Biochemical Manipulation of the Microenvironment in Experimental Nerve Regeneration Chambers

  • H. Müller
Conference paper

Abstract

Despite improved microsurgical techniques, the results of peripheral nerve repair very often remain unsatisfactory [1–4]. Therefore, studies aimed at a better identification and potential manipulation of the cellular and molecular events in PNS regeneration are still meaningful to both scientists and clinicians [5].

Keywords

Nerve Regeneration Peripheral Nerve Regeneration Exogenous Ganglioside Silicone Chamber Biochemical Manipulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Müller H (1978) Dokumentation und Analyse klinischer Resultate nach Nervennähten. Doct. Thesis. University of Hamburg.Google Scholar
  2. 2.
    Müller H, Grubel G (1981) Long-term results of peripheral nerve sutures — a comparison of micro-and macrosurgical techniques. Adv Neurosurg 9:381–387.CrossRefGoogle Scholar
  3. 3.
    Müller H, Grubel G (1982) Periphere Nervenverletzungen: Indikation und Ergebnisse der frühen Sekundärversorgung. Hefte Unfallheilkd 158:453–459.PubMedGoogle Scholar
  4. 4.
    Müller H, Grubel G (1983) Factors influencing peripheral nerve suture results. Arch Orthop Trauma Surg 102:51–55.PubMedCrossRefGoogle Scholar
  5. 5.
    Lundborg G (1988) Nerve injury and repair. Churchill Livingstone, New York.Google Scholar
  6. 6.
    Lundborg G, Gelberman RH, Longo FM, Powell HC, Varon S (1982) In vivo regeneration of cut nerves encased in silicone tubes. J Neuropath Exp Neurol 41:412–422.PubMedCrossRefGoogle Scholar
  7. 7.
    Lundborg G, Dahlin LB, Danielsen N, Gelberman RH, Longo FM, Powell HC, Varon S (1982) Nerve regeneration in silicone chambers: influence of gap length and of distal stump components. Exp Neurol 76:361–375.PubMedCrossRefGoogle Scholar
  8. 8.
    Lundborg G, Longo FM, Varon S (1982) Nerve regeneration model and trophic factors in vivo. Brain Res 232:157–161.PubMedCrossRefGoogle Scholar
  9. 9.
    Weiss P (1944) Sutureless reunion of severed nerves with elastic cuffs of tantalum. J Neurosurg 1:219–225.CrossRefGoogle Scholar
  10. 10.
    Weiss P (1944) The technology of nerve regeneration: a review. Sutureless tubulation and related methods of nerve repair. J Neurosurg 1:400–450.CrossRefGoogle Scholar
  11. 11.
    Campbell JB, Bassett CAL, Husby J, Thulin CA, Feringa ER (1961) Microfilter sheaths in peripheral nerve surgery. J Trauma 1:139–155.CrossRefGoogle Scholar
  12. 12.
    Kline DG, Hayes GJ (1964) The use of a resorbable wrapper for peripheral-nerve repair. Experimental studies in chimpanzees. J Neurosurg 21:737–750.PubMedCrossRefGoogle Scholar
  13. 13.
    Lehmann RAW, Hayes GJ (1967) Degeneration and regeneration in peripheral nerve. Brain 90y:285–296.CrossRefGoogle Scholar
  14. 14.
    Midgley RD, Woolhouse FM (1968) Silastic sheating technique for the anastomoses of nerves and tendons. Canad Med Ass J 98:550–551.PubMedGoogle Scholar
  15. 15.
    Williams LR, Longo FM, Powell HC, Lundborg G, Varon S (1983) Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. J Comp Neurol 218:460–470.PubMedCrossRefGoogle Scholar
  16. 16.
    Williams LR, Müller H, Margolin L, Varon S (1985) The rat as a model for the study of peripheral nerve regeneration within a silicone chamber. Abstract. 36th Ann Bess Amer Assoc Lab Animal Sci, Baltimore.Google Scholar
  17. 17.
    Müller H, Shibib K, Friedrich H, Modrack M (1987) Evoked muscle action potentials from regenerated rat tibial and peroneal nerves: synthetic versus autologous interfascicular grafts. Exp Neurol 95:21–33.PubMedCrossRefGoogle Scholar
  18. 18.
    Müller H, Shibib K, Modrack M, Friedrich H (1987) Nerve regeneration in synthetic and autologous interfascicular grafts. II. Morphometric analysis. Exp Neurol 98:1, p 161-169.CrossRefGoogle Scholar
  19. 19.
    Jenq CB, Coggeshall RE (1986) The effects of an autologous transplant on patterns of regeneration in rat sciatic nerve. Brain Res 364:45–56.PubMedCrossRefGoogle Scholar
  20. 20.
    Molander H, Engkvist O, Haaglund J, Olsson Y, Torebjörk E (1983) Nerve repair using a polyglactin tube and nerve graft: an experimental study in the rabbit. Biomaterials 4:276–280.PubMedCrossRefGoogle Scholar
  21. 21.
    Longo FM, Skaper SD, Manthorpe M, Williams LR, Lundborg G, Varon S (1983) Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers. Exp Neurol 81:756–769.PubMedCrossRefGoogle Scholar
  22. 22.
    Longe FM, Hayman EG, Davis GE, Ruoslahti E, Engvall E, Manthorpe M, Varon S (1984) Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers. Brain Res 309:105–117.CrossRefGoogle Scholar
  23. 23.
    Williams LR, Varon S (1985) Modification of vibrin matrix formation in situ enhances nerve regeneration in silicone chambers. J Comp Neurol 231:209–220.PubMedCrossRefGoogle Scholar
  24. 24.
    Williams LR, Danielsen N, Müller H, Varon S (1987) Exogenous matrix precursors promote functional nerve regeneration across a 15 mm gap within a silicone chamber in the rat. J Comp Neurol 231.Google Scholar
  25. 25.
    Müller H, Williams LR, Varon S (1987) Nerve regeneration chamber: evaluation of exogenous agents applied by multiple injections. Brain Res 413:320–326.PubMedCrossRefGoogle Scholar
  26. 26.
    Davis G, Manthorpe M, Engvall E, Varon S (1985) Isolation and characterization of rat schwannoma neurite-promoting factor: evidence that the factor contains laminin. J Neurosci 5:2662–2671.PubMedGoogle Scholar
  27. 27.
    Ide C, Tohyama K, Yokota R, Nitatori T, Onodera S (1983) Schwann cell basal lamina and nerve regeneration. Brain Res 288:61–75.PubMedCrossRefGoogle Scholar
  28. 28.
    Manthorpe M, Engvall E, Ruoslahti E, Longo FM, Davis GE, Varon S (1983) Laminin promotes neuritic regeneration from cultured peripheral and central neurons. J Cell Biol 97:1882–1890.PubMedCrossRefGoogle Scholar
  29. 29.
    Madison R, Silva CF da, Dikkes P, Sidman RL, Chiu TH (1985) Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. Exp Neurol 88:767–772.PubMedCrossRefGoogle Scholar
  30. 30.
    Patterson PH (1985) On the role of proteases, their inhibitors and the extracellular matrix in promoting neurite outgrowth. J de Physiol 80:207–211.Google Scholar
  31. 31.
    Lander AD, Fujii DK, Gospodarowisz D, Reichardt LF (1984) Neurite outgrowthpromoting factors in conditioned media are complexes containing laminin. Abstract. Soc Neurosci 10:1614.Google Scholar
  32. 32.
    Timpl R, Rohde H, Robey PG, Rennard SI, Foidart JM, Martin GR (1979) Laminin — a glycoprotein from basement membranes. J Biol Chem 254:9933–9937.PubMedGoogle Scholar
  33. 33.
    Hannouche N, Samperez S, Jouan P (1980) Accumulation of 5 alpha-dihydrotestosterone in purified plasma membranes and in the myelin of male rat hypothalamus. CR Soc Biol 174:963–968.Google Scholar
  34. 34.
    Sar M, Stumpf WE (1977) Androgen concentration in motor neurons of cranial nerves and spinal cord. Science 197:77–79.PubMedCrossRefGoogle Scholar
  35. 35.
    Snyder EY, Kim SU (1979) Hormonal requirements for neuronal survival in culture. Neurosci Lett 13:225–230.PubMedCrossRefGoogle Scholar
  36. 36.
    Yu WHA (1982) Effect of testosterone on the regeneration of the hypoglossal nerve in rats. Exp Neurol 77:129–141.PubMedCrossRefGoogle Scholar
  37. 37.
    Facci L, Leon A, Toffano G, Sonino S, Ghidoni R, Tettamanti G (1984) Promotion of neuritogenesis in mouse neuroblastoma cells by exogenous gangliosides. Relationship between the effect and the cell association of ganglioside GM1. J Neurochem 42:299–305.PubMedCrossRefGoogle Scholar
  38. 38.
    Ferrari G, Fabris M, Gorio G (1983) Gangliosides enhance neurite outgrowth in PC 12 cells. Dev Brain Res 8:215–222.CrossRefGoogle Scholar
  39. 39.
    Gorio A, Carmignoto G, Facci L, Finesso M (1980) Motor nerve sprouting induced by ganglioside treatment. Possible implications for gangliosides on neuronal growth. Brain Res 197:236–241.PubMedCrossRefGoogle Scholar
  40. 40.
    Gorio A, Marini P, Zanoni R (1984) Muscle reinnervation. III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides. Neuroscience 8:417–429.CrossRefGoogle Scholar
  41. 41.
    Katoh-Semba R, Skaper SD, Varon S (1984) Interaction of GM1 ganglioside with PC 12 pheochromocytoma cells: serum-and NGF-dependent effects on neurite growth (and proliferation). J Neurosci Res 12:299–310.PubMedCrossRefGoogle Scholar
  42. 42.
    Skaper SD, Katoh-Semba R, Varon S (1985) GM1 ganglioside accelerates neurite outgrowth from primary peripheral and central neurons under selected culture conditions. Dev Brain Res 23:19–26.CrossRefGoogle Scholar
  43. 43.
    Walicke P, Varon S, Manthorpe M (1986) Purification of a human red blood cell protein supporting the survival of cultured CNS neurons, and its identification as catalase. J Neurosci 6:1114–1121.PubMedGoogle Scholar
  44. 44.
    Müller H (1988) Further evaluation of the effects of laminin, testosterone, ganglioside GM1, and catalase on early growth in rat nerve regeneration chambers. Exp Neurol 101:2, p 228-233.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. Müller
    • 1
  1. 1.LübeckGermany

Personalised recommendations