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Recombinant Vaccinia Viruses As Vectors for Studying T Lymphocyte Specificity and Function

  • Conference paper
Poxviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 163))

Abstract

Over the past 20 years, a steadily increasing portion of immunological research has been directed towards understanding the specificity and function of T lymphocytes. Vaccinia virus (VV) has proven to be the preferred vector for determining the specificity of T lymphocytes for individual gene products derived from a variety of organisms, including viruses, protozoa, and mammalian cells (we refer to these genes as “extrinsic genes”, their products as “extrinsic antigens” and their origin as “source organisms”) and for studying the processing and presentation of antigens to T lymphocytes by antigen presenting cells (APCs). The popularity of VV recombinants has two sources. First, the technology of producing VV recombinants is relatively straightforward and VV recombinants consistently provide high levels of expression of extrinsic antigens. Second, studies of T lymphocytes require the expression of antigens in histocompatible cells. The ability of VV to infect mice and a broad variety of mouse and human cell lines of diverse lineages that can function as APCs make them ideal vectors for studies of T lymphocytes.

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Bennink, J.R., Yewdell, J.W. (1990). Recombinant Vaccinia Viruses As Vectors for Studying T Lymphocyte Specificity and Function. In: Moyer, R.W., Turner, P.C. (eds) Poxviruses. Current Topics in Microbiology and Immunology, vol 163. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75605-4_6

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