Poxvirus Expression Vectors

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 158)


The poxviruses form a large family of complex DNA viruses that infect both vertebrate and invertebrate hosts. The most notorious member, variola virus, was responsible for smallpox, one of the most dreaded of all infectious diseases. In the late 18th century, Edward Jenner demonstrated that smallpox could be prevented by immunization with a more benign relative, vaccinia virus, which caused mild infections in cattle. Ultimately, global vaccination strategies led to the eradication of smallpox.


Vaccinia Virus Foreign Gene Vesicular Stomatitis Virus Recombinant Vaccinia Virus Vaccinia Virus Vector 
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Copyright information

© Springer-Verlag Berlin·Heidelberg 1992

Authors and Affiliations

  • B. Moss
    • 1
  1. 1.Laboratory of Viral DiseasesNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA

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