Abstract
In nerve grafting today a biological two-component tissue adhesive is commonly used to fixate the nerve grafts to the nerve stumps. Several reports have shown that this technique offers the same functional results as the microsuturing technique but is easier to apply and considerably more time saving. Several factors have been described to promote nerve regeneration by increasing the number of outgrowing nerve fibers. These substances include nerve growth factor [1], the peptide hormones ACTH4–10 [2], ACTH4–9, and alpha-melanocortine [3]. In several experimental studies from the University of Utrecht [3–5], the melanotropic neuropeptides have been shown to stimulate the nerve axon outgrowth, both by systemic and local application.
This research was supported by a grant from Immuno A/S, Denmark.
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References
Richardson PM, Ebendal T, Riopelle RJ (1985) Nerve growth and nerve growth factor within peripheral nervous tissue. In: Björklund A, Stenevi U (eds) Neural grafting in the mammalian. Elsevier Science Publishers, pp 319–327.
Bijlsma WA, Jennekens FGI, Schotman P, Gispen W-H (1983) Stimulation by ACTH4–10 of nerve fiber regeneration following sciatic nerve crush. Muscle & Nerve 6:104–112.
Edwards PM, Van der Zee CEEM, Verhagen J, Schotman P, Jennekens FGI, Gispen W-H (1984) Evidence that the neurotrophic actions of a-MSH may derive from its ability to mimic the actions of a peptide formed in degeneration nerve stumps. J Neurol Sci 64:333–340.
Bijlsma WA, Schotman P, Jennekens FGI, Gispen W-H, Wied D (1983) The enhanced recovery of sensimotor functions in rat is related to the melanotropic moiety of ACTH/MSH neuropeptides. Europ J Pharmacol 92:231–236.
Verhagen J, Edwards PM, Jennekens FGI, Schotman P, Gispen W-H (1986) α-Melanocyte-stimulating hormone (α-MSH) stimulates the outgrowth of myelinated nerve fibers after peripheral nerve crush. Exp Neurol 92(2): 451–454.
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© 1990 Springer-Verlag Berlin Heidelberg
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Osgaard, O., Diemer, N.H. (1990). Stimulation of Nerve Axon Outgrowth by Means of Fibrin Adhesive with Added Melanotropic Neuropeptide. In: Samii, M. (eds) Peripheral Nerve Lesions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75611-5_12
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DOI: https://doi.org/10.1007/978-3-642-75611-5_12
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