Experimental Peripheral Nerve Crush Lesion II. Short-Term Reinnervation Changes in Fast Muscle Fibers
From the clinical point of view, quality of muscle reinnervation following peripheral nerve injury constitutes a crucial element in the assessment of effectiveness of nerve repair. We analyzed this problem in a standardized experimental paradigm in the rat. By means of morphometrical, histochemical, and ultrastructural methods we studied acute posttraumatic changes in selected parameters indicating reinnervation of single fibers in extensor digitorum longus (EDL) and extensor hallucis longus (EHL) muscles following a standardized crush injury of the peroneal nerve. We quantified these changes 2 and 4 weeks postinjury against the background provided by those developing in a parallel experimental group in which muscle reinnervation was prevented by peroneal nerve unrepaired excision. These muscles represent predominantly the fast type and are identical in histochemical profile, ultrastructure, and the time course of reinnervation. A preliminary report has been published .
KeywordsFatigue Formaldehyde Citrate Epoxy Adenosine
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