TK, Soares HL, Hayes RL, Simon RP (1989 a) The n-methyl-D-aspartate receptor antagonist MK 801 prevents edema and restores magnesium homeostasis following traumatic brain injury in rats. In: Leahman J (ed) Recent advances in excitatory amino acid research. Liss, New York, pp 653–656Google Scholar
  65. Mcintosh TK, Vink R, Noble LJ, Yamakami I, Fernyak SE, Soares H, Faden AI (1989 b) Traumatic brain injury in the rat: characterization of a lateral fluid percussion injury model. Neuroscience 28:233–244PubMedCrossRefGoogle Scholar
  66. Mcintosh TK, Vink R, Soares H, Hayes R, Simon R (1989 c) Effects of the N-methyl-D-aspartate receptor blocker MR 801 on neurological function after experimental brain injury. J Neurotrauma 6:247–259Google Scholar
  67. Mcintosh TK, Vink R, Yamakami I, Faden AI (1989 d) Magnesium protects against neurological deficit after brain injury. Brain Res 482:252–260Google Scholar
  68. Mcintosh TK, Vink R, Soares H, Simon RP (1990) Effect of noncompetitive blockade of N-methyl-D-aspartate receptors on the neurochemical sequelae of experimental brain injury. J Neurochem (in press)Google Scholar
  69. Meldrum B (1985) Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters. Clin Sci 68:113–122PubMedCrossRefGoogle Scholar
  70. Nigam R, Averdunk Y, Gunther T (1986) Alteration in prostanoid metabolism in rats with magnesium deficiency. Prostaglandins Leukot Med 23:1–10PubMedCrossRefGoogle Scholar
  71. Nilsson B, Ponten U (1977) Experimental head injury in the rat, pt 2: regional brain energy metabolism in concussive trauma. J Neurosurg 47:252–261PubMedCrossRefGoogle Scholar
  72. Noble LJ, Wrathall JR (1989) Correlative analysis of lesion development and functional status after graded spinal cord contusive injuries in the rat. Exp Neurol 103:34–40PubMedCrossRefGoogle Scholar
  73. Nowak L, Bregestovski P, Ascher P, Herbelt A, Prochiantz A (1984) Magnesium gates glutamate activated channels in mouse central neurones. Nature 307:462–465PubMedCrossRefGoogle Scholar
  74. Olney JW, Price M, Salles K, Labruyere J, Friedrich G (1987) MK 801 powerfully protects against N-methyl-D-aspartate neurotoxicity. Eur J Pharmacol 141:357–361PubMedCrossRefGoogle Scholar
  75. Povlishock JT (1985) The morphopathologic responses to head injuries of varying severity. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 443–452Google Scholar
  76. Rawe SE, Lee WA, Perot PL (1981) Spinal cord glucose utilization after experimental spinal cord injury. Neurosurgery 9:40–47PubMedCrossRefGoogle Scholar
  77. Rivlin AS, Tator CH (1978) Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg Neurol 10:39–43Google Scholar
  78. Robertson CS, Foltz R, Grossman RG, Goodman JC (1986) Protection against experimental ischemic spinal cord injury. J Neurosurg 64:633–642PubMedCrossRefGoogle Scholar
  79. Rosner MJ, Becker DP (1984) Experimental brain injury: successful therapy with the weak base, tromethamine. J Neurosurg 60:961–971PubMedCrossRefGoogle Scholar
  80. Rotevatn S, Murphy E, Levy LA, Raju B, Lieberman M, London RE (1989) Cytosolic free magnesium concentration in cultured chick heart cells. Am J Physiol 257:C141–C146PubMedGoogle Scholar
  81. Rothman SM, Olney JW (1986) Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 19:105–111PubMedCrossRefGoogle Scholar
  82. Rubin H (1976) Magnesium deprivation reproduces the coordinate effects of serum removal or Cortisol addition on transport and metabolism in chick embryo fibroblasts. J Cell Physiol 89:613–626PubMedCrossRefGoogle Scholar
  83. Sadee W, Pfeiffer A, Herz A (1982) Opiate receptors: multiple effects of metal ions. J Neurochem 39:659–667PubMedCrossRefGoogle Scholar
  84. Sandler AN, Tator CH (1976) Review of the effects of spinal cord trauma on vessels and blood flow in the spinal cord. J Neurosurg 45:638–646PubMedCrossRefGoogle Scholar
  85. Saunders RD, Dugan LL, Demediuk P, Means ED, Horrocks LA, Anderson DK (1987) Effects of methylprednisolone and the combination of a-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue. J Neurochem 49:24–31PubMedCrossRefGoogle Scholar
  86. Selecki BR, Simpson DA, Vanderfield GK, Ring I, Sewell MK (1980) The epidemiology of head injury in New South Wales. Proceedings of the 5th annual Brain Impairment Conference, Lidcombe Hospital, SyndeyGoogle Scholar
  87. Siesjo BK (1978) Brain energy metabolism. Wiley, New YorkGoogle Scholar
  88. Siesjo BK, Wieloch T (1985) Brain injury: neurochemical aspects. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 513–532Google Scholar
  89. Stewart WB (1985) Edema in spinal cord injury. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 475–479Google Scholar
  90. Stokes BT, Fox P, Hollinden G (1983) Extracellular calcium activity in the injured spinal cord. Exp Neurol 80:561–572PubMedCrossRefGoogle Scholar
  91. Sullivan HG, Martinez J, Becker DP, Miller JD, Griffith R, Wist AO (1976) Fluid percussion model of mechanical brain injury in the cat. J Neurosurg 45:520–534CrossRefGoogle Scholar
  92. Tarlov IM (1972) Acute spinal cord compression paralysis. J Neurosurg 36:10–20PubMedCrossRefGoogle Scholar
  93. Tornheim PA (1985) Traumatic edema in head injury. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 431–442Google Scholar
  94. Vacanti FX, Ames A (1984) Mild hypotension and Mg2+ protect against irreversible damage during CNS ischemia. Stroke 15:695–698PubMedCrossRefGoogle Scholar
  95. Veloso D, Guynn RW, Oskarsson M, Veech RL (1973) The concentration of free and bound magnesium in rat tissues. J Biol Chem 248:4811–4819PubMedGoogle Scholar
  96. Vink R, Mcintosh TK, Demediuk P, Faden AI (1987 a) Decrease in total and free magnesium concentration following traumatic brain injury in rats. Biochem Biophys Res Commun 149:594–599PubMedCrossRefGoogle Scholar
  97. Vink R, Mcintosh TK, Weiner MW, Faden AI (1987 b) Effects of traumatic brain injury on cerebral high energy phosphates and intracellular pH: a 31P magnetic resonance spectroscopy study. J Cereb Blood Flow Metab 7:563–571PubMedCrossRefGoogle Scholar
  98. Vink R, Faden AI, Mcintosh TK (1988 a) Changes in cellular bioenergetic state following graded traumatic brain injury in rats: determination by phosphorus-31 magnetic resonnance spectroscopy. J Neurotrauma 5:105–119PubMedCrossRefGoogle Scholar
  99. Vink R, Mcintosh TK, Demediuk P, Weiner MW, Faden AI (1988 b) Decline in intracellular free magnesium concentration is associated with irreversible tissue injury following brain trauma. J Biol Chem 263:757–761PubMedGoogle Scholar
  100. Vink R, Mcintosh TK, Faden AI (1988 c) Treatment with the thyrotropin-releasing hormone analog CG3703 restores magnesium homeostasis following traumatic brain injury in rats. Brain Res 460:184–188PubMedCrossRefGoogle Scholar
  101. Vink R, Mcintosh TK, Yamakami I, Faden AI (1988d) 31P NMR characterization of graded traumatic brain injury in rats. Magn Reson Med 6:37–48PubMedCrossRefGoogle Scholar
  102. Vink R, Noble LJ, Knoblach SM, Bendall MR, Faden AI (1989 a) Metabolic changes in rabbit spinal cord after trauma: magnetic resonance spectrocopy studies. Ann Neurol 25:26–31PubMedCrossRefGoogle Scholar
  103. Vink R, Yum SW, Lemke M, Demediuk P, Faden AI (1989 b) Traumatic spinal cord injury in rabbits decreases intracellular free magnesium concentration as measured by 31P MRS. Brain Res 490:144–147PubMedCrossRefGoogle Scholar
  104. Vink R, Mcintosh TK, Rhomhanyi R, Faden A (1990) Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state and neurologic outcome following traumatic brain injury in rats. J Neurosci (in press)Google Scholar
  105. Walker JG, Yates RR, O’Neill JJ, Yashon D (1977) Canine spinal cord energy state after experimental trauma. J Neurochem 29:929–932PubMedCrossRefGoogle Scholar
  106. Wagner KR, Tornheim PA, Eichold ME (1985) Acute changes in regional cerebral metabolite values following experimentalblunt head trauma. J Neurosurg 63:88–96PubMedCrossRefGoogle Scholar
  107. Wei EP, Lamb RG, Kontos HA (1982) Increased phospholipase C activity after experimental brain injury. J Neurosurg 56:695–698PubMedCrossRefGoogle Scholar
  108. Wong EHF, Kemp JA, Priestley T (1986) The novel anticonvulsant MK 801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 83:7104–7109PubMedPubMedCentralCrossRefGoogle Scholar
  109. Yamakami I, Mcintosh TK (1989) Effects of traumatic brain injury on regional cerebral blood flow in rats as measured with radiolabeled microspheres. J Cereb Blood Flow Metab 9:117–124PubMedCrossRefGoogle Scholar
  110. Yang MS, DeWitt DS, Becker DP, Hayes RL (1985) Regional brain metabolite levels following mild experimental head injury in the cat. J Neurosurg 63:617–621PubMedCrossRefGoogle Scholar
  111. Yoshida S, Busto R, Martinez E, Scheinberg P, Ginsburg MD (1985) Regional brain energy metabolism after complete versus incomplete ischemia in the rat in the absence of severe lactic acidosis. J Cereb Blood Flow Metab 5:490–501PubMedCrossRefGoogle Scholar
  112. Young W (1985 a) Blood flow, metabolic and neurophysiological mechanisms in spinal cord injury. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report 1985. National Institute of Health, Bethesda, pp 463–473Google Scholar
  113. Young W (1985 b) The role of calcium in spinal cord injury. CNS Trauma 2:109–114Google Scholar
  114. Young W, Flamm ES, Demopoulos HB, Tomasula JJ, DeCrescito V (1981) Naloxone ameliorates posttraumatic ischemia in experimental spinal contusion. J Neurosurg 55:209–219PubMedCrossRefGoogle Scholar
  115. Yuan X-Q, Prough DS, Smith TL, Dewitt DS (1988) The effects of traumatic brain injury on regional cerebral blood flow in rats. J Neurotrauma 5:289–301PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Robert Vink
    • 1
  • Tracy K. McIntosh
    • 2
  • Alan I. Faden
    • 3
  1. 1.Department of Chemistry and BiochemistryJames Cook University of North QueenslandTownsvilleAustralia
  2. 2.Department of SurgeryUniversity of Connecticut Health CenterFarmingtonUSA
  3. 3.Department of NeurologyUniversity of California School of Medicine, and Veterans Administration Medical CenterSan FranciscoUSA

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