Biochemical Manipulation of the Microenvironment in Experimental Nerve Regeneration Chambers

  • H. Müller
Conference paper

Abstract

Despite improved microsurgical techniques, the results of peripheral nerve repair very often remain unsatisfactory [1–4]. Therefore, studies aimed at a better identification and potential manipulation of the cellular and molecular events in PNS regeneration are still meaningful to both scientists and clinicians [5].

Keywords

Testosterone Neurol Androgen Catalase Neuroblastoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Müller H (1978) Dokumentation und Analyse klinischer Resultate nach Nervennähten. Doct. Thesis. University of Hamburg.Google Scholar
  2. 2.
    Müller H, Grubel G (1981) Long-term results of peripheral nerve sutures — a comparison of micro-and macrosurgical techniques. Adv Neurosurg 9:381–387.CrossRefGoogle Scholar
  3. 3.
    Müller H, Grubel G (1982) Periphere Nervenverletzungen: Indikation und Ergebnisse der frühen Sekundärversorgung. Hefte Unfallheilkd 158:453–459.PubMedGoogle Scholar
  4. 4.
    Müller H, Grubel G (1983) Factors influencing peripheral nerve suture results. Arch Orthop Trauma Surg 102:51–55.PubMedCrossRefGoogle Scholar
  5. 5.
    Lundborg G (1988) Nerve injury and repair. Churchill Livingstone, New York.Google Scholar
  6. 6.
    Lundborg G, Gelberman RH, Longo FM, Powell HC, Varon S (1982) In vivo regeneration of cut nerves encased in silicone tubes. J Neuropath Exp Neurol 41:412–422.PubMedCrossRefGoogle Scholar
  7. 7.
    Lundborg G, Dahlin LB, Danielsen N, Gelberman RH, Longo FM, Powell HC, Varon S (1982) Nerve regeneration in silicone chambers: influence of gap length and of distal stump components. Exp Neurol 76:361–375.PubMedCrossRefGoogle Scholar
  8. 8.
    Lundborg G, Longo FM, Varon S (1982) Nerve regeneration model and trophic factors in vivo. Brain Res 232:157–161.PubMedCrossRefGoogle Scholar
  9. 9.
    Weiss P (1944) Sutureless reunion of severed nerves with elastic cuffs of tantalum. J Neurosurg 1:219–225.CrossRefGoogle Scholar
  10. 10.
    Weiss P (1944) The technology of nerve regeneration: a review. Sutureless tubulation and related methods of nerve repair. J Neurosurg 1:400–450.CrossRefGoogle Scholar
  11. 11.
    Campbell JB, Bassett CAL, Husby J, Thulin CA, Feringa ER (1961) Microfilter sheaths in peripheral nerve surgery. J Trauma 1:139–155.CrossRefGoogle Scholar
  12. 12.
    Kline DG, Hayes GJ (1964) The use of a resorbable wrapper for peripheral-nerve repair. Experimental studies in chimpanzees. J Neurosurg 21:737–750.PubMedCrossRefGoogle Scholar
  13. 13.
    Lehmann RAW, Hayes GJ (1967) Degeneration and regeneration in peripheral nerve. Brain 90y:285–296.CrossRefGoogle Scholar
  14. 14.
    Midgley RD, Woolhouse FM (1968) Silastic sheating technique for the anastomoses of nerves and tendons. Canad Med Ass J 98:550–551.PubMedGoogle Scholar
  15. 15.
    Williams LR, Longo FM, Powell HC, Lundborg G, Varon S (1983) Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. J Comp Neurol 218:460–470.PubMedCrossRefGoogle Scholar
  16. 16.
    Williams LR, Müller H, Margolin L, Varon S (1985) The rat as a model for the study of peripheral nerve regeneration within a silicone chamber. Abstract. 36th Ann Bess Amer Assoc Lab Animal Sci, Baltimore.Google Scholar
  17. 17.
    Müller H, Shibib K, Friedrich H, Modrack M (1987) Evoked muscle action potentials from regenerated rat tibial and peroneal nerves: synthetic versus autologous interfascicular grafts. Exp Neurol 95:21–33.PubMedCrossRefGoogle Scholar
  18. 18.
    Müller H, Shibib K, Modrack M, Friedrich H (1987) Nerve regeneration in synthetic and autologous interfascicular grafts. II. Morphometric analysis. Exp Neurol 98:1, p 161-169.CrossRefGoogle Scholar
  19. 19.
    Jenq CB, Coggeshall RE (1986) The effects of an autologous transplant on patterns of regeneration in rat sciatic nerve. Brain Res 364:45–56.PubMedCrossRefGoogle Scholar
  20. 20.
    Molander H, Engkvist O, Haaglund J, Olsson Y, Torebjörk E (1983) Nerve repair using a polyglactin tube and nerve graft: an experimental study in the rabbit. Biomaterials 4:276–280.PubMedCrossRefGoogle Scholar
  21. 21.
    Longo FM, Skaper SD, Manthorpe M, Williams LR, Lundborg G, Varon S (1983) Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers. Exp Neurol 81:756–769.PubMedCrossRefGoogle Scholar
  22. 22.
    Longe FM, Hayman EG, Davis GE, Ruoslahti E, Engvall E, Manthorpe M, Varon S (1984) Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers. Brain Res 309:105–117.CrossRefGoogle Scholar
  23. 23.
    Williams LR, Varon S (1985) Modification of vibrin matrix formation in situ enhances nerve regeneration in silicone chambers. J Comp Neurol 231:209–220.PubMedCrossRefGoogle Scholar
  24. 24.
    Williams LR, Danielsen N, Müller H, Varon S (1987) Exogenous matrix precursors promote functional nerve regeneration across a 15 mm gap within a silicone chamber in the rat. J Comp Neurol 231.Google Scholar
  25. 25.
    Müller H, Williams LR, Varon S (1987) Nerve regeneration chamber: evaluation of exogenous agents applied by multiple injections. Brain Res 413:320–326.PubMedCrossRefGoogle Scholar
  26. 26.
    Davis G, Manthorpe M, Engvall E, Varon S (1985) Isolation and characterization of rat schwannoma neurite-promoting factor: evidence that the factor contains laminin. J Neurosci 5:2662–2671.PubMedGoogle Scholar
  27. 27.
    Ide C, Tohyama K, Yokota R, Nitatori T, Onodera S (1983) Schwann cell basal lamina and nerve regeneration. Brain Res 288:61–75.PubMedCrossRefGoogle Scholar
  28. 28.
    Manthorpe M, Engvall E, Ruoslahti E, Longo FM, Davis GE, Varon S (1983) Laminin promotes neuritic regeneration from cultured peripheral and central neurons. J Cell Biol 97:1882–1890.PubMedCrossRefGoogle Scholar
  29. 29.
    Madison R, Silva CF da, Dikkes P, Sidman RL, Chiu TH (1985) Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. Exp Neurol 88:767–772.PubMedCrossRefGoogle Scholar
  30. 30.
    Patterson PH (1985) On the role of proteases, their inhibitors and the extracellular matrix in promoting neurite outgrowth. J de Physiol 80:207–211.Google Scholar
  31. 31.
    Lander AD, Fujii DK, Gospodarowisz D, Reichardt LF (1984) Neurite outgrowthpromoting factors in conditioned media are complexes containing laminin. Abstract. Soc Neurosci 10:1614.Google Scholar
  32. 32.
    Timpl R, Rohde H, Robey PG, Rennard SI, Foidart JM, Martin GR (1979) Laminin — a glycoprotein from basement membranes. J Biol Chem 254:9933–9937.PubMedGoogle Scholar
  33. 33.
    Hannouche N, Samperez S, Jouan P (1980) Accumulation of 5 alpha-dihydrotestosterone in purified plasma membranes and in the myelin of male rat hypothalamus. CR Soc Biol 174:963–968.Google Scholar
  34. 34.
    Sar M, Stumpf WE (1977) Androgen concentration in motor neurons of cranial nerves and spinal cord. Science 197:77–79.PubMedCrossRefGoogle Scholar
  35. 35.
    Snyder EY, Kim SU (1979) Hormonal requirements for neuronal survival in culture. Neurosci Lett 13:225–230.PubMedCrossRefGoogle Scholar
  36. 36.
    Yu WHA (1982) Effect of testosterone on the regeneration of the hypoglossal nerve in rats. Exp Neurol 77:129–141.PubMedCrossRefGoogle Scholar
  37. 37.
    Facci L, Leon A, Toffano G, Sonino S, Ghidoni R, Tettamanti G (1984) Promotion of neuritogenesis in mouse neuroblastoma cells by exogenous gangliosides. Relationship between the effect and the cell association of ganglioside GM1. J Neurochem 42:299–305.PubMedCrossRefGoogle Scholar
  38. 38.
    Ferrari G, Fabris M, Gorio G (1983) Gangliosides enhance neurite outgrowth in PC 12 cells. Dev Brain Res 8:215–222.CrossRefGoogle Scholar
  39. 39.
    Gorio A, Carmignoto G, Facci L, Finesso M (1980) Motor nerve sprouting induced by ganglioside treatment. Possible implications for gangliosides on neuronal growth. Brain Res 197:236–241.PubMedCrossRefGoogle Scholar
  40. 40.
    Gorio A, Marini P, Zanoni R (1984) Muscle reinnervation. III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides. Neuroscience 8:417–429.CrossRefGoogle Scholar
  41. 41.
    Katoh-Semba R, Skaper SD, Varon S (1984) Interaction of GM1 ganglioside with PC 12 pheochromocytoma cells: serum-and NGF-dependent effects on neurite growth (and proliferation). J Neurosci Res 12:299–310.PubMedCrossRefGoogle Scholar
  42. 42.
    Skaper SD, Katoh-Semba R, Varon S (1985) GM1 ganglioside accelerates neurite outgrowth from primary peripheral and central neurons under selected culture conditions. Dev Brain Res 23:19–26.CrossRefGoogle Scholar
  43. 43.
    Walicke P, Varon S, Manthorpe M (1986) Purification of a human red blood cell protein supporting the survival of cultured CNS neurons, and its identification as catalase. J Neurosci 6:1114–1121.PubMedGoogle Scholar
  44. 44.
    Müller H (1988) Further evaluation of the effects of laminin, testosterone, ganglioside GM1, and catalase on early growth in rat nerve regeneration chambers. Exp Neurol 101:2, p 228-233.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. Müller
    • 1
  1. 1.LübeckGermany

Personalised recommendations