Mg2+ in Neurotrauma: Its Role and Therapeutic Implications

  • Robert Vink
  • Tracy K. McIntosh
  • Alan I. Faden

Abstract

In Western, developed countries such as the USA, UK, New Zealand, and Australia, injury to the brain or spinal cord results in more deaths in individuals under 44 years of age than all other causes of death (Selecki et al. 1980; Frankowski et al. 1985). As such it can be considered the primary killer of young people in these countries. Aside from the significant mortality and morbidity associated with central nervous system (CNS) injury, in financial terms the cost to the community for hospitalization and rehabilitation runs into billions of dollars per year. Recent developments suggest that much of the injury associated with CNS trauma can be prevented. While some of the tissue damage associated with the development of irreversible injury occurs at the time of injury, much of it is delayed, arising hours to days after the initial insult (Cooper 1985). Recognition of the factors that contribute to the development of irreversible injury permits development of “antifactors” that may attenuate or even prevent manifestation. This review will concentrate on one factor that has been receiving increasing attention in the study of neurotrauma: Mg2+.

Keywords

Permeability Ischemia Lactate Cortisol Respiration 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Robert Vink
    • 1
  • Tracy K. McIntosh
    • 2
  • Alan I. Faden
    • 3
  1. 1.Department of Chemistry and BiochemistryJames Cook University of North QueenslandTownsvilleAustralia
  2. 2.Department of SurgeryUniversity of Connecticut Health CenterFarmingtonUSA
  3. 3.Department of NeurologyUniversity of California School of Medicine, and Veterans Administration Medical CenterSan FranciscoUSA

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