Poxviruses pp 93-123 | Cite as

The Enzymology of Poxvirus DNA Replication

  • P. Traktman
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 163)


DNA replication is arguably the most fundamental of biological processes and serves as a pivotal element in the poxvirus life cycle. Replication generates progeny genomes and initiates the transition to late gene expression. Unraveling the mechanism of poxvirus replication and identifying the panoply of enzymatic activities which it requires has been a focus of much recent research. The intent of this chapter is to move beyond previous reviews (McFadden and Dales 1982; Holowczak 1983) and focus on viral proteins whose participation in DNA replication is presumed on the basis of genetic or biochemical data. Implicit in this discussion was the choice of a broad definition of DNA replication, one which centers on DNA synthesis but also encompasses regulation of the topology of genomic DNA and its assembly into a nucleoprotein complex.


Vaccinia Virus Thymidine Kinase Ribonucleotide Reductase Nonpermissive Temperature Late Gene Expression 
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© Springer-Verlag Berlin · Heidelberg 1990

Authors and Affiliations

  • P. Traktman
    • 1
  1. 1.Departments of Cell Biology and Anatomy and MicrobiologyCornell University Medical CollegeNew YorkUSA

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