Mechanism of Action and Clinical Use of Prostanoids

  • Giovanni de Gaetano
  • Vittorio Bertelé
  • Chiara Cerletti

Abstract

Aspirin reduces cardiovascular mortality most likely by suppressing platelet thromboxane A2 (T×A2) generation, despite a variable degree of inhibition of vascular prostacyclin (PGI2) production [1]. This implies that suppression of platelet activatory and vasoconstrictory prostanoids is clinically beneficial and that such a benefit is not hidden by the concomitant reduced availability of prostanoids provided with opposite biological effects, such as PGE1 and PGI2. However, the prominent role of T×A2 does not rule out the possibility thatpromotion of endogenous PGI2 production or administration of exogenous analogues may have a therapeutic effect in particular clinical situations.

Keywords

Placebo Cholesterol Ischemia Noradrenaline Gall 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Giovanni de Gaetano
  • Vittorio Bertelé
  • Chiara Cerletti

There are no affiliations available

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