Somatosensory Regeneration Following Peripheral Nerve Injury

  • A. Struppler
  • G. Ochs
Conference paper

Abstract

A variety of regenerative processes are known to occur in the peripheral and central nervous system after nerve trauma (Devor and Wall 1981; Dykes and Terzis 1979; Horch and Lisney 1981; McGregor et al. 1984). As a consequence, typical positive and negative symptoms occur during recovery, even in the chronic situation, when plastic reorganization has reached a steady state (Sunderland 1978; Merle et al. 1986; Noordenbos 1979). Nevertheless, many questions remain to be answered concerning sensory disturbances encountered in patients.

Keywords

Ischemia Neurol Peri Stein Lost 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aschan W, Moberg E (1962) The Ninhydrin finger printing test used to map out partial lesions to hand nerves. Acta Chir Scand 123:365–370.PubMedGoogle Scholar
  2. Brink EE, Mackel R (1987) Sensorimotor performance of the hand during peripheral nerve regeneration. J Neurolog Sci 77:249–266.CrossRefGoogle Scholar
  3. Devor M, Wall PD (1981) Plasticity in the spinal cord sensory map following peripheral nerve injury in rats. J Neurosci 7:679–684.Google Scholar
  4. Dykes RW, Terzis JK (1979) Reinnervation of glabrous skin in baboons: properties of cutaneous mechanoreceptors subsequent to nerve crush. J Neurophysiol 42:1461–1478.PubMedGoogle Scholar
  5. Hallin RG, Wiesenfeld Z, Lindblom U (1981) Neurophysiological studies on patients with sutured median nerves: faulty sensory localization after nerve regeneration and its physiological correlates. Exp Neurology 73:90–106.CrossRefGoogle Scholar
  6. Horch K (1979) Guidance of regrowing sensory axons after cutaneous nerve lesions in the cat. J Neurophysiol 5:1437–1449.Google Scholar
  7. Horch KW, Lisney SJW (1981) Changes in primary afferent depolarisation of sensory neurons during peripheral nerve regeneration in the cat. J Physiol (Lond) 313:287–299.Google Scholar
  8. Johansson RS, Vallbo AB (1979) Tactile sensibility in the human hand: relative and absolute densities of 4 types of mechanoreceptive units in glabrous skin. J Physiol 286:283–300.PubMedGoogle Scholar
  9. Knibestöl M, Vallbo AB (1979) Single unit analysis of mechanoreceptor activity from the human glabrous skin. Acta Physiol Scand 44:178–195.Google Scholar
  10. Knyihar E, Csillik B (1976) Effect of peripheral axotomy on the fine structure and histochemistry of the rolando substance: degenerative atrophy and central processes of pseudounipolar cells. Exp Brain Res 26:73–87.PubMedCrossRefGoogle Scholar
  11. Lindblom U, Merskey H, Mumford JM, Nathan PW, Noordenbos W, Sunderland S (1985) Pain terms — a current list with definitions and notes on usage with definitions and notes on usage. Pain, Suppl. 3:215–221.Google Scholar
  12. Mackel R (1985) Human cutaneous mechanoreceptors during regeneration: physiology and interpretation. Ann Neurol 18:165–172.PubMedCrossRefGoogle Scholar
  13. Mackel R, Kunesch E, Waldhör F, Struppler A (1983) Reinnervation of mechanoreceptors in the human glabrous skin following peripheral nerve repair. Brain Res 268:49–65.PubMedCrossRefGoogle Scholar
  14. Mackel R, Brink EE, Wittkowsky G (1985) Properties of cutaneous mechanosensitive afferents during the early stages of regeneration in man. Brain Res 329:49–69.PubMedCrossRefGoogle Scholar
  15. McGregor GP, Gibson SJ, Sabate IM, Blank MA, Christofides ND, Wall PD, Polak JM, Boom SR (1984) Effect of peripheral nerve section and nerve crush on spinal cord neuropeptides in the rat: increased VIP and PIH in the dorsal horn. Neurosci 13:207–216.CrossRefGoogle Scholar
  16. Merle M, Amand P, Cour C, Foucher G, Michon J (1986) Microsurgical repair of peripheral nerve lesions — a study of 150 injuries of the median and ulnar nerve. Periph Nerve Rep Reg 2:17–26.Google Scholar
  17. Merzenich MM, Kaas JH, Sur M, Lin CS (1978) Double representation of the body surface within the cytoarchitectonic area 3 b and 1 in “S-I” in the owl monkey. J Comp Neurol 181:41–73.PubMedCrossRefGoogle Scholar
  18. Merzenich MM, Nelson RJ, Stryker MP, Cynader MS, Schoppmann A, Zook JM (1984) Somatosensory cortical map changes following digit amputation in adult monkeys. J Comp Neurol 224:591–605.PubMedCrossRefGoogle Scholar
  19. Noordenbos W (1979) Sensory findings in painful traumatic nerve lesions. Advances in pain Research and Therapy, Vol. 3. Raven Press, New York.Google Scholar
  20. Ochoa J, Torebjörk HE (1983) Sensations evoked by intraneural microstimulation of single mechanoreceptor units innervating the human hand. J Physiol 342:33–54.Google Scholar
  21. Ochs G, Schenk M, Struppler A (1989) Painful dysaesthesias following peripheral nerve injury: a clinical and electrophysiological study. Brain Res 496, 1–2:228-240.CrossRefGoogle Scholar
  22. Renehan WE, Munger BL (1986) Degeneration and regeneration of peripheral nerve in the rat trigeminal system. II. Response to nerve lesion. J Comp Neurol 249:429–459.PubMedCrossRefGoogle Scholar
  23. Sanders KH, Zimmermann M (1986) Mechanoreceptors in rat glabrous skin: redevelopment of function after nerve crush. J Neurophysiol 55:644–659.PubMedGoogle Scholar
  24. Schady WJL, Torebjörk HE (1983) Projected and receptive fields: a comparison of projected areas of sensations evoked by intraneural stimulation of mechanoreceptive units and their innervation territories. Acta Physiol Scand 119:267–285.PubMedCrossRefGoogle Scholar
  25. Schady WJL, Ochoa J, Torebjörk HE, Chen LS (1983) Peripheral projections of fascicles in the human median nerve. Brain 106:745–760.PubMedCrossRefGoogle Scholar
  26. Struppler A, Mackel R, Besinger U, Waldhör F (1981) Electromyography and Microneurography following Peripheral Nerve Transplantations. In: Gorio A, Millesi H, Mingrino S (eds) Posttraumatic Peripheral Nerve Regeneration. Raven Press, New York, 581–589.Google Scholar
  27. Sunderland S (1978) Nerve and nerve injuries, 2nd ed. Churchill Livingston, London.Google Scholar
  28. Terzis JK, Dykes RW (1980) Reinnervation of glabrous skin in baboons: properties of cutaneous mechanoreceptors subsequent to nerve transection. J Neurophysiol 44:1214–1225.PubMedGoogle Scholar
  29. Thomas CK, Stein RB, Gordon T, Lee RG, Elleker MG (1987) Patterns of reinnervation and motor unit recruitment in human hand muscles after complete ulnar and median nerve section and resuture. J Neurol Neurosurg Psychiat 50:259–268.PubMedCrossRefGoogle Scholar
  30. Vallbo AB, Hagbarth KE (1968) Activity from skin mechanoreceptors recorded percutaneously in awake human subjects. Exp Neurol 21:270–289.PubMedCrossRefGoogle Scholar
  31. Vallbo AB, Johansson RS (1984) Properties of cutaneous mechanoreceptors in the human hand related to touch sensation. Human Neurobiology 3:3–14.PubMedGoogle Scholar
  32. Wall JT, Kaas JH, Sur M, Nelson RJ, Fellmann DJ, Merzenich MM (1986) Functional reorganization in somatosensory cortical areas 3 b and 1 of adult monkeys after median nerve repair: possible relationships to sensory recovery in humans. J Neurosci 6:218–233.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • A. Struppler
    • 1
  • G. Ochs
    • 1
  1. 1.MünchenGermany

Personalised recommendations