Cytogenetics and Molecular Genetics of Cell Transformation in Vitro by Mutagens/Carcinogens

  • E. Gebhart
Part of the Advances in Mutagenesis Research book series (MUTAGENESIS, volume 2)


Since its detection by Berwald and Sachs (1965) and its further development by Di Paolo and his group (Di Paolo/Donovan 1967) mammalian cell transformation has been proposed as an in vitro model test system for the rapid detection of carcinogenic agents (Di Paolo et al. 1971; Heidelberger 1975; Styles 1980; Meyer 1983). A systematic comparison of the data from those studies with the results of classic mutagenicity tests revealed a rather high correlation between both fields (e.g., Ennever and Rosenkranz 1987). Therefore, transformation tests have also been included in protocols for mutagenicity testing.


Syrian Hamster Chemical Carcinogen Chromosome Change Human Diploid Fibroblast Familial Polyposis Coli 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • E. Gebhart
    • 1
  1. 1.Institute of Human GeneticsUniversity of Erlangen-NürnbergErlangenGermany

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