Poxvirus Expression Vectors
The poxviruses form a large family of complex DNA viruses that infect both vertebrate and invertebrate hosts. The most notorious member, variola virus, was responsible for smallpox, one of the most dreaded of all infectious diseases. In the late 18th century, Edward Jenner demonstrated that smallpox could be prevented by immunization with a more benign relative, vaccinia virus, which caused mild infections in cattle. Ultimately, global vaccination strategies led to the eradication of smallpox.
KeywordsCodon Recombination Influenza Sarcoma Nucleoside
Unable to display preview. Download preview PDF.
- Davison AJ, Moss B (1991a) The structure of vaccinia virus early promoters. J Mol Biol (in press)Google Scholar
- Davison AJ, Moss B (1991b) The structure of vaccinia virus late promoters. J Mol Biol (in press)Google Scholar
- Elango N, Prince GA, Murphy BR, Venkatesan S, Chanock RM, Moss B (1986) Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein. Proc Natl Acad Sci USA 83: 1906–1911PubMedCrossRefGoogle Scholar
- Mackett M, Smith GL, Moss B (1985) The construction and characterization of vaccinia virus recombinants expressing foreign genes. DNA cloning. IRL Press, OxfordGoogle Scholar
- Moss B (1985) Replication of poxviruses. In: Virology. Raven, New YorkGoogle Scholar
- Paoletti E, Lipinskas BR, Samsonoff C, Mercer SR, Panicali D (1984) Construction of live vaccines using genitically engineered poxviruses: biological acitivity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus glycoprotein D. Proc Natl Acad Sci USA 81: 193–197PubMedCrossRefGoogle Scholar
- Shida H, Tochikura T, Sato T, Konno T, Hirayoshi K, Seki M, Ito Y, Hatanaka M, Hinuma Y, Sugimoto M, Takahashi-Nisimaki F, Maruyama T, Miki K, Suzuki K, Morita M, Sashiyama H, Hayami M (1987) Effect of the recombinant vaccina viruses that express HTLV-I envelope gene on HTLV-I infection. EMBO J 6: 3379–3384PubMedGoogle Scholar
- Stomatos N, Chakrabarti S, Moss B, Hare DJ (1987) Expression of polyomavirus virion proteins by a vaccinia virus vector: association of VP1 and VP2 with the nuclear framework. J Virol 61: 516–525Google Scholar
- Yuen L, Moss B (1987) Oligonucleotide sequence signaling transcriptional termination of vaccinia virus early genes. Proc Natl Acad Sci USA 84: 6717–6421Google Scholar