Abstract
To achieve successful recovery of sensory functions after peripheral nerve injury, the affected population of sensory ganglion cells must (a) survive the axon injury, (b) produce axonal sprouts, (c) maintain and support the elongation of the sprouting axons, (d) participate in neuron-nonneuronal cell and neuron-target interactions, and (e) reintegrate properly in the functional system. Abundant clinical experience demonstrates that this series of events is frequently seriously disturbed. Over the last 10–15 years an increasing amount of information has accumulated which demonstrates that axotomized sensory ganglion cells undergo degenerative changes. The present report focuses on our present knowledge about the nature of these changes, the possible pathogenetic mechanisms for their development, and their possible significance for the deficient restitution of sensory functions after peripheral nerve injury.
This research was supported by the Swedish Medical Research Council (Project 5420) and by grants from the Karolinska Institute and the Åke Wibergs Foundation.
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References
Aldskogius H, Arvidsson J, Grant G (1985) The reaction of primary sensory neurons to peripheral nerve injury with particular emphasis on transganglionic changes. Brain Res 10:27–46.
Arvidsson J (1986) Transganglionic degeneration in vibrissae innervating primary sensory neurons of the rat: a light and electron microscopic study. J Comp Neurol 249:392–403.
Arvidsson J, Ygge J, Grant G (1986) Cell loss in lumbar dorsal root ganglia and transganglionic degeneration after sciatic nerve resection in the rat. Brain Res 373:15–21.
Austin L, Langford CJ (1980) Nerve regeneration: a biochemical view. Trends in Neurosci, May:130-132.
Castro-Lopes JM, Coimbra A, Grant G (1987) Ultrastructural changes of primary afferent endings in the spinal cord substantia gelatinosa during transganglionic degeneration. Neurosci 22: S713.
Csillik B, Knyihar-Csillik, E (1981) Regenerative synaptogenesis in the mammalian spinal cord: dynamics of synaptochemical restoration in the Rolando substance after transganglionic degenerative atrophy. J Neural Transm 53:303–317.
Devor M (1983) Plasticity of spinal cord somatotopy in adult mammals: involvement of relatively ineffective synapses. Birth Defects: Original Article Series 19:287–314.
Fields HL, Emson PC, Leigh BK, Gilbert RFT, Iversen LL (1980) Multiple opiate receptor sites on primary afferent fibres. Nature (Lond) 284:351–353.
Fitzgerald M, Wall PD, Goedert M, Emson PE (1985) Nerve growth factor counteracts the neurophysiological effects of chronic sciatic nerve section. Brain Res 332:131–141.
Gilmore SA, Leiting JE (1984) Immunostaining of astrocytes following sciatic axotomy. Anat Rec 208:61A.
Heumann R, Korshing S, Bandtlow C, Thoenen H (1987) Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection. J Cell Biol 104:1623–1631.
Horch KW, Lisney SJW (1981) Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the cat. J Physiol (Lond) 313:287–299.
Hunt SP, Rossor MN, Emson PC, Clement-Jones V (1982) Substance P and enkephalins in spinal cord after limb amputation. Lancet 8279:1023.
Jessell T, Tsunoo A, Kanawawa I, Otsuka M (1979) Substance P: depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons. Brain Res 168:247–259.
Knyihar-Csillik E, Csillik B (1981) FRAP: histochemistry of the primary nociceptive neuron. Progr Histochem Cytochem, Vol 14. G. Fischer, Stuttgart New York.
Markus H, Pomeranz B, Krushelnycky D (1984) Spread of saphenous somatotopic projection map in spinal cord and hypersensitivity of the foot after chronic sciatic denervation. Brain Res 296:27–39.
McGregor GP, Gibson SJ, Sabate IM, Blank MA, Christofides ND, Wall PD, Polak JM, Bloom SR (1984) Effect of peripheral nerve section and nerve crush on spinal cord neuropeptides in the rat: increased VIP and PHI in the dorsal horn. Neurosci 13:207–216.
McQuarrie IG (1983) Role of the axonal cytoskeleton in the regenerating nervous system. In: Seil F (ed) Nerve, organ, and tissue regeneration. Academic Press, London New York, pp 51–88.
Persson J, Arvidsson J, Aldskogius H (1987) Changes in dorsal root ganglion neurons projecting to the gracile nucleus after sciatic nerve transection in the rat. Neurosci 22: S251.
Peyronnard JM, Messier A, Charron L, Lavoie J, Bergouignan FX, Dubreuil M (1986) Carbonic anhydrase activity in the normal and injured peripheral nervous system. Exp Neurol 93:481–499.
Redshaw JD, Bisby MA (1985) Comparison of the effects of sciatic nerve crush or resection on the proteins of fast axonal transport in rat dorsal root ganglion cell axons. Exp Neurol 88:437–446.
Rich KM, Luszczynski JR, Osborne PA, Johnson EM Jr (1987) Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury. J Neurocytol 16:261–268.
Richardson PM, Issa VMK (1984) Peripheral nerve injury enhances central regeneration of primary sensory neurons. Nature (Lond) 309:791–793.
Sjöberg J, Kanje M (1987) Incorporation of (32 P) phosphate into nucleoteides of the dorsal root ganglia of regenerating rat sciatic nerve. Brain Res 415:270–274.
Skene JHP, Willard M (1981) Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous system. J Cell Biol 89:96–103.
Wall PD, Devor M (1981) The effect of peripheral nerve injury on dorsal root potentials and on transmission of afferent signals into the spinal cord. Brain Res 209:95–111.
Woolf CJ, Wall PD (1982) Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones. Brain Res 242:77–85.
Ygge J, Aldskogius H (1984) Intercostal nerve transection and its effect on the dorsal root ganglion. A quantitative study on ganglion cell numbers and sizes. Exp Brain Res 55:402–408.
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© 1990 Springer-Verlag Berlin Heidelberg
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Aldskogius, H. (1990). The Response of Sensory Ganglia and Spinal Cord to Injury. In: Samii, M. (eds) Peripheral Nerve Lesions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75611-5_3
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DOI: https://doi.org/10.1007/978-3-642-75611-5_3
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