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Poxviruses pp 125-151 | Cite as

The Molecular Pathogenesis of Poxviruses

  • P. C. Turner
  • R. W. Moyer
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 163)

Abstract

Over the years, there have been a number of excellent reviews and articles which discuss aspects of orthopoxvirus virulence and pathogenesis (Fenner 1948a; Fenner 1948b; Fenner 1949a; Fenner 1949b; Fenner and Cairns 1959; Mims 1964; Blanden 1970; Blanden 1971a; Blanden 1971b; Jacoby et al. 1983; Jacoby and Bhatt 1987; Bhatt and Jacoby 1987a; Bhatt and Jacoby 1987b; Bhatt et al. 1988; Fenner et al. 1988a; Fenner et al. 1988b; Joklik et al. 1988). In particular, we would refer readers to the recent, excellent book by Fenner, Wittek and Dumbell (1989) upon which we have drawn extensively for this review and that provides over 40 years of personal perspectives on the subject.

Keywords

Vaccinia Virus Inverted Terminal Repetition Myxoma Virus Fowlpox Virus Cowpox Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Archard LC, Mackett M (1979) Restriction endonuclease analysis of red cowpox virus and its white pock variant. J Gen Virol 45: 51–63PubMedGoogle Scholar
  2. Archard LC, Mackett M, Barnes DE, Dumbell KR (1984) The genome structure of cowpox virus white pock variants. J Gen Virol 65: 875–886PubMedGoogle Scholar
  3. Ball LA (1987) High-frequency homologous recombination in vaccinia virus DNA. J Virol 61: 1788–1795PubMedGoogle Scholar
  4. Baroudy BM, Venkatesan S, Moss B (1982) Incompletely base-paired flip-flop terminal loops link the two DNA strands of the vaccinia virus genome into one uninterrupted polynucleotide chain. Cell 28: 315–324PubMedGoogle Scholar
  5. Baroudy BM, Venkatesan S, Moss B (1983) Structure and replication of vaccinia virus telomeres. Cold Spring Harbor Symp Quant Biol 47: 723–729PubMedGoogle Scholar
  6. Bearcroft WGC, Jamieson MF (1958) Yaba tumor virus. An outbreak of subcutaneous tumours in rhesus monkeys. Nature 182: 195–196PubMedGoogle Scholar
  7. Bedson HS, Dumbell KR (1964a) Hybrids derived from the viruses of alastrim and rabbit pox. J Hyg (Lond) 62: 141–146Google Scholar
  8. Bedson HS, Dumbell KR (1964b) Hybrids derived from the viruses of variola major and cowpox. J Hyg (Lond) 62: 147–158Google Scholar
  9. Berns KI, Silverman C (1970) Natural occurrence of cross-linked vaccinia virus deoxyribonucleic acid. J Virol 5: 299–304PubMedGoogle Scholar
  10. Bhatt PN, Jacoby RO (1987a) Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus III. Experimental transmission of infection and derivation of virus-free progeny from previously infected dams. Lab Anim Sci 37: 22–28Google Scholar
  11. Bhatt PN, Jacoby RO (1987b) Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus I. Clinical responses. Lab Anim Sci 37: 11–15PubMedGoogle Scholar
  12. Bhatt PN, Jacoby RO, Gras L (1988) Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus. IV. Studies with the Moscow strain. Arch Virol 100: 221–230PubMedGoogle Scholar
  13. Binns MM, Tomley FM, Campbell J, Boursnell ME (1988) Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene. J Gen Virol 69: 1275–1283PubMedGoogle Scholar
  14. Blanden RV (1970) Mechanisms of recovery from a generalized viral infection: mousepox I. The effects of anti-thymocyte serum. J Exp Med 132: 1035–1054PubMedGoogle Scholar
  15. Blanden RV (1971a) Mechanisms of recovery from a generalized viral infection: mousepox III. Regression infectious foci. J Exp Med 133: 1090–1104PubMedGoogle Scholar
  16. Blanden RV (1971b) Mechanisms of recovery from a generalized viral infection: mousepox II. Passive transfer of recovery mechanisms with immune lymphoid cells. J Exp Med 133: 1074–1089PubMedGoogle Scholar
  17. Block W, Upton C, McFadden G (1985) Tumorigenic poxviruses: genomic organization of malignant rabbit virus, a recombinant between Shope fibroma virus and myxoma virus. Virology 140: 113–124PubMedGoogle Scholar
  18. Blomquist MC, Hunt LT, Barker WC (1984) Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors. Proc Natl Acad Sci USA 81: 7363–7367PubMedGoogle Scholar
  19. Boursnell ME, Foulds IJ, Campbell JI, Binns MM (1988) Non-essential genes in the vaccinia virus HindIII K fragment: a gene related to serine protease inhibitors and a gene related to the 37K vaccinia virus major envelope antigen. J Gen Virol 69: 2995–3003PubMedGoogle Scholar
  20. Brown GD, Moyer RW (1983) The white pock mutants of rabbit poxvirus: V. In vitro translation of early host range mutant mRNA. Virology 126: 381–390PubMedGoogle Scholar
  21. Brown GD, Peluso RW, Moyer SA, Moyer RW (1983) A simple method for the preparation of extracts from animal cells which catalyze efficient in vitro protein synthesis. J Biol Chem 258: 14309–14314PubMedGoogle Scholar
  22. Brown JP, Twardzik DR, Marquardt H, Todaro GJ (1985) Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor. Nature 313: 491–492PubMedGoogle Scholar
  23. Brown ST, Nalley JF, Kraus SJ (1981) Molluscum contagiosum. Sex Transm Dis 8: 227–234PubMedGoogle Scholar
  24. Buller RM, Smith GL, Cremer K, Notkins AL, Moss B (1985) Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype. Nature 317: 813–815PubMedGoogle Scholar
  25. Buller RM, Chakrabarti S, Moss B, Fredrickson T (1988a) Cell proliferative response to vaccinia virus is mediated by VGF. Virology 164: 182–192PubMedGoogle Scholar
  26. Buller RM, Chakrabarti S, Cooper JA, Twardzik DR, Moss B (1988b) Deletion of the vaccinia virus growth factor gene reduces virus virulence. J Virol 62: 866–874PubMedGoogle Scholar
  27. Chang W, Upton C, Hu SL, Purchio AF, McFadden G (1987) The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha. Mol Cell Biol 7: 535–540PubMedGoogle Scholar
  28. Chang W, Lim JG, Hellstrom I, Gentry LE (1988) Characterization of vaccinia virus growth factor biosynthetic pathway with an antipeptide antiserum. J Virol 62: 1080–1083PubMedGoogle Scholar
  29. Chernos VI, Antonova TP, Senkevich TG (1985) Recombinants between vaccinia and ectromelia viruses bearing the specific pathogenicity markers of both parents. J Gen Virol 66: 621–626PubMedGoogle Scholar
  30. Cooper JA, Wittek R, Moss B (1981) Hybridization selection and cell-free translation of mRNAs encoded within the inverted terminal repetition of the vaccinia virus genome. J Virol 37: 284–294PubMedGoogle Scholar
  31. Dallo S, Esteban M (1987) Isolation and characterization of attenuated mutants of vaccinia virus. Virology 159:408–422PubMedGoogle Scholar
  32. Dallo S, Rodriguez JF, Esteban M (1987) A 14 K envelope protein of vaccinia virus with an important role in virus-host cell interactions is altered during virus persistence and determines the plaque size phenotype of the virus. Virology 159: 423–432PubMedGoogle Scholar
  33. DeFilippes FM (1982) Restriction enzyme mapping of vaccinia virus DNA. J Virol 43: 136–149PubMedGoogle Scholar
  34. Downie AW, Haddock DW (1952) A variant of cowpox virus. Lancet I:1049–1050Google Scholar
  35. Drillien R, Spehner D, Kirn A (1978) Host range restriction of vaccinia virus in Chinese hamster ovary cells: relationship to shutoff of protein synthesis. J Virol 28: 843–850PubMedGoogle Scholar
  36. Drillen R, Koehren F, Kirn A (1981) Host range deletion mutant of vaccinia virus defective in human cells. Virology 111: 488–499Google Scholar
  37. Drillien R, Spehner D, Villeval D, Lecocq JP (1987) Similar genetic organization between a region of fowlpox virus DNA and the vaccinia virus HindIII J fragment despite divergent location of the thymidine kinase gene. Virology. 160: 203–209PubMedGoogle Scholar
  38. Dumbell KR, Archard LC (1980) Comparison of white pock (h) mutants of moneypox virus with parental monkeypox and with variola-like viruses isolated from animals. Nature 286: 29–32PubMedGoogle Scholar
  39. Edwards KM, Andrews TC, Van Savage J, Palmer PS, Moyer RW (1988) Poxvirus deletion mutants: virulence and immunogenicity. Microbial Pathogenesis 4: 325–333PubMedGoogle Scholar
  40. Esposito JJ, Obijeski JF, Nakano JH (1978) Orthopoxvirus DNA: strain differentiation by electrophoresis of restriction endonuclease fragmented virion DNA. Virology 89: 53–66PubMedGoogle Scholar
  41. Esposito JJ, Cabradilla CD, Nakano JH, Obijeski JF (1981) Intragenomic sequence transposition in monkeypox virus. Virology 109: 231–243PubMedGoogle Scholar
  42. Esposito JJ, Knight JC (1985) Orthopoxvirus DNA: a comparison of restriction profiles and maps. Virology 143:230–251PubMedGoogle Scholar
  43. Esteban M, Benavente J, Paez E (1986) Mode of sensitivity and resistance of vaccinia virus replication to interferon. J Gen Virol 67: 801–808PubMedGoogle Scholar
  44. Fenner F (1948a) The pathogenesis of the acute exanthems. An interpretation based on experimental investigations with mousepox (infectious ectromelia of mice). Lancet II: 915–920Google Scholar
  45. Fenner F (1948b) The clinical features of mouse-pox (infectious ectromelia of mice) and the pathogenesis of the disease. J Pathol Bacteriol 60: 529–552Google Scholar
  46. Fenner F (1949a) Studies in mousepox (infectious ectromelia of mice). VI. A comparison of the virulence and infectivity of three strains of ectromelia virus. Aust J Exp Biol Med Sci 27: 31–50PubMedGoogle Scholar
  47. Fenner F (1949b) Mouse-pox (infectious ectromelia of mice): a review. J Immunol 63: 341–373PubMedGoogle Scholar
  48. Fenner F (1958) The biological characters of several strains of vaccinia, cowpox and rabbitpox viruses. Virology 5: 502–529PubMedGoogle Scholar
  49. Fenner F, Cairns J (1959) Variation in virulence in relation to adaptation to new hosts. In: Burnet FM, Stanley WM (eds) The viruses. Vol 3. Academic, New York, pp 225–249Google Scholar
  50. Fenner F, Sambrook JF (1966) Conditional lethal mutants of rabbitpox virus. II. Mutants (p) that fail to multiply in PK-2a cells. Virology 28: 600–609PubMedGoogle Scholar
  51. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID (1988a) Variola virus and the other orthopoxviruses. In: Smallpox and its eradication. World Health Organization, Geneva, pp 69–120Google Scholar
  52. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID (1988b) The pathogenesis, pathology and immunology of smallpox and vaccinia. In: Smallpox and its eradication. World Health Organization, Geneva, pp 121–168Google Scholar
  53. Fenner F, Wittek R, Dumbell KR (1989) The orthopoxviruses. Academic, New YorkGoogle Scholar
  54. Flexner C, Hugin A, Moss B (1987) Prevention of vaccinia virus infection in immunodeficient mice by vector-directed IL-2 expression. Nature 330: 259–262PubMedGoogle Scholar
  55. Funahashi S, Sato T, Shida H (1988) Cloning and characterization of the gene encoding the major protein of the A-type inclusion body of cowpox virus. J Gen Virol 69: 35–47PubMedGoogle Scholar
  56. Gangemi JD, Sharp DG (1976) Use of a restriction endonuclease in analyzing the genomes from two different strains of vaccinia virus. J Virol 20: 319–323PubMedGoogle Scholar
  57. Garon CF, Barbosa E, Moss B (1978) Visualization of an inverted terminal repetition in vaccinia virus DNA. Proc Natl Acad Sci USA 75: 4863–4867PubMedGoogle Scholar
  58. Gemmell A, Fenner F (1960) Genetic studies with mammalian poxviruses. III. White (u) mutants of rabbitpox virus. Virology 11: 219–235PubMedGoogle Scholar
  59. Gershon PD, Black DN (1989) The nucleotide sequence around the capripoxvirus thymidine kinase gene reveals a gene shared specifically with leporipoxvirus. J Gen Virol. 70: 525–533PubMedGoogle Scholar
  60. Geshelin P, Berns KI (1974) Characterization and localization of the naturally occurring cross-links in vaccinia virus DNA. J Mol Biol 88: 785–796PubMedGoogle Scholar
  61. Gillard S, Spehner D, Drillien R (1985) Mapping of a vaccinia host range sequence by insertion into the viral thymidine kinase gene. J Virol 53: 316–318PubMedGoogle Scholar
  62. Gillard S, Spehner D, Drillien R, Kirn A (1986) Localization and sequence of a vaccinia virus gene required for multiplication in human cells. Proc Natl Acad Sci USA 83: 5573–5577PubMedGoogle Scholar
  63. Gillard S, Spehner D, Drillien R, Kirn A (1989) Antibodies directed against a synthetic peptide enable detection of a protein encoded by a vaccinia virus host range gene that is conserved within the Orthopoxvirus genus. J Virol 63: 1814–1817PubMedGoogle Scholar
  64. Grady LJ, Paoletti E (1977) Molecular complexity of vaccinia DNA and the presence of reiterated sequences in the genome. Virology 79: 337–341PubMedGoogle Scholar
  65. Hruby DE, Lynn DL, Condit RC, Kates JR (1980) Cellular differences in the molecular mechanisms of vaccinia virus host range restriction. J Gen Virol 47: 485–488PubMedGoogle Scholar
  66. Jacoby RO, Bhatt PN (1987) Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus II. Pathogenesis. Lab Anim Sci 37: 16–22PubMedGoogle Scholar
  67. Jacoby RO, Smith AL, Bhatt PN (1982) Viral disease research. In: The mouse in biomedical research. (Experimental biology and oncology vol 4.) Academic, New York, pp. 169–211Google Scholar
  68. Jacoby RO Bhatt PN, Johnson EA, Paturzo FX (1983) Pathogenesis of vaccinia (IHD-T) virus infection in BALB/cAnN mice. Lab Anim Sci 33: 435–441PubMedGoogle Scholar
  69. Joklik WK, Pickup DJ, Patel DD, Moody MD (1988) Virulence genes of poxviruses and reoviruses. Vaccine 6: 123–128PubMedGoogle Scholar
  70. King CS, Cooper JA, Moss B, Twardzik DR (1986) Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors. Mol Cell Biol 6: 332–336PubMedGoogle Scholar
  71. Kotwal GJ, Moss B (1988a) Analysis of a large cluster of nonessential genes deleted from a vaccinia virus terminal transposition mutant. Virology 167: 524–537PubMedGoogle Scholar
  72. Kotwal GJ, Moss B (1988b) Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins. Nature 335: 176–178PubMedGoogle Scholar
  73. Kotwal GJ, Moss B (1989) Vaccinia virus encodes two proteins that are structurally related to members of the plasma serine protease inhibitor superfamily. J Virol 63: 600–606PubMedGoogle Scholar
  74. Kotwal GJ, Hugin AW, Moss B (1989) Mapping and insertional mutagenesis of a vaccinia virus gene encoding a 13,800-Da secreted protein. Virology 171: 579–587PubMedGoogle Scholar
  75. Lai AC, Pogo BG (1989a) Characterization of vaccinia virus deletion mutants isolated from persistently infected Friend erythroleukemia cells. Virus Res 12: 239–250PubMedGoogle Scholar
  76. Lai AC, Pogo BG (1989b) Attenuated deletion mutants of vaccinia virus lacking the vaccinia growth factor are defective in replication in vivo. Microb Pathog 6: 219–226PubMedGoogle Scholar
  77. Lake JR, Cooper PD (1980) Deletions of the terminal sequences in the genomes of the white pock (u) and host-restricted (p) mutants of rabbitpox virus. J Gen Virol 48: 135–147PubMedGoogle Scholar
  78. Maa, JS, Esteban M (1987) Structural and functional studies of a 39,000-Mr immunodominant protein of vaccinia virus. J Virol 61: 3910–3919PubMedGoogle Scholar
  79. Mackett M, Archard LC (1979) Conservation and variation in Orthopoxvirus genome structure. J Gen Virol 45: 683–701PubMedGoogle Scholar
  80. McCarron RJ, Cabrera CV, Esteban M, McAllister WT, Holowczak JA (1978) Structure of vaccinia DNA: analysis of the viral genome by restriction endonucleases. Virology 86: 88–101PubMedGoogle Scholar
  81. McClain ME (1965) The host range and plaque morphology of rabbitpox virus (RPu+) and its u mutants on chick fibroblast, PK-2a, and L929 cells. Aust J Exp Biol Med Sci 42: 31–44Google Scholar
  82. McClain ME, Greenland RM (1965) Recombination between rabbitpox virus mutants in permissive and nonpermissive cells. Virology 25: 516–522PubMedGoogle Scholar
  83. Mims CA (1964) Aspects of the pathogenesis of virus diseases. Bacteriol Rev 28: 30–71PubMedGoogle Scholar
  84. Moss B, Flexner C (1987) Vaccinia virus expression vectors. Annu Rev Immunol 5: 305–324PubMedGoogle Scholar
  85. Moss B, Winters E, Cooper JA (1981) Deletion of a 9,000-base-pair segment of the vaccinia virus genome that encodes nonessential polypeptides. J Virol 40: 387–395PubMedGoogle Scholar
  86. Moyer RW, Graves RL (1981) The mechanism of cytoplasmic orthopoxvirus DNA replication. Cell 27: 391–401PubMedGoogle Scholar
  87. Moyer RW, Graves RL (1982) The white pock mutants of rabbit poxvirus IV. The late white pock (rau) host range (hr) mutants of rabbit poxvirus are blocked in morphogenesis. Virology 119: 332–346PubMedGoogle Scholar
  88. Moyer RW, Rothe CT (1980) The white pock mutants of rabbit poxvirus. I. Spontaneous host range mutants contain deletions. Virology 102: 119–132PubMedGoogle Scholar
  89. Moyer RW, Graves RL, Rothe CT (1980a) The white pock (mu) mutants of rabbit poxvirus III. Terminal DNA sequence duplication and transposition in rabbit poxvirus. Cell 22: 545–553PubMedGoogle Scholar
  90. Moyer RW, Brown GD, Graves RL (1980b) The white pock mutants of rabbit poxvirus II. The early white pock (mu) host range (hr) mutants of rabbit poxvirus uncouple transcription and translation in nonpermissive cells. Virology 106: 234–249PubMedGoogle Scholar
  91. Muller HK, Wittek R, Schaffner W, Schumperli D, Menna A, Wyler R (1978) Comparison of five poxvirus genomes by analysis with restriction endonucleases HindIII BamI and Eco RI. J Gen Virol 38: 135–147PubMedGoogle Scholar
  92. Paez E, Esteban M (1985) Interferon prevents the generation of spontaneous deletions at the left terminus of vaccinia virus DNA. J Virol 56: 75–84PubMedGoogle Scholar
  93. Paez E, Dallo S, Esteban M (1985) Generation of a dominant 8-MDa deletion at the left terminus of vaccinia virus DNA. Proc Natl Acad Sci USA 82: 3365–3369PubMedGoogle Scholar
  94. Paez E, Dallo S, Esteban M (1987) Virus attenuation and identification of structural proteins of vaccinia virus that are selectively modified during virus persistence. J Virol 61:2642–2647PubMedGoogle Scholar
  95. Panicali D, Davis SW, Mercer SR, Paoletti E (1981) Two major DNA variants present in serially propagated stocks of the WR strain of vaccinia virus. J Virol 37: 1000–1010PubMedGoogle Scholar
  96. Patel DD, Pickup DJ, Joklik WK (1986) Isolation of cowpox virus A-type inclusions and characterization of their major protein component. Virology 149: 174–189PubMedGoogle Scholar
  97. Pedrali Noy G, Weissbach A (1977) Evidence of a repetitive sequence in vaccinia virus DNA. J Virol 24: 406–407Google Scholar
  98. Perkus ME, Panicali D, Mercer S, Paoletti E (1986) Insertion and deletion mutants of vaccinia virus. Virology 152: 285–297PubMedGoogle Scholar
  99. Pickup DJ, Ink BS, Parsons BL, Hu W, Joklik WK (1984) Spontaneous deletions and duplications of sequences in the genome of cowpox virus. Proc Natl Acad Sci USA 81: 6817–6821PubMedGoogle Scholar
  100. Pickup DJ, Ink BS, Hu W, Ray CA, Joklik WK (1986) Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. Proc Natl Acad Sci USA 83: 7698–7702PubMedGoogle Scholar
  101. Porter CD, Archard LC (1987) Characterization and physical mapping of Molluscum contagiosum virus DNA and location of a sequence capable of encoding a conserved domain of epidermal growth factor. J Gen Virol 68: 673–682PubMedGoogle Scholar
  102. Reisner AH (1985) Similarity between the vaccinia virus 19K early protein and epidermal growth factor. Nature 313: 801–803PubMedGoogle Scholar
  103. Rodriguez D, Rodriguez JR, Rodriguez JF, Trauber D, Esteban M (1989) Highly attenuated vaccinia virus mutants for the generation of safe recombinant viruses. Proc Natl Acad Sci USA 86: 1287–1291PubMedGoogle Scholar
  104. Rodriguez JF, Esteban M (1987) Mapping and nucleotide sequence of the vaccinia virus gene that encodes a 14-kilodalton fusion protein. J Virol 61: 3550–3554PubMedGoogle Scholar
  105. Rodriguez JF, Janeczko R, Esteban M (1985) Isolation and characterization of neutralizing monoclonal antibodies to vaccinia virus. J Virol 56: 482–488PubMedGoogle Scholar
  106. Rodriguez JF, Paez E, Esteban M (1987) A 14,000-Mr envelope protein of vaccinia virus is involved in cell fusion and forms covalently linked trimers. J Virol 61: 395–404PubMedGoogle Scholar
  107. Sambrook JF, Mcclain ME, Easterbrook KB, McAuslan BR (1965). A mutant of rabbitpox virus defective at different stages of its multiplication in three cell types. Virology 26: 738–745PubMedGoogle Scholar
  108. Shida H, Hinuma Y, Hatanaka M et al. (1988) Effects and virulences of recombinant vaccinia viruses derived from attenuated strains that express the human T-cell leukemia virus type I envelope gene. J Virol 62: 4474–4480PubMedGoogle Scholar
  109. Slabaugh MB, Mathews CK (1984) Vaccinia virus-induced ribonucleotide reductase can be distinguished from host cell activity. J Virol 52: 501–506PubMedGoogle Scholar
  110. Slabaugh MB, Johnson TL, Mathews CK (1984) Vaccinia virus induces ribonucleotide reductase in primate cells. J Virol 52: 507–514PubMedGoogle Scholar
  111. Slabaugh M, Roseman N, Davis R, Mathews C (1988) Vaccinia virus-encoded ribonucleotide reductase: sequence conservation of the gene for the small subunit and its amplification in hydroxyurea-resistant mutants. J Virol 62: 519–527PubMedGoogle Scholar
  112. Smith GL, Moss B (1983) Infectious poxvirus vectors have capacity for at least 25,000 base pairs of foreign DNA. Gene 25: 21–28PubMedGoogle Scholar
  113. Spehner D, Gillard S, Drillien R, Kirn A (1988) A cowpox virus gene required for multiplication in Chinese hamster ovary cells. J Virol 62: 1297–1304PubMedGoogle Scholar
  114. Strayer DS, Sell S (1983) Immunohistology of malignant rabbit fibroma virus—a comparative study with rabbit myxoma virus. JNCI 71: 105–116PubMedGoogle Scholar
  115. Strayer DS, Cabirac G, Sell S, Leibowitz JL (1983a) Malignant rabbit fibroma virus: observations on the culture and histopathologic characteristics of a new virus-induced rabbit tumor. JNCI 71: 91–104PubMedGoogle Scholar
  116. Strayer DS, Skaletsky E, Cabirac GF et al. (1983b) Malignant rabbit fibroma virus causes secondary immunosuppression in rabbits. J Immunol 130: 399–404PubMedGoogle Scholar
  117. Stroobant P, Rice AP, Gullick WJ, Cheng DJ, Kerr IM, Waterfield MD (1985) Purification and characterization of vaccinia virus growth factor. Cell 42: 383–393PubMedGoogle Scholar
  118. Sugimoto M, Yasuda A, Miki K et al. (1985) Gene structures of low-neurovirulent vaccinia virus LC16m0, LC16m8, and their Lister original (LO) strains. Microbiol Immunol 29: 421–428PubMedGoogle Scholar
  119. Takahashi-Nishimaki F, Suzuki K, Morita M et al. (1987) Genetic analysis of vaccinia virus Lister strain and its attenuated mutant LC16m8: production of intermediate variants by homologous recombination. J Gen Virol 68: 2705–2710PubMedGoogle Scholar
  120. Tengelsen LA, Slabaugh MB, Bibler JK, Hruby DE (1988) Nucleotide sequence and molecular genetic analysis of the large subunit of ribonucleotide reductase encoded by vaccinia virus. Virology 164: 121–131PubMedGoogle Scholar
  121. Tomley F, Binns M, Campbell J, Boursnell M (1988) Sequence analysis of an 11.2 kilobase, near-terminal, BamHI fragment of fowlpox virus. J Gen Virol 69: 1025–1040PubMedGoogle Scholar
  122. Townsend A, Bastin J, Gould K et al. (1988) Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen. J Exp Med 168: 1211–1224PubMedGoogle Scholar
  123. Twardzik DR, Brown JP, Ranchalis JE, Todaro GJ, Moss B (1985) Vaccine virus-infected cells release a novel polypeptide functionally related to transforming and epidermal growth factors. Proc Natl Acad Sci USA 82: 5300–5304PubMedGoogle Scholar
  124. Upton C, Mcfadden G (1986a) DNA sequence homology between the terminal inverted repeats of Shope fibroma virus and an endogenous cellular plasmid species. Mol Cell Biol 6: 265–276PubMedGoogle Scholar
  125. Upton C, Mcfadden G (1986b) Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus. Virology 152: 308–321PubMedGoogle Scholar
  126. Upton C, Mcfadden G (1986c) Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus. J Virol 60: 920–927PubMedGoogle Scholar
  127. Upton C, Carrell RW, McFadden G (1986) A novel member of the serpin superfamily is encoded on a circular plasmid-like DNA species isolated from rabbit cells. FEBS Lett 207: 115–120PubMedGoogle Scholar
  128. Upton C, Macen JL, McFadden G (1987) Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha. J Virol 61: 1271–1275PubMedGoogle Scholar
  129. Van Tongeren HAE (1952) Spontaneous mutation of cowpox-virus by means of egg passage. Arch Gesamte Virusforsch 5: 35.Google Scholar
  130. Venkatesan S, Gershowitz A, and Moss B (1982) Complete nucleotide sequences of two adjacent early vaccinia virus genes located within the terminal repetition J Virol 44, 637–646PubMedGoogle Scholar
  131. Wittek R, Moss B (1980) Tandem repeats within the inverted terminal repetition of vaccinia virus DNA. Cell 21: 277–284PubMedGoogle Scholar
  132. Wittek R, Menna A, Schumperli D, Stoffel S, Muller HK, Wyler R (1977) HindIII and Sst I restriction sites mapped on rabbit poxvirus and vaccinia virus DNA. J Virol 23: 669–678PubMedGoogle Scholar
  133. Wittek R, Menna A, Muller HK, Schumperli D, Boseley PG, Wyler R (1978) Inverted terminal repeats in rabbit poxvirus and vaccinia virus DNA J Virol 28: 171–181PubMedGoogle Scholar
  134. Wittek R, Barbosa E, Cooper JA, Garon CF, Chan H, Moss B (1980) Inverted terminal repetition in vaccinia virus DNA encodes early mRNAs. Nature 285: 21–25PubMedGoogle Scholar
  135. Wittek R, Cooper JA, Moss B (1981) Transcriptional and translational mapping of a 6.6-kilobase-pair DNA fragment containing the junction of the terminal repetition and unique sequence at the left end of the vaccinia virus genome. J Virol 39: 722–732PubMedGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  • P. C. Turner
    • 1
  • R. W. Moyer
    • 1
  1. 1.Department of Immunology and Medical Microbiology, College of MedicineUniversity of FloridaGainesvilleUSA

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